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Protein Page:
MLPH (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MLPH Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3). GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: cortical actin cytoskeleton; stress fiber; microtubule organizing center
Molecular Function: microtubule plus-end binding; metal ion binding; myosin V binding; actin binding; Rab GTPase binding
Biological Process: melanocyte differentiation; melanosome localization; protein targeting
Reference #:  Q9BV36 (UniProtKB)
Alt. Names/Synonyms: Exophilin-3; Melanophilin; MELPH; MGC2771; MGC59733; MLPH; SlaC2-a; SLAC2A; Slp homolog lacking C2 domains a; Synaptotagmin-like protein 2a
Gene Symbols: MLPH
Molecular weight: 65,949 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
Select Structure to View Below

MLPH

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 K136-ub FKRFGSAkVIRSLHG
0 2 S162 SEERSGDSDQTDEDG
0 2 T165 RSGDSDQTDEDGEPG
0 1 K185-ac QAQPFGSkKKRLLSV
0 1 H257 GASGCHSHPEEQPTS
0 1 S264 HPEEQPTSISPSRHG
0 1 S268 QPTSISPSRHGALAE
0 1 - gap
0 1 - under review  
0 2 T313 QYLADVDTSDEESIR
0 3 S314 YLADVDTSDEESIRA
0 7 S336-p SKRRGRAssESQIFE
0 11 S337-p KRRGRAssESQIFEL
0 4 Y454-p DPGDPVQyNRTtDEE
0 1 N455 PGDPVQyNRTtDEEL
0 2 T457 DPVQyNRTtDEELsE
0 4 T458-p PVQyNRTtDEELsEL
0 3 S463-p RTtDEELsELEDRVA
0 2 S481-p SEVQQAEsEVsDIES
0 2 S484-p QQAEsEVsDIESRIA
0 1 S510-p SGKPRRKsNLPIFLP
0 1 - gap
0 8 S552-p YLLRRKFsNsLKSQG
0 3 S554-p LRRKFsNsLKSQGkD
0 1 S557 KFsNsLKSQGkDDDS
0 1 K560-ub NsLKSQGkDDDSFDR
0 1 S564 SQGkDDDSFDRKSVY
0 1 S574-p RKSVYRGsLTQRNPN
  MLPH iso2  
K136 FKRFGSAKVIRSLHG
S162 SEERSGDSDQTDEDG
T165 RSGDSDQTDEDGEPG
K185 QAQPFGSKKKRLLSV
H257 GASGCHSHPEEQPTS
S264 HPEEQPTSISPSRHG
S268 QPTSISPSRHGALAE
- gap
- under review  
T313 QYLADVDTSDEESIR
S314 YLADVDTSDEESIRA
S336 SKRRGRASsESQGLG
S337-p KRRGRASsESQGLGA
Y426 DPGDPVQYNRTTDEE
N427 PGDPVQYNRTTDEEL
T429 DPVQYNRTTDEELSE
T430 PVQYNRTTDEELSEL
S435 RTTDEELSELEDRVA
S453 SEVQQAESEVSDIES
S456 QQAESEVSDIESRIA
S482 SGKPRRKSNLPIFLP
- gap
S524-p YLLRRKFsNSLKSQG
S526 LRRKFsNSLKSQGKD
S529 KFsNSLKSQGKDDDS
K532 NSLKSQGKDDDSFDR
S536 SQGKDDDSFDRKSVY
S546 RKSVYRGSLTQRNPN
  mouse

 
K136 FKRFGSAKVIRSLCG
S162-p LEEGNGDsEQtDEDG
T165-p GNGDsEQtDEDGDLD
K184 DQPLNSKKKKRLLSF
S256-p RALGCRPsPEVQPCs
S263-p sPEVQPCsPLPsGED
S267-p QPCsPLPsGEDAHAE
S277-p DAHAELDsPAASCKs
S284-p sPAASCKsAFGTTAM
T312-p QYLADVDtsDEDSIQ
S313-p YLADVDtsDEDSIQG
- gap
- gap
P442 SPGNPARPtKstDEE
T443-p PGNPARPtKstDEEL
S445-p NPARPtKstDEELsE
T446-p PARPtKstDEELsEM
S451-p KstDEELsEMEDRVA
S469-p SEVQQAEsEIsDIES
S472-p QQAEsEIsDIESRIA
S498-p SGKPRRKsGIPIFLP
T517-p KLDRIPKtPPADPDD
S544-p SLLRRKYsPSsQGVD
S546 LRRKYsPSsQGVDSG
S547-p RRKYsPSsQGVDSGs
- gap
S554-p sQGVDSGsFDRKSVY
S564 RKSVYRGSLTQRNPN
  rat

 
K136 FKRFGSAKVIRSLCG
S162-p LEEGNGDsEQtDEDG
T165-p GNGDsEQtDEDGELD
K184 DQSLNSKKKRLLSFR
S255 GASGCYPSPEEQPYS
S262 SPEEQPYSPLPSGED
S266 QPYSPLPSGEDAHTE
S276 DAHTELHSPATSCKS
S283 SPATSCKSTFGTTAM
T311-p QYLADVDtsDEDSIP
S312-p YLADVDtsDEDSIPG
- gap
- gap
P441 SPGNPAQPTKstDEE
T442 PGNPAQPTKstDEEL
S444-p NPAQPTKstDEELsE
T445-p PAQPTKstDEELsEM
S450-p KstDEELsEMEDRVA
S468 SEVQQAESEVSDIES
S471 QQAESEVSDIESRIA
S497 SGKPRRRSGIPIFLP
T516 KLDRIPKTPPADPEN
S542 CLMRRKYSPSSQGID
S544 MRRKYSPSSQGIDGG
S545 RRKYSPSSQGIDGGS
- gap
S552 SQGIDGGSFDRKSVY
S562 RKSVYRGSLTQRNPN
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