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Protein Page:
LAMB2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LAMB2 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMB2 are the cause of Pierson syndrome (PIERSS); also known as microcoria-congenital nephrotic syndrome. Pierson syndrome is characterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome. Defects in LAMB2 are the cause of nephrotic syndrome type 5 with or without ocular abnormalities (NPHS5). NPHS5 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. NPHS5 is characterized by very early onset of progressive renal failure. A subset of patients may develop mild ocular anomalies, such as myopia, nystagmus, and strabismus. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted
Cellular Component: extracellular matrix; laminin-3 complex; extracellular region; basement membrane; synapse; basal lamina
Molecular Function: integrin binding; structural molecule activity
Biological Process: axon guidance; extracellular matrix organization and biogenesis; Schwann cell development; visual perception; retina development in camera-type eye; axon extension involved in regeneration; cell adhesion; astrocyte development; neuromuscular junction development
Reference #:  P55268 (UniProtKB)
Alt. Names/Synonyms: LAMB2; Laminin B1s chain; laminin S; Laminin subunit beta-2; laminin, beta 2 (laminin S); Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; LAMS; S-LAM beta; S-laminin subunit beta
Gene Symbols: LAMB2
Molecular weight: 195,981 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
Select Structure to View Below

LAMB2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R170 ERSADFGRTWHVYRY
0 1 R176 GRTWHVYRYFSYDCG
0 1 Y232-p AIPIPDPySSRIQNL
0 1 T353 KCECHGHTHSCHFDM
0 1 S355 ECHGHTHSCHFDMAV
0 1 Y363 CHFDMAVYLASGNVS
0 1 S435 DPALGLVSGQCRCKE
0 1 T477-p CQCNARGtVPGSTPC
0 1 S614-p TLEFLVAsVPKAMDY
0 1 S1472-p RALAEGGsILsRVAE
0 1 S1475-p AEGGsILsRVAETRR
0 1 S1654-p AGAERALssAGERAR
0 1 S1655-p GAERALssAGERARQ
0 1 K1714-ub GDQYQTVkALAERKA
0 1 Y1759-p LQELEGTyEENERAL
0 1 K1769-ub NERALESkAAQLDGL
  mouse

 
R173 ERSADFGRTWHVYRY
R179 GRTWHVYRYFSYDCG
Y235 AIPIPDPYSSRIQNL
T356-p KCECNGHtHsCHFDM
S358-p ECNGHtHsCHFDMAV
Y366-p CHFDMAVyLASGNVS
S438-p DPVLGLVsGQCRCKE
T480 CQCNSRGTVPGSSPC
S617 EVEFLVTSLPRAMDY
G1473 RALVEGGGILSRVSE
S1476 VEGGGILSRVSETRR
N1655 AGAEKSLNSAGERAR
S1656 GAEKSLNSAGERARQ
R1715 GDQYQTVRALAERKA
Y1760 LQELEGTYEENERAL
K1770 NERALEGKAAQLDGL
  rat

 
R173-m1 ERSADFGrTWRVYrY
R179-m1 GrTWRVYrYFSYDCG
Y235 AIPIPDPYSSRIQNL
S356 KCECNGHSHSCHFDM
S358 ECNGHSHSCHFDMAV
Y366 CHFDMAVYLASGNVS
S438 DPVLGLVSGQCRCKE
T480 CQCNSRGTVPGGTPC
S617 EVEFLVTSLPRAMDY
G1475 RALVEGGGILSRVSE
S1478 VEGGGILSRVSETRR
N1657 AGTEQSLNSASERAR
S1658 GTEQSLNSASERARQ
R1717 GDQYQTVRALAERKA
Y1762 LQELEGTYEENEREL
K1772 NERELEVKAAQLDGL
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