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Protein Page:
SETBP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SETBP1 Defects in SETBP1 are the cause of Schinzel-Giedion midface retraction syndrome (SGMFS). It is a disorder characterized by severe mental retardation, distinctive facial features, and multiple congenital malformations including skeletal abnormalities, genitourinary and renal malformations, cardiac defects, as well as a higher-than-normal prevalence of tumors, notably neuroepithelial neoplasia. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: nucleus
Molecular Function: DNA binding
Reference #:  Q9Y6X0 (UniProtKB)
Alt. Names/Synonyms: DKFZp666J1210; KIAA0437; SEB; SET binding protein 1; SET-binding protein; SETBP; SETBP1
Gene Symbols: SETBP1
Molecular weight: 175,008 Da
Basal Isoelectric point: 9.76  Predict pI for various phosphorylation states
Select Structure to View Below

SETBP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S8-p MESRETLsSsRQRGG
0 1 S10-p SRETLsSsRQRGGES
0 1 K140-ac IKQSGDQkVSRAGkN
0 1 K146-ac QkVSRAGkNSKATKE
0 1 S172-p TASDLAAsDLKGFQP
0 1 T273-p KKGSAGNtWSQLSNN
0 1 N357 PDLDWVKNAQKAFDN
0 2 S439-p MPEKALAsGITMSSE
0 1 T550 LREAVMATSDKLMLE
0 1 S611-p GTSTSPVsPISREFP
0 1 S687-p QILSCSSsVALKAKA
0 1 T720-p INVSKRGtIYIGkKR
0 1 K725-m1 RGtIYIGkKRGRKPR
0 1 K1024-m2 KKRGRPAkTNDTMTK
0 1 S1039-p VPFLQGFsyPIPSGS
0 1 Y1040-p PFLQGFsyPIPSGSY
0 1 Y1263-p VDSCTKRysGsGGDG
0 1 S1264-p DSCTKRysGsGGDGG
0 1 S1266-p CTKRysGsGGDGGst
0 1 S1272-p GsGGDGGstRSENLD
0 1 T1273-p sGGDGGstRSENLDV
0 1 S1298-p WDSDVSGsKRRSYEG
0 1 S1379-p IPPAPVLsLLAASAA
0 1 S1394-p TSDAVGSsLKKRFKR
0 1 T1445-p RLQRQSKtGNNFVkk
0 1 K1451-ac KtGNNFVkkRRGRPR
0 1 K1452-ac tGNNFVkkRRGRPRK
0 3 K1484-ac KCIDLPSkRGQKPSL
  mouse

 
S8 MEPREMLSSCRQRGS
C10 PREMLSSCRQRGSES
K133 IKQSGDQKVSRTGKN
K139 QKVSRTGKNSKATKE
S165 TAGDPTASDLKAFQT
A266 KKGSTGGAWSQLSSS
S350-p SDLDWVKsAQKAFET
S432 VPEKALASGISMSSE
T541-p LREAVLAtAEKLMVE
S602 GTSTSPVSPISREFP
S678 QILSCSSSVALKAKA
T711 INVSKRGTIYIGKKR
K716 RGTIYIGKKRGRKPR
K1015 KKRGRPAKTNDTMTK
S1030 VPFLQGFSYPIPSGS
Y1031 PFLQGFSYPIPSGSY
Y1254 VESCAKRYSGSGGDS
S1255 ESCAKRYSGSGGDST
S1257 CAKRYSGSGGDSTRS
S1261 YSGSGGDSTRSEGLD
T1262 SGSGGDSTRSEGLDV
S1287 WDSDMGGSKRRSFEG
S1368 IPSAPVLSLLAASAA
S1383 TSDAASSSLKKRFKR
T1434 RLQRQSKTGNNFVKK
K1440 KTGNNFVKKRRGRPR
K1441 TGNNFVKKRRGRPRK
K1473-ac KCIDLPSkRGQKPSL
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