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Protein Page:
SETBP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SETBP1 Defects in SETBP1 are the cause of Schinzel-Giedion midface retraction syndrome (SGMFS). It is a disorder characterized by severe mental retardation, distinctive facial features, and multiple congenital malformations including skeletal abnormalities, genitourinary and renal malformations, cardiac defects, as well as a higher-than-normal prevalence of tumors, notably neuroepithelial neoplasia. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: nucleus
Molecular Function: DNA binding
Reference #:  Q9Y6X0 (UniProtKB)
Alt. Names/Synonyms: DKFZp666J1210; KIAA0437; SEB; SET binding protein 1; SET-binding protein; SETBP; SETBP1
Gene Symbols: SETBP1
Molecular weight: 175,008 Da
Basal Isoelectric point: 9.76  Predict pI for various phosphorylation states
Select Structure to View Below

SETBP1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S439-p MPEKALAsGITMSSE
0 1 S687-p QILSCSSsVALKAKA
0 3 K1484-a KCIDLPSkRGQKPSL
  mouse

 
S432 VPEKALASGISMSSE
S678 QILSCSSSVALKAKA
K1473-a KCIDLPSkRGQKPSL
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