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Protein Page:
THPO (human)

Overview
THPO Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Secreted; Cytokine; Secreted, signal peptide
Cellular Component: extracellular space
Molecular Function: growth factor activity; hormone activity; cytokine activity
Biological Process: positive regulation of protein kinase B signaling cascade; cell proliferation; platelet activation; multicellular organismal development; myeloid cell differentiation; positive regulation of megakaryocyte differentiation; positive regulation of protein amino acid phosphorylation; blood coagulation
Reference #:  P40225 (UniProtKB)
Alt. Names/Synonyms: C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; megakaryocyte stimulating factor; MGC163194; MGDF; MKCSF; ML; MPL ligand; MPLLG; Myeloproliferative leukemia virus oncogene ligand; THPO; Thrombopoietin; thrombopoietin nirs variant 1; TPO
Gene Symbols: THPO
Molecular weight: 37,823 Da
Basal Isoelectric point: 9.54  Predict pI for various phosphorylation states
Select Structure to View Below

THPO

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S34-p ACDLRVLsKLLRDSH
0 1 H41 sKLLRDSHVLHSRLS
0 1 T58-p PEVHPLPtPVLLPAV
0 1 S68-p LLPAVDFsLGEWKTQ
0 1 T79-p WKTQMEEtKAQDILG
0 1 T205-p RTSGLLEtNFTASAR
0 1 S216-p ASARTTGsGLLKWQQ
  mouse

 
N34 ACDPRLLNKLLRDSH
H41 NKLLRDSHLLHSRLS
I58 PDVDPLSIPVLLPAV
S68 LLPAVDFSLGEWKTQ
S79 WKTQTEQSKAQDILG
T205 RTSGLLETNFSVTAR
P216 VTARTAGPGLLSRLQ
  rat

 
N34 ACDPRLLNKLLRDSy
Y41-p NKLLRDSyLLHSRLS
I58 PDVNPLSIPVLLPAV
S68 LLPAVDFSLGEWKTQ
S79 WKTQTEQSKAQDILG
T205 RTSGLLETNFSVVAR
P216 VVARTAGPGLLNRLQ
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