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Protein Page:
THPO (human)

THPO Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide; Cell cycle regulation
Cellular Component: extracellular space
Molecular Function: growth factor activity; hormone activity; cytokine activity
Biological Process: platelet activation; positive regulation of protein kinase B signaling cascade; cell proliferation; multicellular organismal development; myeloid cell differentiation; positive regulation of megakaryocyte differentiation; positive regulation of protein amino acid phosphorylation; blood coagulation
Reference #:  P40225 (UniProtKB)
Alt. Names/Synonyms: C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; megakaryocyte stimulating factor; MGC163194; MGDF; MKCSF; ML; MPL ligand; MPLLG; Myeloproliferative leukemia virus oncogene ligand; THPO; Thrombopoietin; thrombopoietin nirs variant 1; TPO
Gene Symbols: THPO
Molecular weight: 37,823 Da
Basal Isoelectric point: 9.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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