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THPO (human)

Overview THPO Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Cell cycle regulation; Cytokine; Secreted Cellular Component: extracellular space Molecular Function: growth factor activity; hormone activity; cytokine activity Biological Process: platelet activation; cell proliferation; multicellular organismal development; positive regulation of cell proliferation; myeloid cell differentiation; response to lipopolysaccharide; blood coagulation Reference #:  P40225 (UniProtKB) Alt. Names/Synonyms: C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; megakaryocyte stimulating factor; MGC163194; MGDF; MKCSF; ML; MPL ligand; MPLLG; Myeloproliferative leukemia virus oncogene ligand; THPO; Thrombopoietin; thrombopoietin nirs variant 1; TPO Gene Symbols: THPO Molecular weight: 37,823 Da Basal Isoelectric point: 9.54  Predict pI for various phosphorylation states

Select Structure to View Below THPO 1V7M - V/X=22-184 (human) 1V7N - V/X/Y/Z=22-184 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1V7M 1V7N  |  Phospho3D  |  DISEASE 187950 600044  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T58-p	PEVHPLPtPVLLPAV
0	1		H41	SKLLRDSHVLHSRLS
0	1		S68-p	LLPAVDFsLGEWKTQ
0	1		T79-p	WKTQMEEtKAQDILG
0	1		T205-p	RTSGLLEtNFTASAR
0	1		S216-p	ASARTTGsGLLKWQQ

	mouse
I58	PDVDPLSIPVLLPAV
H41	NKLLRDSHLLHSRLS
S68	LLPAVDFSLGEWKTQ
S79	WKTQTEQSKAQDILG
T205	RTSGLLETNFSVTAR
P216	VTARTAGPGLLSRLQ

	rat
I58	PDVNPLSIPVLLPAV
Y41-p	NKLLRDSyLLHSRLS
S68	LLPAVDFSLGEWKTQ
S79	WKTQTEQSKAQDILG
T205	RTSGLLETNFSVVAR
P216	VVARTAGPGLLNRLQ

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