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Protein Page:
eIF5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
eIF5 eukaryotic translation initiation factor 5. Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex. Note: This description may include information from UniProtKB.
Protein type: Translation initiation; Translation
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: GTPase activity; GTP binding; translation factor activity, nucleic acid binding; translation initiation factor activity
Biological Process: cellular protein metabolic process; translation; GTP catabolic process; translational initiation; gene expression; regulation of translational initiation
Reference #:  P55010 (UniProtKB)
Alt. Names/Synonyms: eIF-5; EIF-5A; EIF5; Eukaryotic translation initiation factor 5; IF5
Gene Symbols: EIF5
Molecular weight: 49,223 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

eIF5

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S389‑p, S390‑p
translation, altered: S389‑p, S390‑p
molecular association, regulation: S389‑p, S390‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S8-p MSVNVNRsVsDQFYR
0 11 S10-p VNVNRsVsDQFYRyK
0 1 Y16-p VsDQFYRyKMPRLIA
0 2 K28-ac LIAKVEGkGNGIkTV
0 3 K33-ac EGkGNGIkTVIVNMV
0 17 K55-ac RPPTYPTkYFGCELG
0 3 K55-ub RPPTYPTkYFGCELG
0 1 K143 KLCTFILKNPPENsD
0 1 S149-p LKNPPENsDsGTGKK
0 1 S151-p NPPENsDsGTGKKEK
1 0 S174 DKENGSVSssETPPP
0 1 S175-p KENGSVSssETPPPP
0 1 S176-p ENGSVSssETPPPPP
1 0 T207-p DDDWGEDttEEAQRR
1 0 T208-p DDWGEDttEEAQRRR
0 3 T227-p SDHAKVLtLsDDLER
0 12 S229-p HAKVLtLsDDLERTI
0 2 K288-ub TEVLFNEkIREQIKK
0 2 Y362-p SEKASKKyVSKELAK
3 74 S389-p LKEAEEEssGGEEED
3 74 S390-p KEAEEEssGGEEEDE
0 1 E397 sGGEEEDEDENIEVV
0 36 Y405-p DENIEVVysKAAsVP
0 2 S406-p ENIEVVysKAAsVPK
0 4 S410-p VVysKAAsVPKVETV
0 8 S419-p PKVETVKsDNKDDDI
  mouse

 
S8 MSVNVNRSVsDQFYR
S10-p VNVNRSVsDQFYRYK
Y16 VsDQFYRYKMPRLIA
K28-ac LIAKVEGkGNGIkTV
K33-ac EGkGNGIkTVIVNMV
K55 RPPTYPTKYFGCELG
K55-ub RPPTYPTkYFGCELG
K143-ub KLCTFILkNPPENSD
S149 LkNPPENSDIGTGKK
I151 NPPENSDIGTGKKEK
S174 DKENGSVSTSETPPP
T175 KENGSVSTSETPPPP
S176 ENGSVSTSETPPPPP
T205 DDDWGEDTTEEAQRR
T206 DDWGEDTTEEAQRRR
T225 SDHAKGLTLsDDLER
S227-p HAKGLTLsDDLERTV
K286 TEVLFDEKIREQIKK
Y360-p SEKASKKyVSKELAK
S387-p LKEAEEEssGGEEED
S388-p KEAEEEssGGEEEDe
E395-p sGGEEEDeDENIEVV
Y403-p DENIEVVySKTAsVP
S404 ENIEVVySKTAsVPK
S408-p VVySKTAsVPKVETV
S417-p PKVETVKsDNKDDDI
  rat

 
S8 MSVNVNRSVSDQFYR
S10 VNVNRSVSDQFYRYK
Y16 VSDQFYRYKMPRLIA
K28 LIAKVEGKGNGIKTV
K33 EGKGNGIKTVIVNMV
K55 RPPTYPTKYFGCELG
K55 RPPTYPTKYFGCELG
K143 KLCTFILKNPPENSD
S149 LKNPPENSDIGTGKK
I151 NPPENSDIGTGKKEK
S174-p DKENGSVsTSETPPP
T175 KENGSVsTSETPPPP
S176 ENGSVsTSETPPPPP
T205 DDDWGEDTTEEAQRR
T206 DDWGEDTTEEAQRRR
T225 SDHAKGLTLsDDLER
S227-p HAKGLTLsDDLERTV
K286 TEVLFDEKIREQIKK
Y360 SEKASKKYVSKELAK
S387-p LKEAEEEssGGEEED
S388-p KEAEEEssGGEEEDE
E395 sGGEEEDEDENIEVV
Y403 DENIEVVYSKTASVP
S404 ENIEVVYSKTASVPK
S408 VVYSKTASVPKVETV
S417-p PKVETVKsDNKDDDI
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