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eIF5 (human)

Overview eIF5 eukaryotic translation initiation factor 5. Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex. Note: This description may include information from UniProtKB. Protein type: Translation; Translation initiation Cellular Component: cytoplasm; cytosol Molecular Function: GTPase activity; GTP binding; translation factor activity, nucleic acid binding; translation initiation factor activity Biological Process: cellular protein metabolic process; translation; RNA metabolic process; GTP catabolic process; translational initiation; gene expression; regulation of translational initiation Reference #:  P55010 (UniProtKB) Alt. Names/Synonyms: eIF-5; EIF-5A; EIF5; Eukaryotic translation initiation factor 5; IF5 Gene Symbols: EIF5 Molecular weight: 49,223 Da Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states CST Pathways:  Translation: eIF2  |  Translational Control Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below eIF5 2E9H - A=1-150 (human) 2G2K - A=1-170 (human) 2IU1 - A=232-431 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2E9H 2G2K 2IU1  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: S389‑p, S390‑p translation, altered: S389‑p, S390‑p molecular association, regulation: S389‑p, S390‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	7		S10-p	VNVNRSVsDQFYRyK
0	1		Y16-p	VsDQFYRyKMPRLIA
0	2		K28-a	LIAKVEGkGNGIkTV
0	3		K33-a	EGkGNGIkTVIVNMV
0	17		K55-a	RPPTYPTkYFGCELG
0	3		K55-u	RPPTYPTkYFGCELG
0	1		K143	KLCTFILKNPPENsD
0	1		S149-p	LKNPPENsDSGTGKK
1	0		S174	DKENGSVSssETPPP
0	1		S175-p	KENGSVSssETPPPP
0	1		S176-p	ENGSVSssETPPPPP
1	0		T207-p	DDDWGEDttEEAQRR
1	0		T208-p	DDWGEDttEEAQRRR
0	2		T227-p	SDHAKVLtLsDDLER
0	10		S229-p	HAKVLtLsDDLERTI
0	2		K288-u	TEVLFNEkIREQIKK
0	2		Y362-p	SEKASKKyVSKELAK
3	65		S389-p	LKEAEEEssGGEEED
3	65		S390-p	KEAEEEssGGEEEDE
0	1		E397	sGGEEEDEDENIEVV
0	38		Y405-p	DENIEVVysKAAsVP
0	2		S406-p	ENIEVVysKAAsVPK
0	2		S410-p	VVysKAAsVPKVETV
0	6		S419-p	PKVETVKsDNKDDDI

	mouse
S10-p	VNVNRSVsDQFYRYK
Y16	VsDQFYRYKMPRLIA
K28-a	LIAKVEGkGNGIkTV
K33-a	EGkGNGIkTVIVNMV
K55	RPPTYPTKYFGCELG
K55-u	RPPTYPTkYFGCELG
K143-u	KLCTFILkNPPENSD
S149	LkNPPENSDIGTGKK
S174	DKENGSVSTSETPPP
T175	KENGSVSTSETPPPP
S176	ENGSVSTSETPPPPP
T205	DDDWGEDTTEEAQRR
T206	DDWGEDTTEEAQRRR
T225	SDHAKGLTLsDDLER
S227-p	HAKGLTLsDDLERTV
K286	TEVLFDEKIREQIKK
Y360-p	SEKASKKyVSKELAK
S387-p	LKEAEEEssGGEEED
S388-p	KEAEEEssGGEEEDe
E395-p	sGGEEEDeDENIEVV
Y403-p	DENIEVVySKTAsVP
S404	ENIEVVySKTAsVPK
S408-p	VVySKTAsVPKVETV
S417-p	PKVETVKsDNKDDDI

	rat
S10	VNVNRSVSDQFYRYK
Y16	VSDQFYRYKMPRLIA
K28	LIAKVEGKGNGIKTV
K33	EGKGNGIKTVIVNMV
K55	RPPTYPTKYFGCELG
K55	RPPTYPTKYFGCELG
K143	KLCTFILKNPPENSD
S149	LKNPPENSDIGTGKK
S174-p	DKENGSVsTSETPPP
T175	KENGSVsTSETPPPP
S176	ENGSVsTSETPPPPP
T205	DDDWGEDTTEEAQRR
T206	DDWGEDTTEEAQRRR
T225	SDHAKGLTLsDDLER
S227-p	HAKGLTLsDDLERTV
K286	TEVLFDEKIREQIKK
Y360	SEKASKKYVSKELAK
S387-p	LKEAEEEssGGEEED
S388-p	KEAEEEssGGEEEDE
E395	sGGEEEDEDENIEVV
Y403	DENIEVVYSKTASVP
S404	ENIEVVYSKTASVPK
S408	VVYSKTASVPKVETV
S417-p	PKVETVKsDNKDDDI

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