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Protein Page:
MICAL1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MICAL1 Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Belongs to the Mical family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 1.14.13.-; Adaptor/scaffold
Cellular Component: cytoplasm; intermediate filament
Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; protein binding; zinc ion binding; actin binding; SH3 domain binding; Rab GTPase binding
Biological Process: actin filament depolymerization; negative regulation of protein amino acid phosphorylation; cytoskeleton organization and biogenesis; negative regulation of caspase activity; signal transduction; sulfur oxidation; negative regulation of apoptosis
Reference #:  Q8TDZ2 (UniProtKB)
Alt. Names/Synonyms: CasL interacting molecule; DKFZp434B1517; FLJ11937; FLJ21739; MICA1; MICAL; MICAL-1; MICAL1; microtubule associated monoxygenase, calponin and LIM domain containing 1; Molecule interacting with CasL protein 1; NEDD9 interacting protein with calponin homology and LIM domains; NEDD9-interacting protein with calponin homology and LIM domains; NICAL
Gene Symbols: MICAL1
Molecular weight: 117,875 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below

MICAL1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T241-p GKLAIGItANFVNGR
0 2 T475-p NLNLRAVtPNQVRDL
0 91 Y483-p PNQVRDLyDVLAkEP
0 5 K488-u DLyDVLAkEPVQRNN
0 5 S617-p AFKSMAHsPGPVsQA
0 1 S622-p AHsPGPVsQAsPGTS
0 5 S625-p PGPVsQAsPGTSSAV
0 1 K637-u SAVLFLSkLQRTLQR
0 1 S767-p GSDRGPEsPELPTPS
0 14 G793 TASQEGAGPVPDPSQ
0 6 D797 EGAGPVPDPSQPTRR
0 2 S799 AGPVPDPSQPTRRQI
0 2 S809-p TRRQIRLssPERQRL
0 24 S810-p RRQIRLssPERQRLs
0 28 S817-p sPERQRLssLNLtPD
0 48 S818-p PERQRLssLNLtPDP
0 4 T822-p RLssLNLtPDPEMEP
0 5 S838-p PKPPRSCsALARHAL
0 3 S848-p ARHALESsFVGWGLP
0 33 S858-p GWGLPVQsPQALVAM
0 2 S872-p MEKEEKEsPFssEEE
0 3 S875-p EEKEsPFssEEEEED
0 3 S876-p EKEsPFssEEEEEDV
0 66 Y906-p TSGTMNNyPtWRRtL
0 9 T908-p GTMNNyPtWRRtLLR
0 2 T912-p NyPtWRRtLLRRAKE
0 7 S960-p ELALRRQsSSPEQQK
0 1 K1036-u AEDQVLRkLVDLVNQ
0 3 S1057-p FQEERRLsELALGTG
  mouse

 
T241 GKLAIGITANFVNGR
T475 NLNLRAVTPNQVQDL
Y483 PNQVQDLYDMMDKEH
K488 DLYDMMDKEHAQRKS
S616 AFKNTSHSSGLVSQP
S621 SHSSGLVSQPSGTPS
S624 SGLVSQPSGTPSAIL
K635 SAILFLGKLQRSLQR
S753 DNNGSLESQELPTPG
S777-p SPPVTRVsPVPsPsQ
S781-p TRVsPVPsPsQPARR
S783-p VsPVPsPsQPARRLI
S793-p ARRLIRLssLERLRL
S794-p RRLIRLssLERLRLS
S801 sLERLRLSSLNIIPD
S802 LERLRLSSLNIIPDS
I806 RLSSLNIIPDSGAEP
S822 PKPPRSCSDLARESL
S832 ARESLKSSFVGWGVP
A842 GWGVPVQAPQVPEAI
- gap
- gap
- gap
Y893 NPGAMTKYPTWRRTL
T895 GAMTKYPTWRRTLMR
T899 KYPTWRRTLMRRAKE
S947 ELALRKESSSPEQQK
K1023 SENQVLRKLLEVVNQ
R1044 FQEERRLREMPA___
  rat

 
T241 GKLAIGITANFVNGR
T475 NLNLRAVTPNQVQDL
Y483 PNQVQDLYDIMDKEH
K488 DLYDIMDKEHARKKS
S616 AFKNTPHSSGLVSQP
S621 PHSSGLVSQPHGTPS
H624 SGLVSQPHGTPSAIL
K635 SAILFLGKLQRSLQR
N751 DNNGSPENQELPTPG
S777 VPPVTEASPVPSPSQ
S781 TEASPVPSPSQPARR
S783 ASPVPSPSQPARRLI
S793 ARRLIRLSSVERLRL
S794 RRLIRLSSVERLRLS
S801 SVERLRLSSLNIIPD
S802 VERLRLSSLNIIPDS
I806 RLSSLNIIPDSGVEP
L822 PKPPRSCLDLAQESL
S832 AQESLKSSFMGWGVL
A841 MGWGVLRAPQVPEAI
- gap
- gap
- gap
Y893 NSGDMTKYPTWRRTL
T895 GDMTKYPTWRRTLMR
T899 KYPTWRRTLMRRAKE
S947 EVALRKESSSPEKQK
K1022 SEDRVLRKLLDVVNQ
R1043 FQEERRLREMPV___
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