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MetAP2 (human)

Overview MetAP2 Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Interacts strongly with the eIF-2 gamma-subunit EIF2S3. Binds EIF2S1 at low magnesium concentrations. Belongs to the peptidase M24A family. Note: This description may include information from UniProtKB. Protein type: Protease; EC 3.4.11.18 Cellular Component: cytoplasm Molecular Function: metalloexopeptidase activity; metal ion binding; aminopeptidase activity Biological Process: peptidyl-methionine modification; protein processing; proteolysis; N-terminal protein amino acid modification Reference #:  P50579 (UniProtKB) Alt. Names/Synonyms: AMPM2; eIF-2-associated p67 homolog; Initiation factor 2-associated 67 kDa glycoprotein; MAP 2; MAP2; MetAP 2; METAP2; Methionine aminopeptidase 2; methionyl aminopeptidase 2; MNPEP; p67; P67EIF2; Peptidase M 2 Gene Symbols: METAP2 Molecular weight: 52,892 Da Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MetAP2 1B59 - A=109-478 (human) 1B6A - A=1-478 (human) 1BN5 - A=1-478 (human) 1BOA - A=1-478 (human) 1KQ0 - A=1-478 (human) 1KQ9 - A=1-478 (human) 1QZY - A=1-478 (human) 1R58 - A=110-478 (human) 1R5G - A=110-478 (human) 1R5H - A=110-478 (human) 1YW7 - A=110-478 (human) 1YW8 - A=110-478 (human) 1YW9 - A=110-478 (human) 2ADU - A=110-478 (human) 2EA2 - A=110-478 (human) 2EA4 - A=110-478 (human) 2GA2 - A=110-478 (human) 2OAZ - A=110-478 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		A9	AGVEEVAASGSHLNG
0	2		S45-p	KRRKKKKsKGPSAAG
0	1		K58-u	AGEQEPDkEsGAsVD
0	3		S60-p	EQEPDkEsGAsVDEV
0	3		S63-p	PDkEsGAsVDEVARQ
0	2		S74-p	VARQLERsALEDkER
0	1		K79-u	ERsALEDkERDEDDE
0	1		T96-p	DGDGDGAtGkkKKKK
0	8		K98-u	DGDGAtGkkKKKKKK
0	3		K99-u	GDGAtGkkKKKKKKK
0	1		-	gap
0	1		Y137-p	PKGQECEyPPTQDGR
0	1		T145-p	PPTQDGRtAAWRTTS
0	1		Y182-p	AHRQVRKyVMSWIKP
0	1		K278-u	PKYDTLLkAVkDATN
0	2		K281-u	DTLLkAVkDATNTGI
0	2		K289-u	DATNTGIkCAGIDVR
0	1		K348	GKTVPIVKGGEATRM
0	1		T369-p	AIETFGStGKGVVHD
0	1		K427-a	LDRLGESkYLMALKN
0	3		K427-u	LDRLGESkYLMALKN

	mouse ► Hide Isoforms
S9-p	AGVEQAAsFGGHLNG
G45	KRRKKKKGKGAVSAV
K58	AVQQELDKESGALVD
S60	QQELDKESGALVDEV
L63	LDKESGALVDEVAKQ
Q74	VAKQLESQALEEKER
K79	ESQALEEKERDDDDE
T96	DGDADGATGKkKKKK
K98	DADGATGKkKKKKKK
K99-u	ADGATGKkKKKKKKK
-	gap
Y137	PKGQECEYPPTQDGR
T145	PPTQDGRTAAWRTTS
Y182	AHRQVRKYVMSWIKP
T278	PKYDILLTAVkDATN
K281-u	DILLTAVkDATNTGI
K289-u	DATNTGIkCAGIDVR
K348-u	GKTVPIVkGGEATRM
T369	AIETFGSTGKGVVHD
K427	LDRLGESKYLMALKN
K427-u	LDRLGESkYLMALKN

	MetAP2 iso2
S9	AGVEQAASFGGHLNG
G45	KRRKKKKGKGAVSAV
K58	AVQQELDKESGALVD
S60	QQELDKESGALVDEV
L63	LDKESGALVDEVAKQ
Q74	VAKQLESQALEEKER
K79	ESQALEEKERDDDDE
T96	DGDADGATGKKKKKK
K98	DADGATGKKKKKKKK
K99	ADGATGKKKKKKKKK
S110-p	KKKKRGHsITEYLYL
Y147	PKGQECEYPPTQDGR
T155	PPTQDGRTAAWRTTS
Y192	AHRQVRKYVMSWIKP
T288	PKYDILLTAVKDATN
K291	DILLTAVKDATNTGI
K299	DATNTGIKCAGIDVR
K358	GKTVPIVKGGEATRM
T379	AIETFGSTGKGVVHD
K437	LDRLGESKYLMALKN
K437	LDRLGESKYLMALKN

	rat
S9	AGVEEASSFGGHLNR
G45	KRRKKKKGKGAVSAG
K58	AGQQELDKESGTSVD
S60	QQELDKESGTSVDEV
S63	LDKESGTSVDEVAKQ
Q74	VAKQLERQALEEKEK
K79	ERQALEEKEKDDDDE
A96	DGDGDGAAGKKKKKK
K98	DGDGAAGKKKKKKKK
K99	GDGAAGKKKKKKKKK
-	gap
Y137	PKGQECEYPPTQDGR
T145	PPTQDGRTAAWRTTS
Y182	AHRQVRKYVMSWIKP
K278	PKYDILLKAVKDATN
K281	DILLKAVKDATNTGI
K289	DATNTGIKCAGIDVR
K348	GKTVPIVKGGEATRM
T369	AIETFGSTGKGVVHD
K427	LDRLGESKYLMALKN
K427	LDRLGESKYLMALKN

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