The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis
Cellular Component: cell surface; membrane; integral to plasma membrane; plasma membrane; phagocytic vesicle; integrin complex; external side of plasma membrane
Molecular Function: viral receptor activity; voltage-gated calcium channel activity; protein binding; opsonin binding; insulin-like growth factor I binding; protein kinase C binding; transforming growth factor beta binding; metal ion binding
Biological Process: negative regulation of lipid transport; integrin-mediated signaling pathway; axon guidance; entry of virus into host cell; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; negative regulation of lipoprotein metabolic process; cell-matrix adhesion; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; entry of symbiont into host cell by promotion of host phagocytosis; regulation of phagocytosis; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of low-density lipoprotein receptor biosynthetic process; virus-host interaction; positive regulation of osteoblast proliferation; positive regulation of cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; angiogenesis; blood coagulation; cell adhesion; leukocyte migration; apoptotic cell clearance; positive regulation of cell migration; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.