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Protein Page:
ITGAV (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITGAV The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 2q31-q32
Cellular Component: filopodium membrane; focal adhesion; cell surface; membrane; microvillus membrane; integral to plasma membrane; plasma membrane; phagocytic vesicle; integrin complex; external side of plasma membrane
Molecular Function: viral receptor activity; voltage-gated calcium channel activity; protein binding; opsonin binding; insulin-like growth factor I binding; protein kinase C binding; protease binding; extracellular matrix binding; transforming growth factor beta binding; metal ion binding; fibronectin binding
Biological Process: negative regulation of lipid transport; axon guidance; extracellular matrix organization and biogenesis; entry of virus into host cell; positive regulation of cell adhesion; cell-matrix adhesion; negative chemotaxis; entry of symbiont into host cell by promotion of host phagocytosis; regulation of phagocytosis; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; angiogenesis; cell adhesion; cell growth; integrin-mediated signaling pathway; cell migration; negative regulation of lipoprotein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell-substrate adhesion; heterotypic cell-cell adhesion; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of osteoblast proliferation; blood coagulation; vascular endothelial growth factor receptor signaling pathway; leukocyte migration; apoptotic cell clearance; positive regulation of cell migration
Reference #:  P06756 (UniProtKB)
Alt. Names/Synonyms: antigen identified by monoclonal antibody L230; CD51; DKFZp686A08142; Integrin alpha-V; Integrin alpha-V heavy chain; Integrin alpha-V light chain; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); ITAV; ITGAV; MSK8; Vitronectin receptor subunit alpha; VNRA
Gene Symbols: ITGAV
Molecular weight: 116,038 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Select Structure to View Below

ITGAV

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S21-p RGLPLLLsGLLLPLC
0 1 S59 AVDFFVPSASSRMFL
0 1 A60 VDFFVPSASSRMFLL
0 2 K233-ub DPNVYSIkYNNQLAT
0 1 T279-p GVPRAARtLGMVyIY
0 1 Y284-p ARtLGMVyIYDGKNM
0 2 K360-ub SGDFQTTkLNGFEVF
0 1 K399-ub APYGGEDkKGIVyIF
0 1 Y404-p EDkKGIVyIFNGRST
0 1 K446-ub KGATDIDkNGYPDLI
0 1 K581-ub DESEFRDkLTPItIF
0 1 T586-p RDkLTPItIFMEyRL
0 1 Y591-p PItIFMEyRLDYRTA
0 1 K645-ub VSVDSDQkKIYIGDD
0 1 S749-p KFDLQIQsSNLFDKV
0 1 S866-p NPLRIKIsSLQTTEk
0 1 K873-ub sSLQTTEkNDTVAGQ
0 6 S1046-p HENGEGNsEt_____
0 2 T1048-p NGEGNsEt_______
  mouse

 
P21 GGLLLLLPGLLLPLA
S59-p AVDFFEPstSSRMFL
T60-p VDFFEPstSSRMFLL
K233 DPNVYSIKYNNQLAT
T279 GVPRAARTLGMVYIY
Y284 ARTLGMVYIYDGKNM
K360 VGDFQTTKLNGFEVF
K399 APYGGEDKKGLVYIF
Y404 EDKKGLVYIFNGRST
R446 KGATDVDRNGYPDLV
K581 DESEFRDKLTPITIF
T586 RDKLTPITIFMEYRL
Y591 PITIFMEYRLDQRTA
K645 VSVNSDQKKIYIGDD
S749 KFDLKIQSSNSFDNV
- gap
K868 LRIKTPEKNDTAAAG
S1042-p HENGEGNsEt_____
T1044-p NGEGNsEt_______
  rat

 
L21 GGLLLLLLGLLLPFA
S59 AVDFFVPSTSSRMFL
T60 VDFFVPSTSSRMFLL
K233 DPNVYSIKYNNQLAT
T279 GVPRAARTLGMVYIY
Y284 ARTLGMVYIYDGKNM
K360 SGDFQTTKLNGFEVF
K399 APYGGEDKKGLVYIF
Y404 EDKKGLVYIFNGRST
R446 KGATDVDRNGYPDLV
Y580 PISKGRVYSCQMDVR
- under review  
Y590 QMDVRRGYIVKKPIS
K644 VSVDSDQKKIYIGDD
S748 KFDLKIQSSNSFDNV
- gap
K867 LRIKTPEKNDTAAEQ
S1040-p HENGEGNsET_____
T1042 NGEGNsET_______
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