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ITGAV
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion |
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Cellular Component: cell surface; membrane; integral to plasma membrane; plasma membrane; phagocytic vesicle; integrin complex; external side of plasma membrane
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Molecular Function: voltage-gated calcium channel activity; protein binding; opsonin binding; insulin-like growth factor I binding; protein kinase C binding; transforming growth factor beta binding; metal ion binding
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Biological Process: integrin-mediated signaling pathway; negative regulation of lipid transport; axon guidance; entry of virus into host cell; positive regulation of cell adhesion; negative regulation of lipoprotein metabolic process; cell-matrix adhesion; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; entry of symbiont into host cell by promotion of host phagocytosis; regulation of phagocytosis; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of osteoblast proliferation; positive regulation of cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; angiogenesis; cell adhesion; blood coagulation; leukocyte migration; apoptotic cell clearance; negative regulation of apoptosis; positive regulation of cell migration
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Reference #:
P06756 (UniProtKB)
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| Alt. Names/Synonyms: antigen identified by monoclonal antibody L230; CD51; DKFZp686A08142; Integrin alpha-V; Integrin alpha-V heavy chain; Integrin alpha-V light chain; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); ITAV; ITGAV; MSK8; Vitronectin receptor subunit alpha; VNRA |
| Gene Symbols: ITGAV |
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Molecular weight: 116,038 Da
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Basal Isoelectric point: 5.45
Predict pI for various phosphorylation states
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CST Pathways:
GPCRs Signaling to MAPK/Erk
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MAPK/Erk in Growth and Differentiation
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PI3K/Akt Signaling
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Regulation of Actin Dynamics
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