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Protein Page:
PLCG2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLCG2 a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. It is a crucial enzyme in transmembrane signaling. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Note: This description may include information from UniProtKB.
Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; EC 3.1.4.11
Chromosomal Location of Human Ortholog: 16q24.1
Cellular Component: plasma membrane; cytosol
Molecular Function: signal transducer activity; protein binding; phospholipase C activity; phosphoinositide phospholipase C activity
Biological Process: platelet activation; inositol phosphate metabolic process; Wnt receptor signaling pathway; phospholipid catabolic process; calcium-mediated signaling; response to lipopolysaccharide; T cell receptor signaling pathway; B cell receptor signaling pathway; activation of store-operated calcium channel activity; inositol trisphosphate biosynthetic process; regulation of gene expression; release of sequestered calcium ion into cytosol; B cell differentiation; phosphatidylinositol biosynthetic process; negative regulation of programmed cell death; innate immune response; follicular B cell differentiation; blood coagulation
Reference #:  P16885 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; phospholipase C gamma 2; phospholipase C, gamma 2 (phosphatidylinositol-specific); phospholipase C, gamma 2 (phosphatidylyinositol-specific); Phospholipase C-gamma-2; Phospholipase C-IV; PLC-gamma-2; PLC-IV; PLCG2
Gene Symbols: PLCG2
Molecular weight: 147,870 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLCG2

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y753‑p, Y759‑p
molecular association, regulation: Y753‑p, Y759‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T49 TVQVIMETRQVAWSK
0 4 S160-p VDQTRRNsISLRELK
0 1 K208-ub QFHLFYKkLMFEQQK
0 5 Y242-p RPDASAVyLHDFQRF
0 1 T276-p MTKFIDDtMRETAEP
0 42 Y371-p PDGKPVIyHGWTRTT
0 1 T375 PVIyHGWTRTTKIKF
0 4 K432-ub FGDLLLTkPTEASAD
0 12 Y482-p HKQQGELyMWDSIDQ
1 34 Y495-p DQKWTRHyCAIADAK
0 1 Y647-p PHESKPWyYDSLSRG
0 2 S677-p LIRKREGsDsyAItF
0 1 S679-p RKREGsDsyAItFRA
0 53 Y680-p KREGsDsyAItFRAR
0 1 T683-p GsDsyAItFRARGKV
0 1 Y720-p LVELVSYyEKHSLYR
0 3 Y733-p YRKMRLRyPVTPELL
0 1 Y743-p TPELLERyNMERDIN
7 277 Y753-p ERDINSLyDVsRMyV
0 4 S756-p INSLyDVsRMyVDPs
10 227 Y759-p LyDVsRMyVDPsEIN
0 1 S763-p sRMyVDPsEINPSMP
0 6 Y778-p QRTVKALyDyKAKRS
0 2 Y780-p TVKALyDyKAKRSDE
0 1 S789-p AKRSDELsFCRGALI
0 6 Y811-p GGWWKGDyGTRIQQy
0 13 Y818-p yGTRIQQyFPSNYVE
0 1 Y823 QQyFPSNYVEDISTA
0 4 T857-p RGILDLNtyNVVKAP
0 15 Y858-p GILDLNtyNVVKAPQ
0 8 Y936-p ELSDLVVyCKPTsKT
0 1 S941-p VVyCKPTsKTKDNLE
0 1 S957-p PDFREIRsFVETkAD
0 1 K962-ub IRsFVETkADsIIRQ
0 1 S965-p FVETkADsIIRQKPV
0 1 S994-p PKGQRVDsSNYDPFR
0 1 S1007-p FRLWLCGsQMVALNF
0 1 T1016-p MVALNFQtADKyMQM
0 2 Y1020-p NFQtADKyMQMNHAL
0 3 S1029-p QMNHALFsLNGRtGy
0 1 T1034-p LFsLNGRtGyVLQPE
0 1 Y1036-p sLNGRtGyVLQPESM
1 0 T1045-p LQPESMRtEKyDPMP
0 2 Y1048-p ESMRtEKyDPMPPES
0 1 T1062-p SQRKILMtLtVKVLG
0 1 T1064-p RKILMtLtVKVLGAR
0 2 Y1137-p AFLRFVVyEEDMFSD
1 0 S1164-p AVKSGFRsVPLKNGY
3 86 Y1197-p LESEEELySSCRQLR
7 347 Y1217-p LNNQLFLyDtHQNLR
0 16 T1219-p NQLFLyDtHQNLRNA
0 1 K1233-ub ANRDALVkEFSVNEN
0 148 Y1245-p NENQLQLyQEKCNKR
0 22 S1259-p RLREKRVsNsKFys_
0 2 S1261-p REKRVsNsKFys___
0 44 Y1264-p RVsNsKFys______
0 3 S1265-p VsNsKFys_______
3874 : Phospho-PLCgamma2 (Tyr759) Antibody
3871 : Phospho-PLCgamma2 (Tyr1217) Antibody
  mouse

 
T49-p TVQMIMEtRQVAWSK
S160-p VDQTRRNsISLRELK
K208 QFHLFYKKLMFDQQK
Y242-p RPDASAVyLQDFQRF
T276 MTKFIDDTMRETAEP
Y371-p PDGKPIIyHGWtRTT
T375-p PIIyHGWtRTTKIKF
K432 LGDMLLTKPTEASAD
Y482-p HKPQGELyMWDSIDQ
Y495-p DQKWTRHyCAIADAK
Y647 PHESKPWYYDSLSRG
T677 LIRKREGTNSyAITF
S679 RKREGTNSyAITFRA
Y680-p KREGTNSyAITFRAR
T683 GTNSyAITFRARGKV
Y720 LVELVSYYEKHALYR
Y733 YRKMRLRYPVTPELL
Y743 TPELLERYNMERDIN
Y753-p ERDINSLyDVSRMyV
S756 INSLyDVSRMyVDPS
Y759-p LyDVSRMyVDPSEIN
S763 SRMyVDPSEINPSMP
Y778 QRTVKALYDYKAKRS
Y780 TVKALYDYKAKRSDE
T789 AKRSDELTFCRGALI
Y811-p GGWWKGDyGTRIQQy
Y818-p yGTRIQQyFPSNyVE
Y823-p QQyFPSNyVEDISAG
T857 KGILDLNTYNVVKAP
Y858 GILDLNTYNVVKAPQ
Y936 ELSDLVVYCKPTSKT
S941 VVYCKPTSKTKDHLE
S957 PDFREIRSFVETKAD
K962 IRSFVETKADSIVRQ
S965 FVETKADSIVRQKPV
S994 PKGQRVDSSNYDPFR
S1007 FRLWLCGSQMVALNF
T1016 MVALNFQTPDKYMQM
Y1020 NFQTPDKYMQMNHAL
S1029 QMNHALFSLNGRTGY
T1034 LFSLNGRTGYVLQPE
Y1036 SLNGRTGYVLQPESM
S1045 LQPESMRSEKYDPMP
Y1048 ESMRSEKYDPMPLES
T1062 SQRKILMTLTVKVLG
T1064 RKILMTLTVKVLGAR
Y1137 AFLRFVVYEEDMFSD
S1164 GIKSGFRSVPLKNGY
Y1197-p LESEEELySSCRQLR
Y1217-p LNNQLFLyDTHQNLR
T1219 NQLFLyDTHQNLRGA
K1233 ANRDALVKEFNVNEN
Y1245-p NENQLQLyQEKCNRR
S1259-p RLREKRVsNsRFYS_
S1261-p REKRVsNsRFYS___
Y1264 RVsNsRFYS______
S1265 VsNsRFYS_______
3874 : Phospho-PLCgamma2 (Tyr759) Antibody
3871 : Phospho-PLCgamma2 (Tyr1217) Antibody
  rat

 
T49 TVQMIMETRQVAWSK
S160 VDQTRRNSISLRELK
K208 QFHLFYKKLMFEQQK
Y242 RPDASAVYLQDFQRF
T276 MTKFIDDTMRETAEP
Y371 PDGKPIIYHGWTRTT
T375 PIIYHGWTRTTKIKF
K432 LGDLLLTKPTEASAD
Y482 HKTQGELYMWDSIDQ
Y495 DQKWTRHYCAIADAK
Y647 PHESKPWYYDRLSRG
T677 LIRKREGTDSYAITF
S679 RKREGTDSYAITFRA
Y680 KREGTDSYAITFRAR
T683 GTDSYAITFRARGKV
Y720 LVELVSYYEKHALYR
Y733 YRKMRLRYPVTPELL
Y743 TPELLERYNMERDIN
Y753-p ERDINSLyDVSRMyV
S756 INSLyDVSRMyVDPS
Y759-p LyDVSRMyVDPSEIN
S763 SRMyVDPSEINPSMP
Y778 QRTVKALYDYKAKRS
Y780 TVKALYDYKAKRSDE
T789 AKRSDELTFCRGALI
Y811 GGWWKGDYGTRIQQY
Y818 YGTRIQQYFPSNYVE
Y823 QQYFPSNYVEDISAG
T857 RGILDLNTYNVVKAP
Y858 GILDLNTYNVVKAPQ
Y936-p ELSDLVVyCKPTSKT
S941 VVyCKPTSKTKDHLE
S957 PDFREIRSFVETKAD
K962 IRSFVETKADSIVRQ
S965 FVETKADSIVRQKPV
S994 PKGQRVDSSNYDPFR
S1007 FRLWLCGSQMVALNF
T1016 MVALNFQTPDKYMQM
Y1020 NFQTPDKYMQMNHAL
S1029 QMNHALFSLNGRTGY
T1034 LFSLNGRTGYVLQPE
Y1036 SLNGRTGYVLQPESM
S1045 LQPESMRSEKYDPMP
Y1048 ESMRSEKYDPMPPES
T1062 SQRKILMTLTVKVLG
T1064 RKILMTLTVKVLGAR
Y1137 AFLRFLVYEEDMFSD
S1164 GIKSGFRSVPLKNGY
Y1197-p LESEEELySSCRQLR
Y1217-p LNNQLFLyDTHQNLR
T1219 NQLFLyDTHQNLRGA
K1233 ANRDALVKEFNVNEN
Y1245 NENQLRLYQEKCNRR
S1259 RLREKRVSNSRFYS_
S1261 REKRVSNSRFYS___
Y1264 RVSNSRFYS______
S1265 VSNSRFYS_______
3874 : Phospho-PLCgamma2 (Tyr759) Antibody
3871 : Phospho-PLCgamma2 (Tyr1217) Antibody
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