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Protein Page:
BAZ1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BAZ1A Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end- positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. Component of the ACF chromatin remodeling complex that includes BAZ1A and SMARCA5. Additional this complex can form, together with CHRAC1 and POLE1, the histone-fold protein complex, CHRAC. Interacts with NCOR1 (via its RD1 domain); the interaction corepresses a number of NCOR1-regulated genes. Highly expressed in testis and at low or undetectable levels in other tissues analyzed. Belongs to the WAL family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); DNA replication; DNA binding protein; Kinase, protein; ATYPICAL group; BAZ family
Cellular Component: nuclear chromosome; chromatin accessibility complex
Molecular Function: protein binding; histone acetyltransferase activity; zinc ion binding
Biological Process: chromatin remodeling; transcription, DNA-dependent; regulation of transcription, DNA-dependent; DNA-dependent DNA replication
Reference #:  Q9NRL2 (UniProtKB)
Alt. Names/Synonyms: ACF1; ATP-dependent chromatin remodeling protein; ATP-dependent chromatin-remodeling protein; ATP-utilizing chromatin assembly and remodeling factor 1; BAZ1A; Bromodomain adjacent to zinc finger domain protein 1A; bromodomain adjacent to zinc finger domain, 1A; CHRAC subunit ACF1; DKFZp586E0518; FLJ14383; hACF1; hWALp1; WALp1; WCRF180; Williams syndrome transcription factor-related chromatin-remodeling factor 180
Gene Symbols: BAZ1A
Molecular weight: 178,702 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BAZ1A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S169 IISDSDDSETQSCSF
0 1 T171 SDSDDSETQSCSFQN
0 3 S270-p DPPTFIFsPANRRRG
0 7 H284 GRPPKRIHIsQEDNV
0 7 S286-p PPKRIHIsQEDNVAN
0 1 N293 sQEDNVANKQTLASY
0 1 K331-ub KAKLKREkADALEAK
0 1 K339-ub ADALEAKkKEKEDKE
0 1 K387-ub KLREEKRkYVEYLKQ
0 1 K570-ub DVTSANAkYRYQKRG
0 1 S595-p ELRLSNPsLVKKLSS
0 1 Y606-p KLSSTSVyDLTPGEK
0 1 S702-p RNSTADIsIGEEERE
0 4 T713 EEREDFDTSIESKDT
0 3 S714 EREDFDTSIESKDTE
0 47 T731-p ELDQDMVtEDEDDPG
0 1 S739-p EDEDDPGsHKRGRRG
0 8 S850-p SFQNNVQsQDPQVST
0 2 K919-ac GHRESALkETLLQEK
0 1 S951 SDKPQPDSKPTYSRG
0 4 S960-p PTYSRGRssNAyDPS
0 6 S961-p TYSRGRssNAyDPSQ
0 2 Y964-p RGRssNAyDPSQMCA
0 1 K973-ac PSQMCAEkQLELRLR
0 5 S1205-p KQRSRRLsSRQRPSL
0 2 S1252-p VEQDEDDsQEEEEVS
0 5 S1279-p VKTRGKLsssFssRG
0 3 S1280-p KTRGKLsssFssRGQ
0 3 S1281-p TRGKLsssFssRGQQ
0 3 S1283-p GKLsssFssRGQQQE
0 1 S1284-p KLsssFssRGQQQEP
0 2 Y1294-p QQQEPGRyPsRSQQs
0 2 S1296-p QEPGRyPsRSQQstP
0 1 S1301-p yPsRSQQstPKTTVS
0 8 T1302-p PsRSQQstPKTTVSS
0 1 T1311-p KTTVSSKtGRSLRKI
1 4 S1320-p RSLRKINsAPPtETK
0 1 T1324-p KINsAPPtETKSLRI
0 7 S1339-p ASRSTRHsHGPLQAD
0 2 G1341 RSTRHsHGPLQADVF
0 10 S1353-p DVFVELLsPRRKRRG
0 29 S1363-p RKRRGRKsANNtPEN
0 33 T1367-p GRKsANNtPENsPNF
0 28 S1371-p ANNtPENsPNFPNFR
0 1 T1382-p PNFRVIAtKSSEQSR
0 1 S1395-p SRSVNIAsKLsLQEs
0 1 S1398-p VNIAsKLsLQEsESK
0 6 S1402-p sKLsLQEsESKRRCR
0 34 S1413-p RRCRKRQsPEPsPVT
0 3 P1414 RCRKRQsPEPsPVTL
0 2 P1416 RKRQsPEPsPVTLGR
0 14 S1417-p KRQsPEPsPVTLGRR
0 1 S1426-p VTLGRRSsGRQGGVH
0 1 Y1467-p KIQVPDYyDIIKKPI
0 4 T1538-p QKLGLHVtPsNVDQV
0 1 S1540-p LGLHVtPsNVDQVSt
0 1 N1541 GLHVtPsNVDQVStP
0 37 T1547-p sNVDQVStPPAAkKS
0 2 K1552-ac VStPPAAkKSRI___
  mouse

► Hide Isoforms
 
S169-p VISDSDDsEtQSSSF
T171-p SDSDDsEtQSSSFHH
S270 DPPTFIFSPANRRRG
S284-p GRPPKRIsFGQEDSI
G286 PPKRIsFGQEDSIAs
S293-p GQEDSIAsKQTAARY
R331 KAKLKRERADALEAR
K339 ADALEARKREKEDKE
K387 KLREEKRKYMEYLKQ
K571 DVTSANAKYRYQKRG
S596 ELRLSNPSLVKKLSS
Y607 KLSSTSVYDLTPGEK
G703 RNSAAVPGYGEEERE
T714 EEREDFDTSTENKNI
S715 EREDFDTSTENKNIE
T732-p DLDPDVVtEDEDDPG
S740-p EDEDDPGsHKRSRRG
P852 SFHNNAQPRDPQVSI
K921 GHRESALKETLLQEK
S953-p SDKPQADsKPVSSRG
S962-p PVSSRGRssGACDIS
S963-p VSSRGRssGACDISQ
C966 RGRssGACDISQMSA
R975 ISQMSAERQLELRLR
S1206 KQRSRRLSSRQRPSL
S1253 VEQDEEDSDDDEALS
G1280 IKTKGRFGPSFPSRS
P1281 KTKGRFGPSFPSRSQ
S1282 TKGRFGPSFPSRSQR
S1285 RFGPSFPSRSQRQDP
- gap
Y1295 QRQDPGRYPSRSQQS
S1297 QDPGRYPSRSQQSTP
S1302 YPSRSQQSTPKNTAK
T1303 PSRSQQSTPKNTAKS
S1312 KNTAKSASKNLRKTR
S1320 KNLRKTRSAPPTETR
T1324 KTRSAPPTETRSLRV
S1339-p GSRSTRHsPsALQDV
S1341-p RSTRHsPsALQDVFV
S1352-p DVFVELLsPHSKRRG
G1362 SKRRGRKGADHtPEH
T1366-p GRKGADHtPEHsPSF
S1370-p ADHtPEHsPSFTNFR
S1381 TNFRVSTSRSSRQLI
- gap
S1397 LNTAESLSLQHSESK
S1401 ESLSLQHSESKRRGR
S1412-p RRGRKRQstEssPVP
T1413-p RGRKRQstEssPVPL
S1415-p RKRQstEssPVPLNR
S1416-p KRQstEssPVPLNRR
S1425 VPLNRRSSGRQGGVH
Y1466 KIQVPDYYDIIKKPI
S1537-p QKLGLHVsPStVDQV
S1539 LGLHVsPStVDQVSt
T1540-p GLHVsPStVDQVStP
T1546-p StVDQVStPLAAKKS
K1551 VStPLAAKKSRI___
  BAZ1A iso3  
S169 VISDSDDSETQSSSF
T171 SDSDDSETQSSSFHH
S270 DPPTFIFSPANRRRG
S284 GRPPKRISFGQEDSI
G286 PPKRISFGQEDSIAS
S293 GQEDSIASKQTAARY
R331 KAKLKRERADALEAR
K339 ADALEARKREKEDKE
K387 KLREEKRKYMEYLKQ
K570 DVTSANAKYRYQKRG
S595 ELRLSNPSLVKKLSS
Y606 KLSSTSVYDLTPGEK
- gap
T711-p EEREDFDtsTENKNI
S712-p EREDFDtsTENKNIE
T729 DLDPDVVTEDEDDPG
S737 EDEDDPGSHKRSRRG
P849 SFHNNAQPRDPQVSI
K918 GHRESALKETLLQEK
S950 SDKPQADSKPVSSRG
S959 PVSSRGRSSGACDIS
S960 VSSRGRSSGACDISQ
C963 RGRSSGACDISQMSA
R972 ISQMSAERQLELRLR
S1203 KQRSRRLSSRQRPSL
S1250 VEQDEEDSDDDEALS
G1277 IKTKGRFGPSFPSRS
P1278 KTKGRFGPSFPSRSQ
S1279 TKGRFGPSFPSRSQR
S1282 RFGPSFPSRSQRQDP
- gap
Y1292 QRQDPGRYPSRSQQS
S1294 QDPGRYPSRSQQSTP
S1299 YPSRSQQSTPKNTAK
T1300 PSRSQQSTPKNTAKS
S1309 KNTAKSASKNLRKTR
S1317 KNLRKTRSAPPTETR
T1321 KTRSAPPTETRSLRV
S1336 GSRSTRHSPSALQDV
S1338 RSTRHSPSALQDVFV
S1349 DVFVELLSPHSKRRG
G1359 SKRRGRKGADHTPEH
T1363 GRKGADHTPEHSPSF
S1367 ADHTPEHSPSFTNFR
S1378 TNFRVSTSRSSRQLI
- gap
S1394 LNTAESLSLQHSESK
S1398 ESLSLQHSESKRRGR
S1409 RRGRKRQSTESSPVP
T1410 RGRKRQSTESSPVPL
S1412 RKRQSTESSPVPLNR
S1413 KRQSTESSPVPLNRR
S1422 VPLNRRSSGRQGGVH
Y1463 KIQVPDYYDIIKKPI
S1534 QKLGLHVSPSTVDQV
S1536 LGLHVSPSTVDQVST
T1537 GLHVSPSTVDQVSTP
T1543 STVDQVSTPLAAKKS
K1548 VSTPLAAKKSRI___
  rat

 
S169 VISDSDDSETQSSSF
T171 SDSDDSETQSSSFQH
S270 DPPTFIFSPANRRRG
S284-p GRPPKRIsFGQEDNI
G286 PPKRIsFGQEDNIAS
S293 GQEDNIASKQTIARC
K331 KAKLKREKADALEAR
K339 ADALEARKREREDRE
K387 KLREEKRKYMEYLKQ
K570 DVTSANAKYRYQKRG
S595 ELRLSNPSLVKKLSS
Y606 KLSSTAVYDLTPGEK
- gap
T711 EGREDFDTSADSKEI
S712 GREDFDTSADSKEIE
T729-p DLDPDVVtEDEDDLG
S737 EDEDDLGSHKRSRRG
P849 SFHSNAQPHSPRVSI
K918 GHRESALKETLLQEK
S950 SDKPQADSKPVSSRG
S959 PVSSRGRSAACDTSQ
- gap
C962 SRGRSAACDTSQMSA
R971 TSQMSAERQLELRLR
S1202 KQRSRRLSSRQRPSL
S1249 VEQDEEDSDEEEALS
G1276 IKTRGRFGPSFSSRS
P1277 KTRGRFGPSFSSRSQ
S1278 TRGRFGPSFSSRSQR
S1280 GRFGPSFSSRSQRQD
S1281 RFGPSFSSRSQRQDP
Y1291 QRQDPGRYPSRSQQS
S1293 QDPGRYPSRSQQSTP
S1298 YPSRSQQSTPKTTAS
T1299 PSRSQQSTPKTTASK
A1308 KTTASKTAGRNLRKT
S1317 RNLRKTRSAPPTETR
T1321 KTRSAPPTETRSLRL
S1336 GSRSTRHSPNALQAD
N1338 RSTRHSPNALQADVF
S1350 DVFVELLSPRGKRRV
S1360-p GKRRVRKsADNtPEH
T1364-p VRKsADNtPEHsPSL
S1368-p ADNtPEHsPSLTNLR
S1379 TNLRVSTSRPSVQLI
- gap
S1395 LNSAERLSLQDSESK
S1399 ERLSLQDSESKRRGR
S1410-p RRGRKRQsTESsPVP
T1411 RGRKRQsTESsPVPL
S1413 RKRQsTESsPVPLNR
S1414-p KRQsTESsPVPLNRR
S1423 VPLNRRSSGRQGGVH
Y1464 KIQVPDYYDIIKKPI
S1535 QKLGLHVSPSNVDQA
S1537 LGLHVSPSNVDQAST
N1538 GLHVSPSNVDQASTP
T1544 SNVDQASTPLAAKKS
K1549 ASTPLAAKKSRI___
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