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UNC80 (human)

Overview UNC80 Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability. Belongs to the unc-80 family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: integral to membrane Reference #:  Q8N2C7 (UniProtKB) Alt. Names/Synonyms: C2orf21; FLJ14677; FLJ33496; FLJ53903; KIAA1843; Protein unc-80 homolog; UNC-80; unc-80 homolog (C. elegans); UNC80; WUGSC:H_NH0436C12.1 Gene Symbols: UNC80 Molecular weight: 363,390 Da Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states

Select Structure to View Below UNC80

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S7	_MVKRKSSEGQEQDG
0	1		S62	ENKLHGLSPALSEAI
0	1		S157	HQVENQGSPGQPCQS
0	2		S246	IITAKRSSPINSQSR
0	5		S257	SQSRTCESPNQDARH
0	2		S294-p	SGCHRGNsFDGSLSS
0	1		S392-p	SMVAAAPsLVNTHKT
0	1		S414	NEEEKSLSSEAFSKV
0	1		S422	SEAFSKVSLTNLRRS
0	1		T424	AFSKVSLTNLRRSAV
0	1		S498	TFSFGSFSGLGEDRR
0	2		S525	GKLTRRGSSDAATEM
0	1		T623	ANLPRSLTDSCINYS
0	2		S654-p	KNGMLDLsVVLKAVY
0	1		T791-p	SNHRLALtMLIKIVK
0	1		S799-p	MLIKIVKsLGCAYGC
0	1		S907	IVSAMFKSLITRCAS
0	1		T910	AMFKSLITRCASTTH
0	1		S1009	SFMSGRPSQTPEHDE
0	1		T1011	MSGRPSQTPEHDEQM
0	1		S1058-p	SECTTAHsGTTSDRR
0	1		S1157	FKRLGCHSFDDHLSP
0	1		S1163	HSFDDHLSPNQDGGK
0	1		K1250-u	GHHVNITkKGLSRGR
0	1		-	gap
0	1		-	gap
0	1		T1537	SDKSCLRTPSLKKRV
0	1		S1539	KSCLRTPSLKKRVSD
0	1		S1790	NLASRRLSVSPSCTS
0	1		Y1804-p	SSTSHRNysFRRGSV
0	1		S1805-p	STSHRNysFRRGSVW
0	1		S1810	NysFRRGSVWSVRSA
0	1		S1813	FRRGSVWSVRSAVSA
0	1		S2136-p	RLPSFPRsAIDAEFS
0	1		T2236	GYQWILPTMLQVYSD
0	1		Y2241	LPTMLQVYSDYESNP
0	1		K2512	KHCGPRLKILQNLAG
0	1		K2532	ALELLDVKSHMRLAE
0	2		S3042	GSLSRVASIQSEPGQ
0	2		S3045	SRVASIQSEPGQQNL
0	1		S3073	QLRRPLLSRQKTQTE
0	1		T3130	PTDALPATGQLQGCS
0	1		S3167	VADLHSVSPKQSENF

	mouse ► Hide Isoforms
S7-p	_MVKRKSsEGQEQDG
S62-p	ENKLHGLsPALSEAI
S157-p	HQIENQGsPGQPCRS
S246-p	IITAKRSsPINSQSQ
S257-p	SQSQTCEsPNQDTRQ
S295-p	SGCHQGNsFDGSLSS
S393	SMVAAAPSLVNTHKT
S415-p	NEEEKSLsPEAFSKV
S423-p	PEAFSKVsLtNLRRS
T425-p	AFSKVsLtNLRRSAV
S499-p	TFSFGSFsGLGEDRR
S526-p	GKLTRRGsSDAATEM
T624-p	ANLPRSLtDSCINYS
S655	KNGMLDLSVVLKAVY
T794	SNHRLALTMLIKIVK
S802	MLIKIVKSLGCAYGC
S910-p	IVGAMFKsLItRCAS
T913-p	AMFKsLItRCASTTH
S1012-p	SFMSGRPsQtPEHDE
T1014-p	MSGRPsQtPEHDEPM
S1061	SECTTAHSGNTSDRR
S1160-p	FKRLGCHsFDDHLsP
S1166-p	HsFDDHLsPNQDGGK
K1253	GHHVNITKKGLSRGR
-	gap
-	gap
T1540-p	SDKSCLRtPsLKKRV
S1542-p	KSCLRtPsLKKRVSD
S1793-p	NLTSRRLsVSPSCTS
Y1807	SSTSHRNYSFRRGsV
S1808	STSHRNYSFRRGsVW
S1813-p	NYSFRRGsVWsVRSA
S1816-p	FRRGsVWsVRSAVSA
S2139	RLPSFPRSAIDAEFS
T2239-p	GYQWILPtMLQVySD
Y2244-p	LPtMLQVySDYESNP
K2515-u	KHCGPRLkILQNLAG
K2535-u	ALELLDVkSHMRLAE
S3045-p	GSLSRVAsIQsEPGQ
S3048-p	SRVAsIQsEPGQQNV
S3076-p	QLRRPLLsRQKTQTE
T3133-p	PTDIFPAtGQPQSCS
S3170-p	IADLHSLsPKQSEPL

	UNC80 iso2
S7	_MVKRKSSEGQEQDG
S62	ENKLHGLSPALSEAI
S157	HQIENQGSPGQPCRS
S246	IITAKRSSPINSQSQ
S257	SQSQTCESPNQDTRQ
S295	SGCHQGNSFDGSLSS
S393	SMVAAAPSLVNTHKT
S415	NEEEKSLSPEAFSKV
S423	PEAFSKVSLTNLRRS
T425	AFSKVSLTNLRRSAV
S499	TFSFGSFSGLGEDRR
S526	GKLTRRGSSDAATEM
T624	ANLPRSLTDSCINYS
S655	KNGMLDLSVVLKAVY
T794	SNHRLALTMLIKIVK
S802	MLIKIVKSLGCAYGC
S910	IVGAMFKSLITRCAS
T913	AMFKSLITRCASTTH
S1012	SFMSGRPSQTPEHDE
T1014	MSGRPSQTPEHDEPM
S1061	SECTTAHSGNTSDRR
S1158	FKRLGCHSFDDHLSP
S1164	HSFDDHLSPNQDGGK
K1251	GHHVNITKKGLSRGR
S1457-p	FQVKKGGsLsSIRRV
S1459-p	VKKGGsLsSIRRVGS
T1606	SDKSCLRTPSLKKRV
S1608	KSCLRTPSLKKRVSD
S1858	NLTSRRLSVSPSCTS
Y1872	SSTSHRNYSFRRGSV
S1873	STSHRNYSFRRGSVW
S1878	NYSFRRGSVWSVRSA
S1881	FRRGSVWSVRSAVSA
S2204	RLPSFPRSAIDAEFS
T2304	GYQWILPTMLQVYSD
Y2309	LPTMLQVYSDYESNP
K2580	KHCGPRLKILQNLAG
K2600	ALELLDVKSHMRLAE
S3110	GSLSRVASIQSEPGQ
S3113	SRVASIQSEPGQQNV
S3141	QLRRPLLSRQKTQTE
T3198	PTDIFPATGQPQSCS
S3235	IADLHSLSPKQSEPL

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