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Protein Page:
UNC80 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UNC80 Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability. Belongs to the unc-80 family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: integral to membrane; plasma membrane
Biological Process: transmembrane transport
Reference #:  Q8N2C7 (UniProtKB)
Alt. Names/Synonyms: C2orf21; FLJ14677; FLJ33496; FLJ53903; KIAA1843; Protein unc-80 homolog; UNC-80; unc-80 homolog (C. elegans); UNC80; WUGSC:H_NH0436C12.1
Gene Symbols: UNC80
Molecular weight: 363,390 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
Select Structure to View Below

UNC80

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7 _MVKRKSSEGQEQDG
0 1 S62 ENKLHGLSPALSEAI
0 1 S157 HQVENQGSPGQPCQS
0 2 S246 IITAKRSSPINSQSR
0 5 S257 SQSRTCESPNQDARH
0 2 S294-p SGCHRGNsFDGSLSS
0 1 S392-p SMVAAAPsLVNTHKT
0 1 S414 NEEEKSLSSEAFSKV
0 1 S422 SEAFSKVSLTNLRRS
0 1 T424 AFSKVSLTNLRRSAV
0 1 S498 TFSFGSFSGLGEDRR
0 2 S525 GKLTRRGSSDAATEM
0 1 T623 ANLPRSLTDSCINYS
0 2 S654-p KNGMLDLsVVLKAVY
0 1 T791-p SNHRLALtMLIKIVK
0 1 S799-p MLIKIVKsLGCAYGC
0 1 S907 IVSAMFKSLITRCAS
0 1 T910 AMFKSLITRCASTTH
0 1 S982-p KPAGSKRsEAGSIVD
0 1 S1009 SFMSGRPSQTPEHDE
0 1 T1011 MSGRPSQTPEHDEQM
0 1 S1058-p SECTTAHsGTTSDRR
0 1 S1137-p LSEGGPGsGMENGRD
0 1 S1157 FKRLGCHSFDDHLSP
0 1 S1163 HSFDDHLSPNQDGGK
0 1 K1250-ub GHHVNITkKGLSRGR
0 1 S1258-p KGLSRGRsPIVGNKR
0 1 - gap
0 1 - gap
0 1 T1537 SDKSCLRTPSLKKRV
0 1 S1539 KSCLRTPSLKKRVSD
0 1 S1790 NLASRRLSVSPSCTS
0 1 Y1804-p SSTSHRNysFRRGSV
0 1 S1805-p STSHRNysFRRGSVW
0 1 S1810 NysFRRGSVWSVRSA
0 1 S1813 FRRGSVWSVRSAVSA
0 1 S2136-p RLPSFPRsAIDAEFS
0 1 T2236 GYQWILPTMLQVYSD
0 1 Y2241 LPTMLQVYSDYESNP
0 1 K2512 KHCGPRLKILQNLAG
0 1 K2532 ALELLDVKSHMRLAE
0 1 T2923-p QGKTSIStVGtSTsA
0 1 T2926-p TSIStVGtSTsAyRL
0 1 S2929-p StVGtSTsAyRLSLA
0 1 Y2931-p VGtSTsAyRLSLATM
0 2 S3042 GSLSRVASIQSEPGQ
0 2 S3045 SRVASIQSEPGQQNL
0 1 S3073 QLRRPLLSRQKTQTE
0 1 T3130 PTDALPATGQLQGCS
0 1 S3167 VADLHSVSPKQSENF
  mouse

► Hide Isoforms
 
S7-p _MVKRKSsEGQEQDG
S62-p ENKLHGLsPALSEAI
S157-p HQIENQGsPGQPCRS
S246-p IITAKRSsPINSQSQ
S257-p SQSQTCEsPNQDTRQ
S295-p SGCHQGNsFDGSLSS
S393 SMVAAAPSLVNTHKT
S415-p NEEEKSLsPEAFSKV
S423-p PEAFSKVsLtNLRRS
T425-p AFSKVsLtNLRRSAV
S499-p TFSFGSFsGLGEDRR
S526-p GKLTRRGsSDAATEM
T624-p ANLPRSLtDSCINYS
S655 KNGMLDLSVVLKAVY
T794 SNHRLALTMLIKIVK
S802 MLIKIVKSLGCAYGC
S910-p IVGAMFKsLItRCAS
T913-p AMFKsLItRCASTTH
S985 KPVGSKRSEAGSIAD
S1012-p SFMSGRPsQtPEHDE
T1014-p MSGRPsQtPEHDEPM
S1061 SECTTAHSGNTSDRR
S1140 LSEGGPGSGMENGRE
S1160-p FKRLGCHsFDDHLsP
S1166-p HsFDDHLsPNQDGGK
K1253 GHHVNITKKGLSRGR
S1261 KGLSRGRSPTVGNKR
- gap
- gap
T1540-p SDKSCLRtPsLKKRV
S1542-p KSCLRtPsLKKRVSD
S1793-p NLTSRRLsVSPSCTS
Y1807 SSTSHRNYSFRRGsV
S1808 STSHRNYSFRRGsVW
S1813-p NYSFRRGsVWsVRSA
S1816-p FRRGsVWsVRSAVSA
S2139 RLPSFPRSAIDAEFS
T2239-p GYQWILPtMLQVySD
Y2244-p LPtMLQVySDYESNP
K2515-ub KHCGPRLkILQNLAG
K2535-ub ALELLDVkSHMRLAE
T2926 QGKTSISTVGTSTSA
T2929 TSISTVGTSTSAYRL
S2932 STVGTSTSAYRLSLA
Y2934 VGTSTSAYRLSLATM
S3045-p GSLSRVAsIQsEPGQ
S3048-p SRVAsIQsEPGQQNV
S3076-p QLRRPLLsRQKTQTE
T3133-p PTDIFPAtGQPQSCS
S3170-p IADLHSLsPKQSEPL
  UNC80 iso2  
S7 _MVKRKSSEGQEQDG
S62 ENKLHGLSPALSEAI
S157 HQIENQGSPGQPCRS
S246 IITAKRSSPINSQSQ
S257 SQSQTCESPNQDTRQ
S295 SGCHQGNSFDGSLSS
S393 SMVAAAPSLVNTHKT
S415 NEEEKSLSPEAFSKV
S423 PEAFSKVSLTNLRRS
T425 AFSKVSLTNLRRSAV
S499 TFSFGSFSGLGEDRR
S526 GKLTRRGSSDAATEM
T624 ANLPRSLTDSCINYS
S655 KNGMLDLSVVLKAVY
T794 SNHRLALTMLIKIVK
S802 MLIKIVKSLGCAYGC
S910 IVGAMFKSLITRCAS
T913 AMFKSLITRCASTTH
S985 KPVGSKRSEAGSIAD
S1012 SFMSGRPSQTPEHDE
T1014 MSGRPSQTPEHDEPM
S1061 SECTTAHSGNTSDRR
S1138 LSEGGPGSGMENGRE
S1158 FKRLGCHSFDDHLSP
S1164 HSFDDHLSPNQDGGK
K1251 GHHVNITKKGLSRGR
S1259 KGLSRGRSPTVGNKR
S1457-p FQVKKGGsLsSIRRV
S1459-p VKKGGsLsSIRRVGS
T1606 SDKSCLRTPSLKKRV
S1608 KSCLRTPSLKKRVSD
S1858 NLTSRRLSVSPSCTS
Y1872 SSTSHRNYSFRRGSV
S1873 STSHRNYSFRRGSVW
S1878 NYSFRRGSVWSVRSA
S1881 FRRGSVWSVRSAVSA
S2204 RLPSFPRSAIDAEFS
T2304 GYQWILPTMLQVYSD
Y2309 LPTMLQVYSDYESNP
K2580 KHCGPRLKILQNLAG
K2600 ALELLDVKSHMRLAE
T2991 QGKTSISTVGTSTSA
T2994 TSISTVGTSTSAYRL
S2997 STVGTSTSAYRLSLA
Y2999 VGTSTSAYRLSLATM
S3110 GSLSRVASIQSEPGQ
S3113 SRVASIQSEPGQQNV
S3141 QLRRPLLSRQKTQTE
T3198 PTDIFPATGQPQSCS
S3235 IADLHSLSPKQSEPL
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