a member of the MPI phosphatase family. Functions as a dosage-dependent inducer in mitotic control.. Required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; EC 18.104.22.168
Chromosomal Location of Human Ortholog: 3p21
Cellular Component: nucleoplasm; cytosol
Molecular Function: protein binding; protein tyrosine phosphatase activity; protein kinase binding
Biological Process: cell proliferation; mitosis; response to radiation; regulation of cell cycle; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.