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Protein Page:
POU6F2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

POU6F2 Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. Defects in POU6F2 are a cause of hereditary susceptibility to Wilms tumor 5 (WT5). WT5 is a pediatric malignancy of kidney and one of the most common solid cancers in childhood. Belongs to the POU transcription factor family. Class- 6 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 7p14.1
Cellular Component: nucleus
Molecular Function: DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; central nervous system development; visual perception; regulation of transcription, DNA-dependent; ganglion mother cell fate determination
Disease: Wilms Tumor 5
Reference #:  P78424 (UniProtKB)
Alt. Names/Synonyms: POU class 6 homeobox 2; POU domain, class 6, transcription factor 2; POU6F2; retina-derived POU domain factor 1; retina-derived POU-domain factor-1; RPF-1; Wilms tumor suppressor locus; WT5; WTSL
Gene Symbols: POU6F2
Molecular weight: 73,265 Da
Basal Isoelectric point: 7.31  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 1 K16-ub MIAGQVSkPLLsVRs

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