Home

Snail2 (human)

Overview Snail2 Transcriptional repressor. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle. Belongs to the snail C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; C2H2-type zinc finger protein; Transcription factor; Apoptosis Cellular Component: nuclear chromatin; cytoplasm; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; zinc ion binding; sequence-specific DNA binding; chromatin binding Biological Process: substrate-bound cell migration, cell release from substrate; Notch signaling pathway; neural crest cell development; regulation of osteoblast differentiation; negative regulation of chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; palate development; osteoblast differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; sensory perception of sound; pigmentation; white fat cell differentiation; epithelial to mesenchymal transition; positive regulation of fat cell differentiation; positive regulation of histone acetylation; regulation of chemokine production; negative regulation of cell adhesion mediated by integrin; positive regulation of cell migration; negative regulation of apoptosis Reference #:  O43623 (UniProtKB) Alt. Names/Synonyms: MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; SLUG; slug (chicken homolog), zinc finger protein; SLUGH; SLUGH1; SNAI2; snail 2; snail homolog 2 (Drosophila); WS2D; Zinc finger protein SNAI2 Gene Symbols: SNAI2 Molecular weight: 29,986 Da Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Snail2

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Sites Implicated In
transcription, induced: S92‑p, S96‑p, S100‑p intracellular localization: S92‑p, S96‑p, S100‑p protein degradation: S92‑p, S96‑p, S100‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S4	____MPRSFLVKKHF
2	0		S87-p	SSSLGRVsPPPPsDT
1	0		S92-p	RVsPPPPsDTSsKDH
1	0		S96-p	PPPsDTSsKDHsGSE
1	0		S100-p	DTSsKDHsGSEsPIS
1	0		S104-p	KDHsGSEsPISDEEE
0	1		T136-p	QCNLCNKtYSTFSGL
0	1		K175-u	YVSLGALkMHIRTHT

	mouse
S4-p	____MPRsFLVKKHF
S88-p	SSSLGRVsPPPSSDT
S93	RVsPPPSSDTSSKDH
S97	PPSSDTSSKDHSGSE
S101	DTSSKDHSGSESPIS
S105	KDHSGSESPISDEEE
T137	QCNLCNKTYSTFSGL
K176	YVSLGALKMHIRTHT

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.