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Protein Page:
Snail2 (human)

Overview
Snail2 Transcriptional repressor. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle. Belongs to the snail C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Apoptosis; Motility/polarity/chemotaxis; Transcription factor
Cellular Component: nuclear chromatin; cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; metal ion binding; chromatin binding
Biological Process: Notch signaling pathway; substrate-bound cell migration, cell release from substrate; regulation of osteoblast differentiation; neural crest cell development; negative regulation of chondrocyte differentiation; palate development; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; osteoblast differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; embryonic development; sensory perception of sound; pigmentation; white fat cell differentiation; epithelial to mesenchymal transition; positive regulation of fat cell differentiation; positive regulation of histone acetylation; regulation of chemokine production; negative regulation of cell adhesion mediated by integrin; positive regulation of cell migration
Reference #:  O43623 (UniProtKB)
Alt. Names/Synonyms: MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; SLUG; slug (chicken homolog), zinc finger protein; SLUGH; SLUGH1; SNAI2; snail 2; snail homolog 2 (Drosophila); WS2D; Zinc finger protein SNAI2
Gene Symbols: SNAI2
Molecular weight: 29,986 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Snail2

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S92‑p, S96‑p, S100‑p
intracellular localization: S92‑p, S96‑p, S100‑p
protein degradation: S92‑p, S96‑p, S100‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S4 ____MPRSFLVKKHF
1 0 S54-p ILSSGAYsPITVWTT
2 0 S87-p SSSLGRVsPPPPsDT
1 0 S92-p RVsPPPPsDTSsKDH
1 0 S96-p PPPsDTSsKDHsGSE
1 0 S100-p DTSsKDHsGSEsPIS
2 0 S104-p KDHsGSEsPISDEEE
  mouse

 
S4-p ____MPRsFLVKKHF
S54 ILTSGAYSPITVWTS
S88-p SSSLGRVsPPPSSDT
S93 RVsPPPSSDTSSKDH
S97 PPSSDTSSKDHSGSE
S101 DTSSKDHSGSESPIS
S105 KDHSGSESPISDEEE
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