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Protein Page:
TRADD (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRADD Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP. Found in all examined tissues. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis
Cellular Component: cytoskeleton; cytoplasm; cytosol; nucleus; receptor complex; lipid raft
Molecular Function: identical protein binding; signal transducer activity; protein binding; protein complex binding; kinase binding; tumor necrosis factor receptor binding; molecular adaptor activity
Biological Process: caspase activation; positive regulation of hair follicle development; positive regulation of I-kappaB kinase/NF-kappaB cascade; induction of apoptosis via death domain receptors; tumor necrosis factor-mediated signaling pathway; apoptosis; positive regulation of apoptosis; protein heterooligomerization; signal transduction; activation of NF-kappaB transcription factor
Reference #:  Q15628 (UniProtKB)
Alt. Names/Synonyms: Hs.89862; MGC11078; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain; TRADD; tumor necrosis factor receptor type 1 associated death domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein
Gene Symbols: TRADD
Molecular weight: 34,247 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TRADD

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 A97 YREGALRAALQRSLA
0 1 Q143 LSCILAQQPDRLRDE
0 5 K163-ub EDALRNLkCGSGARG
1 0 S215-p PVVNRPLsLKDQQTF
1 0 S296-p LEENELTsLAEDLLG
  mouse

 
T97-p YREGALRtALQRCMA
K143-ub LNYILAQkPDRLRDE
T163 EDELCKLTCDCTGQG
T213 LVVNRPLTLQDQQTF
S294 LEENELTSLAEDLLG
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