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TRADD (human)

Overview TRADD Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP. Found in all examined tissues. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Apoptosis Cellular Component: cytoskeleton; cytoplasm; cytosol; nucleus; receptor complex Molecular Function: identical protein binding; protein binding; signal transducer activity; kinase binding; molecular adaptor activity Biological Process: caspase activation; positive regulation of hair follicle development; positive regulation of I-kappaB kinase/NF-kappaB cascade; tumor necrosis factor-mediated signaling pathway; apoptosis; induction of apoptosis; signal transduction Reference #:  Q15628 (UniProtKB) Alt. Names/Synonyms: Hs.89862; MGC11078; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain; TRADD; tumor necrosis factor receptor type 1 associated death domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein Gene Symbols: TRADD Molecular weight: 34,247 Da Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  SAPK/JNK Signaling Cascades  |  Signaling Pathways Activating p38 MAPK Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TRADD 1F2H - A=1-169 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		A97	YREGALRAALQRSLA
0	1		Q143	LSCILAQQPDRLRDE
0	5		K163-u	EDALRNLkCGSGARG
1	0		S215-p	PVVNRPLsLKDQQTF
1	0		S296-p	LEENELTsLAEDLLG

	mouse
T97-p	YREGALRtALQRCMA
K143-u	LNYILAQkPDRLRDE
T163	EDELCKLTCDCTGQG
T213	LVVNRPLTLQDQQTF
S294	LEENELTSLAEDLLG

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