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Protein Page:
TMC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TMC1 Required for the normal function of cochlear hair cells. Defects in TMC1 are the cause of deafness autosomal dominant type 36 (DFNA36). DFNA36 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA36 is a bilateral hearing loss, and begins at 5-10 years of age. It progresses to profound deafness within 10-15 years. Defects in TMC1 are the cause of deafness autosomal recessive type 7 (DFNB7); also known as autosomal recessive neurosensory deafness type 11 (DFNB11). This hearing loss is congenital and profound. Belongs to the TMC family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q21.12
Cellular Component: integral to membrane; stereocilium bundle tip; external side of plasma membrane
Molecular Function: voltage-gated calcium channel activity
Biological Process: vestibular reflex; auditory receptor cell development; detection of mechanical stimulus involved in sensory perception of sound
Disease: Deafness, Autosomal Recessive 7; Deafness, Autosomal Dominant 36
Reference #:  Q8TDI8 (UniProtKB)
Alt. Names/Synonyms: DFNA36; DFNB11; DFNB7; TMC1; transmembrane channel-like 1; Transmembrane channel-like protein 1; Transmembrane cochlear-expressed protein 1; transmembrane, cochlear expressed, 1
Gene Symbols: TMC1
Molecular weight: 87,768 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Select Structure to View Below

TMC1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T538 DVLTTYVTILIGDFL
0 1 K733-ub ANLDLKKkMKMQALE
  mouse

 
T535-p DVLTTYVtILIGDFL
K730 ANLDLKKKMKQQALE
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