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Protein Page:
RBBP5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RBBP5 As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with WDR5 and ASH2L; the interaction is direct. Interacts with WDR82 and SETD1A. Ubiquitously expressed. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: histone methyltransferase complex; nucleolus; nucleus
Molecular Function: protein binding; histone lysine N-methyltransferase activity (H3-K4 specific); methylated histone residue binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to estrogen stimulus; histone H3-K4 methylation; response to DNA damage stimulus
Reference #:  Q15291 (UniProtKB)
Alt. Names/Synonyms: RBBP-5; RBBP5; RBQ3; retinoblastoma binding protein 5; Retinoblastoma-binding protein 5; Retinoblastoma-binding protein RBQ-3; SWD1; SWD1, Set1c WD40 repeat protein, homolog
Gene Symbols: RBBP5
Molecular weight: 59,153 Da
Basal Isoelectric point: 4.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RBBP5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S8-p MNLELLEsFGQNyPE
0 1 Y13-p LEsFGQNyPEEADGt
0 1 T20-p yPEEADGtLDCISMA
0 1 K129-ub KVLVCPMksAPVMLT
0 1 S130-p VLVCPMksAPVMLTL
0 1 S182-p ILVLKTDsQDLVASF
0 1 T193-p VASFRVTtGTSNtTA
0 1 T198-p VTtGTSNtTAIKSIE
0 1 K209 KSIEFARKGSCFLIN
0 2 K244-ub GEPEPMQkLQDLVNR
0 1 T252-p LQDLVNRtPWKKCCF
0 1 K281-ac HALYIWEkSIGNLVK
0 5 S350-p VEYEEREsEFDIEDE
0 5 S388-p DPIAAFCssDEELED
0 6 S389-p PIAAFCssDEELEDS
0 2 S490 QAGRPKGSKGKEKDs
0 15 S497-p SKGKEKDsPFKPKLY
0 4 S515-p RGLPLEGsAKGKVQA
0 1 A516 GLPLEGsAKGKVQAE
0 12 S525-p GKVQAELsQPLTAGG
  RBBP5 iso2  
S8 MNLELLESFGQNYPE
Y13 LESFGQNYPEEADGT
T20 YPEEADGTLDCISMA
K129 KVLVCPMKSAPVMLT
S130 VLVCPMKSAPVMLTL
S182 ILVLKTDSQDLVASF
T193 VASFRVTTGTSNTTA
T198 VTTGTSNTTAIKSIE
K209 KSIEFARKGSCFLIN
K244 GEPEPMQKLQDLVNR
T252 LQDLVNRTPWKKCCF
K281 HALYIWEKSIGNLVK
S350 VEYEERESEFDIEDE
S388 DPIAAFCSSDEELED
S389 PIAAFCSSDEELEDS
S490-p QAGRPKGsKAGGAIS
- gap
- gap
- gap
- gap
  mouse

 
S8 MNLELLESFGQNYPE
Y13 LESFGQNYPEEADGT
T20 YPEEADGTLDCISMA
K129 KVLVCPMKSAPVMLT
S130 VLVCPMKSAPVMLTL
S182 ILVLKTDSQDLVASF
T193 VASFRVTTGTSNTTA
T198 VTTGTSNTTAIKSIE
K209-ac KSIEFARkGSCFLIN
K244-ub GEPEPMQkLQDLVNR
T252 LQDLVNRTPWKKCCF
K281 HALYIWEKSIGNLVK
S350-p VEYEEREsEFDIEDE
S388 DPIAAFCSSDEELED
S389 PIAAFCSSDEELEDS
S490 QAGRPKGSKGKEKDs
S497-p SKGKEKDsPFKPKLY
S515-p RGLPLEGstKGKVQA
T516-p GLPLEGstKGKVQAE
S525 GKVQAELSQSLAAGG
  rat

 
S8 MNLELLESFGQNYPE
Y13 LESFGQNYPEEADGT
T20 YPEEADGTLDCISMA
K129 KVLVCPMKSAPVMLT
S130 VLVCPMKSAPVMLTL
S182 ILVLKTDSQDLVASF
T193 VASFRVTTGTSNTTA
T198 VTTGTSNTTAIKSIE
K209 KSIEFARKGSCFLIN
K244 GEPEPMQKLQDLVNR
T252 LQDLVNRTPWKKCCF
K281 HALYIWEKSIGNLVK
S350 VEYEERESEFDIEDE
S388 DPIAAFCSSDEELED
S389 PIAAFCSSDEELEDS
S490 QAGRPKGSKGKEKDs
S497-p SKGKEKDsPFKPKLY
S515 RGLPLEGSTKGKVQA
T516 GLPLEGSTKGKVQAG
S525 GKVQAGLSQPLAAGG
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