a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of HSF1. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: protein complex; pronucleus; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; chromatin binding; transcription factor activity
Biological Process: negative regulation of cell proliferation; embryonic placenta development; transcription, DNA-dependent; embryonic process involved in female pregnancy; female meiosis; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; response to lipopolysaccharide; negative regulation of tumor necrosis factor production; positive regulation of multicellular organism growth; protein amino acid phosphorylation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.