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Protein Page:
K3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

K3 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K12. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: keratin filament; intermediate filament
Molecular Function: structural molecule activity
Biological Process: epithelial cell differentiation; intermediate filament cytoskeleton organization and biogenesis
Reference #:  P12035 (UniProtKB)
Alt. Names/Synonyms: 65 kDa cytokeratin; CK-3; CK3; cytokeratin 3; Cytokeratin-3; FLJ95909; K2C3; K3; keratin 3; Keratin, type II cytoskeletal 3; Keratin-3; KRT3; Type-II keratin Kb3
Gene Symbols: KRT3
Molecular weight: 64,417 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


1 29 K208-a QIkTLNNkFAsFIDk
0 8 K208-u QIkTLNNkFAsFIDk
0 16 S211-p TLNNkFAsFIDkVRF
0 6 K215-a kFAsFIDkVRFLEQQ
0 8 K215-u kFAsFIDkVRFLEQQ
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