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K3 (human)

Overview K3 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K12. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: keratin filament; intermediate filament Molecular Function: structural molecule activity Biological Process: epithelial cell differentiation; intermediate filament cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis Reference #:  P12035 (UniProtKB) Alt. Names/Synonyms: 65 kDa cytokeratin; CK-3; CK3; cytokeratin 3; Cytokeratin-3; FLJ95909; K2C3; K3; keratin 3; Keratin, type II cytoskeletal 3; Keratin-3; KRT3; Type-II keratin Kb3 Gene Symbols: KRT3 Molecular weight: 64,417 Da Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states

Select Structure to View Below K3

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 122100 148043  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		K203-u	AQEREQIkTLNNkFA
1	29		K208-a	QIkTLNNkFASFIDk
0	8		K208-u	QIkTLNNkFASFIDk
0	6		K215-a	kFASFIDkVRFLEQQ
0	8		K215-u	kFASFIDkVRFLEQQ
0	85		Y393-p	KAEAEALyQTKLGEL
0	1		Y502-p	LDVEIATyRKLLEGE
0	1		Y597-p	GSISGARyGVSGGGF

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