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Protein Page:
STEP (human)

Overview
STEP a non-receptor protein-tyrosine phosphatase. STEP (striatum enriched phosphatase) Contains a single phosphatase catalytic domain located at the C-terminus. Two alternatively-spliced messages have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: phosphotyrosine binding; protein tyrosine phosphatase activity
Biological Process: protein amino acid dephosphorylation
Reference #:  P54829 (UniProtKB)
Alt. Names/Synonyms: FLJ14427; Neural-specific protein-tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched); protein-tyrosine phosphatase striatum-enriched; PTN5; PTPN5; PTPSTEP; STEP; Striatum-enriched protein-tyrosine phosphatase; Tyrosine-protein phosphatase non-receptor type 5
Gene Symbols: PTPN5
Molecular weight: 63,538 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STEP

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, inhibited: S245‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S66-p PPPPSPPsDPAQKPP
0 2 S190 QSVSRQPSFTYSEWM
0 1 T192 VSRQPSFTYSEWMEE
0 1 Y193 SRQPSFTYSEWMEEK
6 0 S245-p GLQERRGsNVSLTLD
1 0 T255-p SLTLDMCtPGCNEEG
1 0 S268-p EGFGYLMsPREESAR
0 1 S444-p LRLISLKsGTEERGL
5659 : Nonphospho-STEP (Ser221) (D74H3) XP(R) Rabbit mAb
  mouse

 
S42 PPPPSPPSEPAQKLP
S166-p QSVSRQPsFtySEWM
T168-p VSRQPsFtySEWMEE
Y169-p SRQPsFtySEWMEEK
S221-p GLQERRGsNVSLTLD
T231 SLTLDMCTPGCNEEG
S244 EGFGYLVSPREESAH
R420 LRLISLRRGTEERSL
5659 : Nonphospho-STEP (Ser221) (D74H3) XP(R) Rabbit mAb
  rat

 
- gap
- gap
- gap
- gap
S49-p GLQERRGsNVSLTLD
T59 SLTLDMCTPGCNEEG
S72 EGFGYLVSPREESAH
R248 LRLISLRRGTEERGL
5659 : Nonphospho-STEP (Ser221) (D74H3) XP(R) Rabbit mAb
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