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STEP (human)

Overview STEP a non-receptor protein-tyrosine phosphatase. STEP (striatum enriched phosphatase) Contains a single phosphatase catalytic domain located at the C-terminus. Two alternatively-spliced messages have been described. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis Cellular Component: endoplasmic reticulum membrane; integral to membrane Molecular Function: phosphotyrosine binding; protein tyrosine phosphatase activity Biological Process: protein amino acid dephosphorylation Reference #:  P54829 (UniProtKB) Alt. Names/Synonyms: FLJ14427; Neural-specific protein-tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched); protein-tyrosine phosphatase striatum-enriched; PTN5; PTPN5; PTPSTEP; STEP; Striatum-enriched protein-tyrosine phosphatase; Tyrosine-protein phosphatase non-receptor type 5 Gene Symbols: PTPN5 Molecular weight: 63,538 Da Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STEP 2BIJ - A=256-539 (human) 2BV5 - A=256-537 (human) 2CJZ - A=256-539 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2BIJ 2BV5 2CJZ  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature A001944 A001945 A001946  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, inhibited: S245‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S66-p	PPPPSPPsDPAQKPP
0	2		S190	QSVSRQPSFTYSEWM
0	1		T192	VSRQPSFTYSEWMEE
0	1		Y193	SRQPSFTYSEWMEEK
5	0		S245-p	GLQERRGsNVSLTLD
1	0		T255-p	SLTLDMCtPGCNEEG
1	0		S268-p	EGFGYLMsPREESAR
0	1		S444-p	LRLISLKsGTEERGL

	mouse
S42	PPPPSPPSEPAQKLP
S166-p	QSVSRQPsFtySEWM
T168-p	VSRQPsFtySEWMEE
Y169-p	SRQPsFtySEWMEEK
S221-p	GLQERRGsNVSLTLD
T231	SLTLDMCTPGCNEEG
S244	EGFGYLVSPREESAH
R420	LRLISLRRGTEERSL

	rat
-	gap
-	gap
-	gap
-	gap
S49-p	GLQERRGsNVSLTLD
T59	SLTLDMCTPGCNEEG
S72	EGFGYLVSPREESAH
R248	LRLISLRRGTEERGL

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