Home

AP1M1 (human)

Overview AP1M1 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes medium subunit family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Vesicle protein Cellular Component: Golgi membrane; cytoplasmic vesicle membrane; clathrin adaptor complex; lysosomal membrane; clathrin coated vesicle membrane; trans-Golgi network membrane; cytosol Molecular Function: protein binding Biological Process: intracellular protein transport; viral reproduction; melanosome organization and biogenesis; virus-host interaction; antigen processing and presentation of exogenous peptide antigen via MHC class II; post-Golgi vesicle-mediated transport; regulation of defense response to virus by virus; membrane organization and biogenesis Reference #:  Q9BXS5 (UniProtKB) Alt. Names/Synonyms: Adaptor protein complex AP-1 mu-1 subunit; Adaptor-related protein complex 1 mu-1 subunit; adaptor-related protein complex 1, mu 1 subunit; AP-1 complex subunit mu-1; AP-mu chain family member mu1A; AP1M1; AP47; CLAPM2; clathrin adaptor protein AP47; Clathrin assembly protein complex 1 medium chain 1; clathrin assembly protein complex 1, medium chain; clathrin assembly protein complex AP1, mu subunit; Clathrin coat assembly protein AP47; Clathrin coat-associated protein AP47; CLTNM; golgi adaptor AP-1 47 kDa protein; Golgi adaptor HA1/AP1 adaptin mu-1 subunit; HA1 47 kDa subunit; MU-1A; Mu-adaptin 1; Mu1A-adaptin Gene Symbols: AP1M1 Molecular weight: 48,587 Da Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states

Select Structure to View Below AP1M1 1W63 - M/N/O/P/R/V=1-423 (mouse) 4EMZ - A/M=158-423 (mouse) 4EN2 - A/M=158-423 (mouse) 4HMY - C=17-181 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y134-p	DSKILQEyITQEGHK
0	3		T144-p	QEGHKLEtGAPRPPA
0	16		T152-p	GAPRPPAtVtNAVsW
0	11		T154-p	PRPPAtVtNAVsWRS
0	2		S158-p	AtVtNAVsWRSEGIK
0	1		K165	sWRSEGIKYRKNEVF
0	1		K217-u	LRLGLNDkVLFDNtG
0	15		T223-p	DkVLFDNtGRGKSKS
0	1		S299-p	EYMIKAKsQFKRRsT
0	1		S305-p	KsQFKRRsTANNVEI
0	1		S322-p	PVPNDADsPKFkTTV
0	2		K326-u	DADsPKFkTTVGSVK
0	1		K346-u	SEIVWSIkSFPGGKE
0	3		K400-u	RYLKIIEkSGYQALP

	mouse
Y134	DSKILQEYITQEGHK
T144-p	QEGHKLEtGAPRPPA
T152-p	GAPRPPAtVtNAVSW
T154-p	PRPPAtVtNAVSWRS
S158	AtVtNAVSWRSEGIk
K165-a	SWRSEGIkYRKNEVF
K217	LRLGLNDKVLFDNtG
T223-p	DKVLFDNtGRGKSKS
S299	EYMVKAKSQFKRRST
S305	KSQFKRRSTANNVEI
S322	PVPNDADSPKFkTTV
K326-u	DADSPKFkTTVGSVK
K346	SEIVWSVKSFPGGKE
K400-u	RYLKIIEkSGYQALP

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.