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Protein Page:
AP1M1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AP1M1 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes medium subunit family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Cellular Component: Golgi membrane; clathrin adaptor complex; cytoplasmic vesicle membrane; lysosomal membrane; clathrin coated vesicle membrane; trans-Golgi network membrane; cytosol
Molecular Function: protein binding
Biological Process: intracellular protein transport; viral reproduction; melanosome organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; post-Golgi vesicle-mediated transport; regulation of defense response to virus by virus
Reference #:  Q9BXS5 (UniProtKB)
Alt. Names/Synonyms: Adaptor protein complex AP-1 mu-1 subunit; Adaptor-related protein complex 1 mu-1 subunit; adaptor-related protein complex 1, mu 1 subunit; AP-1 complex subunit mu-1; AP-mu chain family member mu1A; AP1M1; AP47; CLAPM2; clathrin adaptor protein AP47; Clathrin assembly protein complex 1 medium chain 1; clathrin assembly protein complex 1, medium chain; clathrin assembly protein complex AP1, mu subunit; Clathrin coat assembly protein AP47; Clathrin coat-associated protein AP47; CLTNM; golgi adaptor AP-1 47 kDa protein; Golgi adaptor HA1/AP1 adaptin mu-1 subunit; HA1 47 kDa subunit; MU-1A; Mu-adaptin 1; Mu1A-adaptin
Gene Symbols: AP1M1
Molecular weight: 48,587 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
Select Structure to View Below

AP1M1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K12 AVYVLDLKGKVLICR
0 1 K12 AVYVLDLKGKVLICR
0 1 Y134-p DSKILQEyITQEGHK
0 3 T144-p QEGHKLEtGAPRPPA
0 20 T152-p GAPRPPAtVtNAVsW
0 17 T154-p PRPPAtVtNAVsWRS
0 2 S158-p AtVtNAVsWRSEGIK
0 1 K165 sWRSEGIKYRKNEVF
0 1 K217-ub LRLGLNDkVLFDNtG
0 16 T223-p DkVLFDNtGRGKSKS
0 1 S299-p EYMIKAKsQFKRRsT
0 1 S305-p KsQFKRRsTANNVEI
0 1 S322-p PVPNDADsPKFkTTV
0 1 K324 PNDADsPKFkTTVGS
0 2 K326-ub DADsPKFkTTVGSVK
0 1 K346-ub SEIVWSIkSFPGGKE
0 3 K400-ub RYLKIIEkSGYQALP
  mouse

 
K12-ac AVYVLDLkGKVLICR
K12-sc AVYVLDLkGKVLICR
Y134 DSKILQEYITQEGHK
T144-p QEGHKLEtGAPRPPA
T152-p GAPRPPAtVtNAVSW
T154-p PRPPAtVtNAVSWRS
S158 AtVtNAVSWRSEGIk
K165-ac SWRSEGIkYRKNEVF
K217 LRLGLNDKVLFDNtG
T223-p DKVLFDNtGRGKSKS
S299 EYMVKAKSQFKRRST
S305 KSQFKRRSTANNVEI
S322 PVPNDADSPkFkTTV
K324-ac PNDADSPkFkTTVGS
K326-ub DADSPkFkTTVGSVK
K346 SEIVWSVKSFPGGKE
K400-ub RYLKIIEkSGYQALP
  rat

 
K12 AVYVLDLKGKVLICR
K12 AVYVLDLKGKVLICR
Y134 DSKILQEYITQEGHK
T144 QEGHKLETGAPRPPA
T152 GAPRPPATVTNAVSW
T154 PRPPATVTNAVSWRS
S158 ATVTNAVSWRSEGIK
K165 SWRSEGIKYRKNEVF
K217 LRLGLNDKVLFDNTG
T223 DKVLFDNTGRGKSKS
S299 EYMVKAKSQFKRRST
S305 KSQFKRRSTANNVEI
S322 PVPNDADSPKFKTTV
K324 PNDADSPKFKTTVGS
K326 DADSPKFKTTVGSVK
K346 SEIVWSIKSFPGGKE
K400 RYLKIIEKSGYQALP
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