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POLRMT (human)

Overview POLRMT DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. Note: This description may include information from UniProtKB. Protein type: EC 2.7.7.6; Mitochondrial; Transferase; Transcription initiation complex Cellular Component: mitochondrion; mitochondrial matrix Molecular Function: protein binding; DNA binding; DNA-directed RNA polymerase activity Biological Process: gene expression; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter Reference #:  O00411 (UniProtKB) Alt. Names/Synonyms: APOLMT; DNA-directed RNA polymerase, mitochondrial; h-mtRPOL; MTRNAP; MtRPOL; POLRMT; polymerase (RNA) mitochondrial (DNA directed); RPOM Gene Symbols: POLRMT Molecular weight: 138,620 Da Basal Isoelectric point: 9.19  Predict pI for various phosphorylation states

Select Structure to View Below POLRMT 3SPA - A=105-1230 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S77-p	VRQLQAEsVSEVVVN
0	1		Y299-p	LTPDLLSyAAALQCM
0	2		T315-p	RQDQDAGtIERCLEQ
0	1		Y386-p	AKDGRVSyPKLHLPL
0	1		K402-a	TLQCLFEkQLHMELA
0	1		T993-p	TRKVVKQtVMTVVyG
0	3		Y999-p	QtVMTVVyGVTRyGG
0	1		Y1004-p	VVyGVTRyGGRLQIE
0	1		Y1082	GVPVIQPYRLDSKVK
0	1		K1197-u	RFCSEPQkILEASQL

	mouse
G75	VRQLRAEGTPEMRVK
Y271	LSPDLCSYAAALQCM
T287	RRDQDVRTIQRCLKQ
Y358	SKEGPVSYPKLHLPL
Q374	TLQDLFYQQLHVELS
T964	SRKVVKQTVMTVVYG
Y970	QTVMTVVYGVTRYGG
Y975	VVYGVTRYGGRLQIE
Y1053-p	GIPIIQPyHRESKVQ
-	under review

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