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Protein Page:
GABBR1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GABBR1 Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1. Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: presynaptic membrane; postsynaptic membrane; integral to plasma membrane; dendrite; cytoplasm; extracellular region; plasma membrane; cell junction
Molecular Function: protein binding; GABA-B receptor activity
Biological Process: synaptic transmission; negative regulation of adenylate cyclase activity; G-protein signaling, adenylate cyclase inhibiting pathway; gamma-aminobutyric acid signaling pathway
Reference #:  Q9UBS5 (UniProtKB)
Alt. Names/Synonyms: dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABAB, subunit 1c; GABABR1; GABBR1; GABBR1-3; GABR1; gamma-aminobutyric acid (GABA) B receptor 1; gamma-aminobutyric acid (GABA) B receptor, 1; Gamma-aminobutyric acid type B receptor subunit 1; Gb1; GPRC3A
Gene Symbols: GABBR1
Molecular weight: 108,320 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GABBR1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y209-p RRDILPDyELKLIHH
0 1 S247 IILMPGCSSVSTLVA
0 1 S248 ILMPGCSSVSTLVAE
0 1 S250 MPGCSSVSTLVAEAA
0 4 Y776-p WLGIFYGyKGLLLLL
1 0 S868 ITRGEWQSEAQDTMK
0 5 T873 WQSEAQDTMKTGSST
0 1 S878 QDTMKTGSSTNNNEE
0 3 K893 EKSRLLEKENRELEK
1 0 S918 ELRHQLQSRQQLRSR
0 9 T930-p RSRRHPPtPPEPSGG
0 1 S935 PPtPPEPSGGLPRGP
0 3 S950 PEPPDRLSCDGSRVH
  mouse

 
Y208 RRDILPDYELKLIHH
S246-p IILMPGCssVsTLVA
S247-p ILMPGCssVsTLVAE
S249-p MPGCssVsTLVAEAA
Y775-p WLGIFYGyKGLLLLL
S867-p ITRGEWQsEAQDtMK
T872-p WQsEAQDtMKTGsST
S877-p QDtMKTGsSTNNNEE
K892-u EKSRLLEkENRELEK
S917 ELRHQLQSRQQIRSR
T929-p RSRRHPPtPPDPsGG
S934-p PPtPPDPsGGLPRGP
S949-p SEPPDRLsCDGSRVH
  rat

 
Y208 RRDILPDYELKLIHH
S246 IILMPGCSSVSTLVA
S247 ILMPGCSSVSTLVAE
S249 MPGCSSVSTLVAEAA
Y806 PESIFYGYKGLLLLL
S898 ITRGEWQSETQDTMK
T903 WQSETQDTMKTGSST
S908 QDTMKTGSSTNNNEE
K923-u EKSRLLEkENRELEK
S948-p ELRHQLQsRQQLRSR
T960 RSRRHPPTPPDPSGG
S965 PPTPPDPSGGLPRGP
S980 SEPPDRLSCDGSRVH
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