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Protein Page:
HK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HK2 a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). The predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase). Genetic variations of HK2 do not appear to contribute to NIDDM. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Kinase, other; Carbohydrate Metabolism - galactose; EC 2.7.1.1; Mitochondrial
Cellular Component: mitochondrial outer membrane; membrane; cytosol
Molecular Function: hexokinase activity; mannokinase activity; fructokinase activity; glucokinase activity; ATP binding; glucose binding
Biological Process: lactation; apoptotic mitochondrial changes; glycolysis; hexose transport; carbohydrate metabolic process; carbohydrate phosphorylation; glucose 6-phosphate metabolic process; glucose metabolic process; cell glucose homeostasis; regulation of glucose import; glucose transport; transmembrane transport
Reference #:  P52789 (UniProtKB)
Alt. Names/Synonyms: DKFZp686M1669; hexokinase 2; Hexokinase type II; Hexokinase-2; hexokinase-2, muscle; HK II; HK2; HKII; HXK2; Muscle form hexokinase
Gene Symbols: HK2
Molecular weight: 102,380 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y9-p IASHLLAyFFTELNH
0 3 K41-ub ETLLEISkRFRKEME
0 1 K62-ub THPTAAVkMLPTFVR
0 2 K104-ub VTDNGLQkVEMENQI
0 4 Y112-p VEMENQIyAIPEDIM
0 1 T153-p KKLPLGFtFSFPCHQ
0 5 K173-ub SFLVSWTkGFKSSGV
0 2 K290-ub MGSLNPGkQLFEKMI
0 11 Y301-p EKMISGMyMGELVRL
0 1 K315-ub LILVKMAkEELLFGG
0 20 K323-ub EELLFGGkLSPELLN
0 3 K337-ub NTGRFETkDIsDIEG
0 1 S340-p RFETkDIsDIEGEkD
0 3 K346-ub IsDIEGEkDGIRKAR
0 1 S384-p IVSTRSAsLCAATLA
0 1 K418-ub GVDGSVYkKHPHFAK
0 1 S445-p CDVRFLRsEDGsGkG
0 1 S449-p FLRsEDGsGkGAAMV
0 2 K451-ub RsEDGsGkGAAMVTA
0 115 Y461-p AMVTAVAyRLADQHR
2 0 T473 QHRARQKTLEHLQLS
0 3 K488-ub HDQLLEVkRRMKVEM
0 1 S506-p LSKETHAsAPVKMLP
0 1 T514-p APVKMLPtYVCATPD
0 1 K525-ub ATPDGTEkGDFLALD
0 2 K738-ub ELSLNPGkQRFEKMI
0 1 S746-p QRFEKMIsGMyLGEI
0 10 Y749-p EKMIsGMyLGEIVRN
0 1 T762-p RNILIDFtKRGLLFR
0 1 K763 NILIDFtKRGLLFRG
0 1 K866-ub GVDGTLYkLHPHFAK
0 2 K885-ub TVKDLAPkCDVSFLQ
0 1 S897-p FLQSEDGsGkGAALI
0 7 K899-ub QSEDGsGkGAALItA
0 1 T905-p GkGAALItAVACRIR
  mouse

 
C9 IASHMIACLFTELNQ
R41 ETLLEISRRFRKEME
K62 THPTAAVKMLPTFVR
R104 VTDNGLQRVEMENQI
Y112 VEMENQIYAIPEDIM
T153 KKLPLGFTFSFPCHQ
K173 SFLVSWTKGFKSSGV
K290 MGSLNPGKQLFEKMI
Y301 EKMISGMYMGELVRL
K315 LILVKMAKAELLFQG
K323 AELLFQGKLSPELLT
K337 TTGSFETKDVSDIED
S340 SFETKDVSDIEDDKD
K346 VSDIEDDKDGIQKAY
S384 IVSTRSASLCAATLA
K418 GVDGSVYKKHPHFAK
S445 CDVRFLRSEDGSGkG
S449 FLRSEDGSGkGAAMV
K451-ub RSEDGSGkGAAMVTA
Y461-p AMVTAVAyRLADQHR
T473-p QHRARQKtLESLKLS
K488-ub HEQLLEVkRRMKVEM
A506 LSKETHEAAPVKMLP
T514 APVKMLPTYVCATPD
K525 ATPDGTEKGDFLALD
K738-ub ELSLNPGkQRFEKMI
S746 QRFEKMISGMYLGEI
Y749 EKMISGMYLGEIVRN
T762 RNILIDFTkRGLLFR
K763-ub NILIDFTkRGLLFRG
K866 GVDGTLYKLHPHFAK
K885-ub TVRDLAPkCDVSFLE
S897 FLESEDGSGkGAALI
K899-ub ESEDGSGkGAALITA
T905 GkGAALITAVACRIR
  rat

 
C9 IASHMIACLFTELNQ
R41 ETLLEISRRFRKEME
K62 THPTAAVKMLPTFVR
R104 VTDNGLQRVEMENQI
Y112 VEMENQIYAIPEDIM
T153 KKLPLGFTFSFPCHQ
K173 SFLVSWTKGFKSSGV
K290 MGSLNPGKQLFEKMI
Y301 EKMISGMYMGELVRL
K315 LILVKMAKAELLFQG
K323 AELLFQGKLSPELLT
K337 TTGSFETKDVSDIEE
S340 SFETKDVSDIEEDKD
K346 VSDIEEDKDGIEKAY
S384 IVSTRSASLCAATLA
K418 GVDGSVYKKHPHFAK
S445 CDVRFLRSEDGSGKG
S449 FLRSEDGSGKGAAMV
K451 RSEDGSGKGAAMVTA
Y461-p AMVTAVAyRLADQHR
T473 QHRARQKTLESLKLS
K488 HEQLLEVKRRMKVEM
V506 LSKETHAVAPVKMLP
T514 APVKMLPTYVCATPD
K525 ATPDGTEKGDFLALD
K738 ELSLNPGKQRFEKMI
S746 QRFEKMISGMyLGEI
Y749-p EKMISGMyLGEIVRN
T762 RNILIDFTKRGLLFR
K763 NILIDFTKRGLLFRG
K866 GVDGTLYKLHPHFAK
K885 TVRDLAPKCDVSFLE
S897 FLESEDGSGKGAALI
K899 ESEDGSGKGAALITA
T905 GKGAALITAVACRIR
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