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HK2
a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). The predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase). Genetic variations of HK2 do not appear to contribute to NIDDM. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.1.1; Mitochondrial; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - fructose and mannose; Kinase, other; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - amino sugar and nucleotide sugar |
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Cellular Component: mitochondrial outer membrane; cytosol
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Molecular Function: hexokinase activity; ATP binding; glucose binding
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Biological Process: lactation; apoptotic mitochondrial changes; glycolysis; hexose transport; carbohydrate metabolic process; regulation of glucose import; glucose transport; transmembrane transport
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Reference #:
P52789 (UniProtKB)
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| Alt. Names/Synonyms: DKFZp686M1669; hexokinase 2; Hexokinase type II; Hexokinase-2; hexokinase-2, muscle; HK II; HK2; HKII; HXK2; Muscle form hexokinase |
| Gene Symbols: HK2 |
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Molecular weight: 102,380 Da
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Basal Isoelectric point: 5.71
Predict pI for various phosphorylation states
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CST Pathways:
Warburg Effect
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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