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Protein Page:
SFRP1 (human)

Overview
SFRP1 Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription. Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8. Down-regulated in colorectal and breast tumors. Up- regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions. Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. Belongs to the secreted frizzled-related protein (sFRP) family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; cell surface; cell projection; plasma membrane; intracellular; cytosol
Molecular Function: heparin binding; identical protein binding; Wnt-protein binding; Wnt receptor activity; protein binding; frizzled binding; cysteine-type endopeptidase activity; drug binding; PDZ domain binding
Biological Process: negative regulation of Wnt receptor signaling pathway; somatic stem cell maintenance; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin; proteolysis; response to organic cyclic substance; negative regulation of insulin secretion; negative regulation of BMP signaling pathway; positive regulation of stress fiber formation; negative regulation of ossification; positive regulation of smoothened signaling pathway; negative regulation of osteoblast differentiation; female gonad development; response to drug; negative regulation of peptidyl-tyrosine phosphorylation; menstrual cycle phase; digestive tract morphogenesis; cellular response to starvation; positive regulation of cell growth; negative regulation of fibroblast proliferation; negative regulation of bone remodeling; positive regulation of fat cell differentiation; negative regulation of osteoblast proliferation; neural crest cell fate commitment; hemopoietic progenitor cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of osteoclast differentiation; gonad development; dorsal/ventral axis specification; negative regulation of cell proliferation; vasculature development; positive regulation of focal adhesion formation; ureteric bud development; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; negative regulation of cell migration; positive regulation of Wnt receptor signaling pathway; negative regulation of epithelial cell proliferation; negative regulation of B cell differentiation; negative regulation of JNK activity; male gonad development; regulation of angiogenesis; osteoblast differentiation; embryonic development; neural tube closure; positive regulation of Rac GTPase activity; brain development; negative regulation of cell growth
Reference #:  Q8N474 (UniProtKB)
Alt. Names/Synonyms: FRP; FRP-1; FRP1; FrzA; SARP-2; SARP2; Secreted apoptosis-related protein 2; Secreted frizzled-related protein 1; sFRP-1; SFRP1
Gene Symbols: SFRP1
Molecular weight: 35,386 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
CST Pathways:  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SFRP1

Protein Structure Not Found.


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