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Protein Page:
SFRP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SFRP1 Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription. Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8. Down-regulated in colorectal and breast tumors. Up- regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions. Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. Belongs to the secreted frizzled-related protein (sFRP) family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; cell projection; cell surface; plasma membrane; intracellular; cytosol
Molecular Function: heparin binding; identical protein binding; Wnt-protein binding; Wnt receptor activity; protein binding; frizzled binding; cysteine-type endopeptidase activity; drug binding; PDZ domain binding
Biological Process: negative regulation of osteoclast differentiation; negative regulation of Wnt receptor signaling pathway; gonad development; positive regulation of apoptosis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; dorsal/ventral axis specification; Wnt receptor signaling pathway through beta-catenin; proteolysis; response to organic cyclic substance; negative regulation of BMP signaling pathway; negative regulation of insulin secretion; negative regulation of cell proliferation; positive regulation of focal adhesion formation; vasculature development; ureteric bud development; positive regulation of stress fiber formation; positive regulation of cell proliferation; negative regulation of ossification; positive regulation of smoothened signaling pathway; negative regulation of osteoblast differentiation; positive regulation of cell-matrix adhesion; negative regulation of cell migration; positive regulation of Wnt receptor signaling pathway; female gonad development; negative regulation of epithelial cell proliferation; response to drug; negative regulation of B cell differentiation; negative regulation of JNK activity; negative regulation of peptidyl-tyrosine phosphorylation; menstrual cycle phase; male gonad development; digestive tract morphogenesis; cellular response to starvation; regulation of angiogenesis; positive regulation of cell growth; osteoblast differentiation; negative regulation of fibroblast proliferation; negative regulation of bone remodeling; neural tube closure; positive regulation of fat cell differentiation; positive regulation of Rac GTPase activity; hemopoietic progenitor cell differentiation; neural crest cell fate commitment; negative regulation of osteoblast proliferation; brain development; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; negative regulation of apoptosis
Reference #:  Q8N474 (UniProtKB)
Alt. Names/Synonyms: FRP; FRP-1; FRP1; FrzA; SARP-2; SARP2; Secreted apoptosis-related protein 2; Secreted frizzled-related protein 1; sFRP-1; SFRP1
Gene Symbols: SFRP1
Molecular weight: 35,386 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
CST Pathways:  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SFRP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 P45 SFQSDIGPYQSGRFY
0 1 K223-ac VKKENGDkkIVPKKK
0 1 K224-ac KKENGDkkIVPKKKk
0 1 K231-ac kIVPKKKkPLKLGPI
0 1 K239-ac PLKLGPIkKKDLKKL
  mouse

 
S45-p SFQSDIGsYQSGRFY
K223 VKKENGDKKIVPKKK
K224 KKENGDKKIVPKKKK
K231 KIVPKKKKPLKLGPI
K239 PLKLGPIKKKELKRL
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