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Protein Page:
ATP1A3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATP1A3 This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Defects in ATP1A3 are the cause of dystonia type 12 (DYT12); also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant dystonia- parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT12 patients develop dystonia and parkinsonism between 15 and 45 years of age. The disease is characterized by an unusually rapid evolution of signs and symptoms. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Transporter; Transporter, ion channel; EC 3.6.3.9; Hydrolase; Membrane protein, multi-pass
Cellular Component: Golgi apparatus; axon; endoplasmic reticulum; plasma membrane; integral to membrane; synapse; nucleus; sodium:potassium-exchanging ATPase complex; myelin sheath
Molecular Function: metal ion binding; sodium:potassium-exchanging ATPase activity; D1 dopamine receptor binding; ATP binding
Biological Process: response to drug; adult locomotory behavior; ionotropic glutamate receptor signaling pathway; ATP biosynthetic process; visual learning; transmembrane transport; memory; potassium ion transport
Reference #:  P13637 (UniProtKB)
Alt. Names/Synonyms: AT1A3; ATP1A3; ATPase, Na+/K+ transporting, alpha 3 polypeptide; DYT12; MGC13276; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+/K+ ATPase 3; RDP; sodium pump 3; Sodium pump subunit alpha-3; sodium-potassium-ATPase, alpha 3 polypeptide; sodium/potassium-transporting ATPase alpha-3 chain; Sodium/potassium-transporting ATPase subunit alpha-3
Gene Symbols: ATP1A3
Molecular weight: 111,749 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Select Structure to View Below

ATP1A3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 D9 GDKKDDKDSPKKNKG
0 1 S10 DKKDDKDSPKKNKGK
0 5 K26 RRDLDDLKKEVAMTE
0 4 K27 RDLDDLKKEVAMTEH
0 1 K35 EVAMTEHKMSVEEVC
0 3 S37 AMTEHKMSVEEVCRK
0 2 K44 SVEEVCRKYNTDCVQ
0 13 Y45 VEEVCRKYNTDCVQG
0 3 S56 CVQGLTHSKAQEILA
0 16 K57 VQGLTHSKAQEILAR
0 2 T71-p RDGPNALtPPPTTPE
0 2 K146-ub YQEAKSSkIMESFkN
0 22 K152-ub SkIMESFkNMVPQQA
0 2 K167 LVIREGEKMQVNAEE
0 2 K184 VGDLVEIKGGDRVPA
0 2 S197 PADLRIISAHGCKVD
0 6 K202 IISAHGCKVDNSsLT
0 10 S207-p GCKVDNSsLTGEsEP
0 1 T209 KVDNSsLTGEsEPQt
0 7 S212-p NSsLTGEsEPQtRSP
0 3 T216-p TGEsEPQtRSPDCTH
0 3 S218 EsEPQtRSPDCTHDN
0 1 T237 RNITFFSTNCVEGTA
0 1 T255 VVATGDRTVMGRIAT
0 1 T262 TVMGRIATLASGLEV
0 1 S265 GRIATLASGLEVGKT
0 2 K349-ub ARKNCLVkNLEAVET
0 1 K367 TSTICSDKtGTLTQN
0 6 K367-ub TSTICSDktGTLTQN
0 2 T368-p STICSDktGTLTQNR
0 6 K424 LCNRAVFKGGQDNIP
0 6 K434 QDNIPVLKRDVAGDA
0 12 K434 QDNIPVLKRDVAGDA
0 4 S442 RDVAGDASESALLKC
0 1 S444 VAGDASESALLKCIE
0 1 K448 ASESALLKCIELSSG
0 1 S453 LLKCIELSSGSVKLM
0 1 S454 LKCIELSSGSVKLMR
0 3 S456 CIELSSGSVKLMRER
0 1 K458 ELSSGSVKLMRERNK
0 21 K458 ELSSGSVKLMRERNK
0 1 K466-ac LMRERNKkVAEIPFN
0 3 S474 VAEIPFNSTNKyQLs
0 1 K477 IPFNSTNKyQLsIHE
0 1 Y478-p PFNSTNKyQLsIHEt
0 1 S481-p STNKyQLsIHEtEDP
0 1 T485-p yQLsIHEtEDPNDNR
0 1 Y493 EDPNDNRYLLVMKGA
0 1 K498 NRYLLVMKGAPERIL
0 2 K516 STILLQGKEQPLDEE
0 1 K525 QPLDEEMKEAFQNAY
0 4 Y532 KEAFQNAYLELGGLG
0 36 Y548-p RVLGFCHyyLPEEQF
0 28 Y549-p VLGFCHyyLPEEQFP
0 64 K595-ub AVPDAVGkCRSAGIK
0 3 T607-p GIKVIMVtGDHPITA
0 3 K615-ub GDHPITAkAIAkGVG
0 4 K619-ub ITAkAIAkGVGIISE
0 2 S625 AkGVGIISEGNETVE
0 4 T630 IISEGNETVEDIAAR
0 14 S643-p ARLNIPVsQVNPRDA
0 7 K651 QVNPRDAKACVIHGT
0 1 T658 KACVIHGTDLKDFTS
0 3 K661 VIHGTDLKDFTSEQI
0 2 K688-ub ARTSPQQkLIIVEGC
0 5 S712-p TGDGVNDsPALkkAD
0 3 K716 VNDsPALKkADIGVA
1 1 K716 VNDsPALKkADIGVA
0 5 K716-ub VNDsPALkkADIGVA
0 1 K717 NDsPALkKADIGVAM
1 1 K717 NDsPALkKADIGVAM
0 7 K717-ub NDsPALkkADIGVAM
1 1 K763 RLIFDNLKKSIAYTL
0 2 K763-ub RLIFDNLkKSIAYTL
1 1 K764 LIFDNLkKSIAYTLT
0 1 K823-ub AAESDIMkRQPRNPR
0 1 T831 RQPRNPRTDkLVNER
0 7 K833-ub PRNPRTDkLVNERLI
0 1 S933-p ICKTRRNsVFQQGMk
0 5 K940-ub sVFQQGMkNKILIFG
0 1 K1009 NPGGWVEKEtYY___
0 2 T1011-p GGWVEKEtYY_____
0 21 Y1012 GWVEKEtYY______
0 14 Y1013 WVEKEtYY_______
  mouse

 
S9-p GDKKDDKssPKKSKA
S10-p DKKDDKssPKKSKAK
K26 RRDLDDLKkEVAMTE
K27-ub RDLDDLKkEVAMTEH
K35-ub EVAMTEHkMsVEEVC
S37-p AMTEHkMsVEEVCRk
K44-ub sVEEVCRkYNTDCVQ
Y45 VEEVCRkYNTDCVQG
S56-p CVQGLTHskAQEILA
K57-ub VQGLTHskAQEILAR
T71-p RDGPNALtPPPTTPE
K146-ub YQEAKSSkIMESFkN
K152-ub SkIMESFkNMVPQQA
K167-ub LVIREGEkMQVNAEE
K184-ub VGDLVEIkGGDRVPA
S197-p PADLRIIsAHGCkVD
K202-ub IIsAHGCkVDNSsLt
S207-p GCkVDNSsLtGEsEP
T209-p kVDNSsLtGEsEPQt
S212-p NSsLtGEsEPQtRsP
T216-p tGEsEPQtRsPDCTH
S218-p EsEPQtRsPDCTHDN
T237-p RNITFFStNCVEGTA
T255-p VVATGDRtVMGRIAt
T262-p tVMGRIAtLAsGLEV
S265-p GRIAtLAsGLEVGKT
K349-ub ARKNCLVkNLEAVET
K367-ac TSTICSDktGTLTQN
K367-ub TSTICSDktGTLTQN
T368-p STICSDktGTLTQNR
K424-ub LCNRAVFkGGQDNIP
K434-ac QDNIPVLkRDVAGDA
K434-ub QDNIPVLkRDVAGDA
S442-p RDVAGDAsEsALLkC
S444-p VAGDAsEsALLkCIE
K448-ub AsEsALLkCIELssG
S453-p LLkCIELssGsVkLM
S454-p LkCIELssGsVkLMR
S456-p CIELssGsVkLMRER
K458-ac ELssGsVkLMRERNK
K458-ub ELssGsVkLMRERNK
K466 LMRERNKKVAEIPFN
S474-p VAEIPFNsTNkYQLS
K477-ub IPFNsTNkYQLSIHE
Y478 PFNsTNkYQLSIHET
S481 sTNkYQLSIHETEDP
T485 YQLSIHETEDPNDNR
Y493-p EDPNDNRyLLVMkGA
K498-ub NRyLLVMkGAPERIL
K516-ub ATILLQGkEQPLDEE
K525-ub QPLDEEMkEAFQNAy
Y532-p kEAFQNAyLELGGLG
Y548-p RVLGFCHyyLPEEQF
Y549-p VLGFCHyyLPEEQFP
K595-ub AVPDAVGkCRSAGIK
T607-p GIKVIMVtGDHPITA
K615-ub GDHPITAkAIAkGVG
K619-ub ITAkAIAkGVGIIsE
S625-p AkGVGIIsEGNEtVE
T630-p IIsEGNEtVEDIAAR
S643-p ARLNIPVsQVNPRDA
K651-ub QVNPRDAkACVIHGt
T658-p kACVIHGtDLkDFTS
K661-ub VIHGtDLkDFTSEQI
K688-ub ARTSPQQkLIIVEGC
S712-p TGDGVNDsPALkkAD
K716-ac VNDsPALkkADIGVA
K716 VNDsPALKkADIGVA
K716-ub VNDsPALkkADIGVA
K717 NDsPALkKADIGVAM
K717 NDsPALkKADIGVAM
K717-ub NDsPALkkADIGVAM
K763 RLIFDNLKKSIAYTL
K763-ub RLIFDNLkKSIAYTL
K764 LIFDNLkKSIAYTLT
K823 AAESDIMKRQPRNPR
T831-p RQPRNPRtDkLVNER
K833-ub PRNPRtDkLVNERLI
S933-p ICKTRRNsVFQQGMk
K940-ub sVFQQGMkNKILIFG
K1009-ub NPGGWVEkETyy___
T1011 GGWVEkETyy_____
Y1012-p GWVEkETyy______
Y1013-p WVEkETyy_______
  rat

 
S9 GDKKDDKSSPKKSKA
S10 DKKDDKSSPKKSKAK
K26-ub RRDLDDLkkEVAMTE
K27-ub RDLDDLkkEVAMTEH
K35 EVAMTEHKMsVEEVC
S37-p AMTEHKMsVEEVCRK
K44 sVEEVCRKyNTDCVQ
Y45-p VEEVCRKyNTDCVQG
S56 CVQGLTHSkAQEILA
K57-ub VQGLTHSkAQEILAR
T71 RDGPNALTPPPTTPE
K146 YQEAKSSKIMESFkN
K152-ub SKIMESFkNMVPQQA
K167 LVIREGEKMQVNAEE
K184-ub VGDLVEIkGGDRVPA
S197 PADLRIISAHGCkVD
K202-ub IISAHGCkVDNSsLT
S207-p GCkVDNSsLTGEsEP
T209 kVDNSsLTGEsEPQT
S212-p NSsLTGEsEPQTRsP
T216 TGEsEPQTRsPDCTH
S218-p EsEPQTRsPDCTHDN
T237 RNITFFSTNCVEGTA
T255 VVATGDRTVMGRIAT
T262 TVMGRIATLASGLEV
S265 GRIATLASGLEVGKT
K349 ARKNCLVKNLEAVET
K367 TSTICSDKtGTLTQN
K367 TSTICSDKtGTLTQN
T368-p STICSDKtGTLTQNR
K424-ub LCNRAVFkGGQDNIP
K434-ac QDNIPVLkRDVAGDA
K434-ub QDNIPVLkRDVAGDA
S442-p RDVAGDAsESALLKC
S444 VAGDAsESALLKCIE
K448 AsESALLKCIELSSG
S453 LLKCIELSSGSVkLM
S454 LKCIELSSGSVkLMR
S456 CIELSSGSVkLMRER
K458 ELSSGSVKLMRERNK
K458-ub ELSSGSVkLMRERNK
K466 LMRERNKKVAEIPFN
S474-p VAEIPFNsTNKYQLS
K477 IPFNsTNKYQLSIHE
Y478 PFNsTNKYQLSIHET
S481 sTNKYQLSIHETEDP
T485 YQLSIHETEDPNDNR
Y493 EDPNDNRYLLVMKGA
K498 NRYLLVMKGAPERIL
K516 ATILLQGKEQPLDEE
K525 QPLDEEMKEAFQNAy
Y532-p KEAFQNAyLELGGLG
Y548-p RVLGFCHyyLPEEQF
Y549-p VLGFCHyyLPEEQFP
K595-ub AVPDAVGkCRSAGIK
T607 GIKVIMVTGDHPITA
K615 GDHPITAKAIAKGVG
K619 ITAKAIAKGVGIIsE
S625-p AKGVGIIsEGNETVE
T630 IIsEGNETVEDIAAR
S643-p ARLNIPVsQVNPRDA
K651-ub QVNPRDAkACVIHGT
T658 kACVIHGTDLkDFTS
K661-ub VIHGTDLkDFTSEQI
K688 ARTSPQQKLIIVEGC
S712-p TGDGVNDsPALkkAD
K716-ac VNDsPALkkADIGVA
K716-m2 VNDsPALkkADIGVA
K716-ub VNDsPALkkADIGVA
K717-ac NDsPALkkADIGVAM
K717-m2 NDsPALkkADIGVAM
K717-ub NDsPALkkADIGVAM
K763-m2 RLIFDNLkkSIAYTL
K763 RLIFDNLKkSIAYTL
K764-m2 LIFDNLkkSIAYTLT
K823 AAESDIMKRQPRNPR
T831 RQPRNPRTDkLVNER
K833-ub PRNPRTDkLVNERLI
S933 ICKTRRNSVFQQGMK
K940 SVFQQGMKNKILIFG
K1009 NPGGWVEKETyy___
T1011 GGWVEKETyy_____
Y1012-p GWVEKETyy______
Y1013-p WVEKETyy_______
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