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PGC-1 alpha
a transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor genes. Interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Regulates many genes involved in energy metabolism. Provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. May be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Its transcription is repressed by ZNF746 which binds to 'insulin response sequences' in its promoter. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator |
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Cellular Component: nucleoplasm; DNA-directed RNA polymerase II, core complex; cytosol; nucleus
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Molecular Function: ligand-dependent nuclear receptor binding; protein binding; DNA binding; androgen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; RNA binding; chromatin DNA binding; transcription coactivator activity; nucleotide binding; transcription factor binding
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Biological Process: mitochondrion organization and biogenesis; transcription initiation from RNA polymerase II promoter; response to muscle activity; protein stabilization; RNA splicing; positive regulation of transcription, DNA-dependent; cellular respiration; thermoregulation; gluconeogenesis; response to starvation; positive regulation of gluconeogenesis; digestion; androgen receptor signaling pathway; positive regulation of fatty acid oxidation; brown fat cell differentiation; cell glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter; fatty acid oxidation; protein complex assembly; positive regulation of histone acetylation; positive regulation of transcription factor activity; negative regulation of neuron apoptosis; mRNA processing
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Reference #:
Q9UBK2 (UniProtKB)
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| Alt. Names/Synonyms: LEM6; Ligand effect modulator 6; ligand effect modulator-6; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PGC-1(alpha); PGC-1-alpha; PGC-1v; PGC1; PGC1A; PPAR gamma coactivator variant form; PPAR gamma coactivator-1; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; PPARGC1; PPARGC1A; PRGC1 |
| Gene Symbols: PPARGC1A |
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Molecular weight: 91,027 Da
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Basal Isoelectric point: 5.71
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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mTOR Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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