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Protein Page:
SPTA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SPTA1 Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Defects in SPTA1 are the cause of elliptocytosis type 2 (EL2). EL2 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in SPTA1 are a cause of hereditary pyropoikilocytosis (HPP). HPP is an autosomal recessive disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells. Defects in SPTA1 are the cause of spherocytosis type 3 (SPH3); also known as hereditary spherocytosis type 3 (HS3). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive. Belongs to the spectrin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: spectrin; cytosol; actin cytoskeleton
Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton; protein heterodimerization activity; calcium ion binding
Biological Process: regulation of cell shape; axon guidance; plasma membrane organization and biogenesis; positive regulation of protein binding; actin filament capping; actin filament organization; hemopoiesis; positive regulation of T cell proliferation; lymphocyte homeostasis; porphyrin biosynthetic process
Reference #:  P02549 (UniProtKB)
Alt. Names/Synonyms: alpha-I spectrin; EL2; Erythroid alpha-spectrin; HPP; HS3; Spectrin alpha chain, erythrocyte; spectrin, alpha, erythrocytic 1; spectrin, alpha, erythrocytic 1 (elliptocytosis 2); SPH3; SPTA; SPTA1
Gene Symbols: SPTA1
Molecular weight: 280,014 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Select Structure to View Below

SPTA1

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: Y422‑p, Y548‑p, Y1499‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 8 S37-p EVLTRYQsFKERVAE
0 1 K59-ac SYHLQVFkRDADDLG
0 1 G251 AAWERLRGLALQRQK
0 2 A259 LALQRQKALsNAANL
0 1 S261-p LQRQKALsNAANLQR
0 1 K283-ac AIQWIKEkEPVLTSE
0 1 S299-p YGKDLVAsEGLFHSH
0 1 S317-p ERNLAVMsDKVKELC
0 5 Y370-p YEKLQATyWYHRFSS
0 1 K389 LSGWMNEKTAAINAD
1 1 Y422-p HKHEIDSyDDRFQSA
1 1 Y548-p KLIGDDHyDSENIKA
0 4 Y588-p SLLLQKLyEDSDDLK
0 1 K617 YKDIQNLKSRVQKQQ
0 1 T635-p KELAVNKtQLENIQK
0 1 S663 DNVTTRLSEVASLWE
0 1 Q700 ENNAEDLQRWLEDVE
0 1 T802 LQLICRDTEDEEAWI
0 1 T812-p EEAWIQEtEPSATsT
0 1 S818-p EtEPSATsTYLGKDL
0 1 S844-gl VILENIAsHEPRIQE
0 28 Y986-p EQRVMALyDFQARsP
0 1 S992-p LyDFQARsPREVTMK
0 4 Y1064-p QEQIENQyRSLLDRA
0 12 S1167-p ELNSRWGsLQRLADE
0 1 S1217 DPGSDLFSVQALQRR
0 1 S1250-gl GETAERLsESHPDAt
0 2 T1257-p sESHPDAtEDLQRQK
0 1 K1282 QGRTKDRKESLNEAQ
0 1 S1363-p IDSGHHAsPEIEKKL
0 1 S1424-p SLRSDDKssLDsLEA
0 1 S1425-p LRSDDKssLDsLEAL
0 3 S1428-p DDKssLDsLEALMKK
1 1 Y1499-p ERTKLGDyANLKQFY
0 8 Y1538-p ATNIQRKyLKHQTFA
0 1 K1579-ac DGNEEAMkEQLEQLk
0 1 K1586-ac kEQLEQLkEHWDHLL
0 1 A1640 KDQARDLASAGNLLK
0 1 K1647 ASAGNLLKKHQLLER
0 1 S1738-gl EKLIRVSsQDYGRDL
0 1 K1803-ub QFVEHWEkLKELAKA
0 1 S1901-p SQNKEISsKIEALNE
0 1 T1910-p IEALNEKtPsLAKAI
0 1 S1912-p ALNEKtPsLAKAIAA
0 1 S1976-p KQDTLDAsLQSFQQE
0 2 K2051-ac LFVEFAHkASALNNW
0 1 K2200-ac ESQLEANkRKQKEIQ
0 1 K2202 QLEANkRKQKEIQAM
0 1 K2210 QKEIQAMKRQLTKIV
0 1 K2274 GVSEETLKEFSTIYK
0 1 K2281 KEFSTIYKHFDENLT
0 1 K2321 EHEPKFEKFLDAVDP
0 42 Y2333-p VDPGRKGyVSLEDYT
0 1 S2405-p PRGRSHLsGyDYVGF
0 1 Y2407-p GRSHLsGyDYVGFTN
  mouse

 
R36 EVLNQYQRFKDRVAE
R58 SYHYQVFRRDADDLE
S249-p AAWDRLWsLALKRRE
S257-p LALKRREsLsNAADL
S259-p LKRREsLsNAADLQR
K281 AIQWMEEKEPQLTSE
S297 YGKDLVSSEALFHNH
D315 ERNLAVMDDKVKELC
Y368 YAKLKASYGYHRFLS
K387-ac LSGWMKEkTALINAD
Y420 HKHEIDSYDDRFQSA
Y546 KLIDNDHYDSENIAA
Y586 SQLLQQLYQDSDDLK
K615-ub YKDVQNLkSRVQKQQ
I633 EELAVNEIMLNNLEK
S661-p EAVAARLsEVANLWK
K698-ub ENNAEDLkRWLEEVE
S800-p LQQICRDsEDEEAWI
T810 EEAWIQETEPSAAST
S816 ETEPSAASTHLGKDL
S842 VILADIASHEPRIQV
Y984 EARVIALYDFEARSR
S990 LYDFEARSRREVSMK
Y1062 QQQVETLYHSLLDRA
S1165-p ELNTRWNsLKRLADE
S1215 DPGSDLLSVQALQRQ
C1248 GETAERLCESHPDAT
T1255 CESHPDATEDLQKQR
K1280-ac QGLTSDRkESLNEAH
R1361 IDSGHRNRREIDNTL
D1422 SLRSDDRDHLNsLQA
H1423 LRSDDRDHLNsLQAL
S1426-p DDRDHLNsLQALMKK
Y1497 ELGKLGDYADLKQFY
Y1536 PTNIQRKYLKHQAFE
Q1577 DGDEENMQEQLDKLK
K1584 QEQLDKLKENWDYLL
T1638-p KDQARDLtSAGNLLk
K1645-ub tSAGNLLkKHQLLEA
S1736 EKLLRVSSQDYGRDL
K1801 QFVQHWEKLKELAKT
T1897 QNKDKISTKIQVLNE
T1906 IQVLNEKTASLAKAL
S1908 VLNEKTASLAKALAA
S1972 KHDTLDASLQSFQQE
K2047 LFMEFAHKASAFNNW
K2196 ESQLEANKRkQKEIQ
K2198-m1 QLEANKRkQKEIQAM
K2206-m1 QKEIQAMkRHLTKIE
K2270-ub GVSEETLkEFSTTYk
K2277-ub kEFSTTYkHFDENLT
K2317-ub EPEPKFEkFLNAVDP
Y2329 VDPGRKGYVSLEDYT
A2401 PRGRSQPAGYDYVGF
Y2403 GRSQPAGYDYVGFTN
  rat

 
R36 EVLDQYQRFKERVAE
R58 SYHYQVFRRDADDLE
S249 AAWDRLWSLALKRRE
S257 LALKRRESLSNAADL
S259 LKRRESLSNAADLQR
K281 AIQWMEEKEPLLTSE
S297 YGKDLVSSEALFHSH
D315 ERNLAVMDDKVKELC
Y368 YAKLKASYGYHRFLS
K387 LTGWMEEKTALINAD
Y420 HKHEIDSYDDRFQTA
Y546 KLIDNDHYDSENIAA
Y586 SQLLQQLYQDSDDLK
K615 YKDVQNLKSRVQKQQ
I633 EELAANEIMLNNLER
S661 DAVAARMSEVANLWK
K698 ENNAEDLKRWLEEVE
S800 LQQICRDSEDEEAWI
T810 EEAWIQETEPSAAST
S816 ETEPSAASTHLGKDL
S842 VILADIASHEPRIQT
Y984 EARVIALYDFEARSR
S990 LYDFEARSRREVSMK
Y1062 QEQIETLYHSLLDRA
S1165 ELNTRWSSLKRLADE
S1215-p DPGSDLLsVQALQRQ
C1248 GETAERLCESHPDAT
T1255 CESHPDATEDLQKQR
K1280 QGLTSDRKESLNEAH
S1361 IDRGHRNSHEIETTL
D1422 SLRSDDRDHLNSLQA
H1423 LRSDDRDHLNSLQAL
S1426 DDRDHLNSLQALMKK
Y1497 ELGKLGDYADLKQFY
Y1537 TNIQQRKYLKHQAFE
Q1578 DGDEENMQEQLDKLK
K1585 QEQLDKLKENWDYLL
T1639 KDQARDLTSAGNLLK
K1646 TSAGNLLKKHQLLEA
S1737 EKLLRVSSQDCGRDL
K1802 QFVQHWEKLKELAKT
T1898 QNKDKISTKIEVLNE
T1907 IEVLNEKTASLTKAL
S1909 VLNEKTASLTKALAA
S1973 KQDTLDASLQSFQQE
K2048 LFMEFAHKASAFNNW
K2197 ESQLEANKRKQKEIQ
K2199 QLEANKRKQKEIQAM
K2207 QKEIQAMKRHLTKIE
K2271 GVSEETLKEFSTTYK
K2278 KEFSTTYKHFDENLT
K2318 EPEPKFEKFLNAVDP
Y2330 VDPGRKGYVSLEDYT
A2402 PRGRSQPAGYDYVGF
Y2404 GRSQPAGYDYVGFTN
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