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NPM1 (human)

Overview NPM1 a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: RNA binding protein; Translation Cellular Component: nucleoplasm; centrosome; cytoplasm; nucleolus; spindle pole centrosome; ribonucleoprotein complex; nucleus Molecular Function: NF-kappaB binding; protein binding; protein homodimerization activity; histone binding; Tat protein binding; protein heterodimerization activity; RNA binding; transcription coactivator activity; unfolded protein binding; protein kinase binding; ribosomal small subunit binding; ribosomal large subunit binding Biological Process: regulation of centriole replication; centrosome cycle; cell aging; nucleocytoplasmic transport; DNA repair; signal transduction; protein oligomerization; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; intracellular protein transport; nucleosome assembly; protein localization; regulation of endodeoxyribonuclease activity; DNA replication-independent nucleosome assembly at centromere; ribosome assembly; virus-host interaction; response to stress; negative regulation of apoptosis Reference #:  P06748 (UniProtKB) Alt. Names/Synonyms: B23; MGC104254; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin); nucleophosmin/nucleoplasmin family, member 1; Numatrin Gene Symbols: NPM1 Molecular weight: 32,575 Da Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NPM1 2LLH - A=225-294 (human) 2P1B - A/B/C/D/E/F/G/H/I/J=9-124 (human) 2VXD - A=214-265 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2LLH 2P1B 2VXD  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: S4‑p, S10‑p, S70‑p, T234‑p, T237‑p cytoskeletal reorganization: S4‑p transcription, altered: T199‑p, K212‑a, K215‑a, K229‑a, K230‑a, K257‑a, K267‑a, K292‑a acetylation: T199‑p inhibition: T199‑p intracellular localization: S10‑p, S70‑p, K212‑a, K215‑a, K229‑a, K230‑a, T234‑p, T237‑p, K257‑a, K267‑a, K292‑a molecular association, regulation: S10‑p, S70‑p, T199‑p, K212‑a, K215‑a, T219‑p, K229‑a, K230‑a, T234‑p, T237‑p, K257‑a, K267‑a, K292‑a phosphorylation: S10‑p, S70‑p ubiquitination: T199‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
3	10		S4-p	____MEDsMDMDMsP
1	6		S10-p	DsMDMDMsPLRPQNy
0	3		Y17-p	sPLRPQNyLFGCELK
0	8		K27-u	GCELKADkDyHFkVD
0	44		Y29-p	ELKADkDyHFkVDND
0	17		K32-a	ADkDyHFkVDNDENE
0	13		K32-u	ADkDyHFkVDNDENE
0	1		S43	DENEHQLSLRTVSLG
0	1		K54-a	VSLGAGAkDELHIVE
0	18		K54-u	VSLGAGAkDELHIVE
0	14		Y67-p	VEAEAMNyEGsPIKV
3	62		S70-p	EAMNyEGsPIKVtLA
0	3		T75-p	EGsPIKVtLAtLkMS
0	1		T78-p	PIKVtLAtLkMSVQP
0	4		K80-u	KVtLAtLkMSVQPTV
0	1		S82	tLAtLkMSVQPTVsL
0	3		S88-p	MSVQPTVsLGGFEIt
1	23		T95-p	sLGGFEItPPVVLRL
1	9		S106-p	VLRLKCGsGPVHIsG
0	4		S112-p	GsGPVHIsGQHLVAV
3	546		S125-p	AVEEDAEsEDEEEED
0	8		S137-p	EEDVKLLsIsGkRsA
0	5		S139-p	DVKLLsIsGkRsAPG
0	139		K141-a	KLLsIsGkRsAPGGG
0	5		K141-u	KLLsIsGkRsAPGGG
0	4		S143-p	LsIsGkRsAPGGGSk
0	63		K150-a	sAPGGGSkVPQkkVk
0	1		K150-u	sAPGGGSkVPQkkVk
0	231		K154-a	GGSkVPQkkVkLAAD
0	1		K154-u	GGSkVPQkkVkLAAD
0	16		K155-a	GSkVPQkkVkLAADE
0	1		K155-u	GSkVPQkkVkLAADE
0	1		K157-u	kVPQkkVkLAADEDD
0	1		A186	DDFDDEEAEEkAPVk
0	1		K189-u	DDEEAEEkAPVkKsI
0	1		K193-u	AEEkAPVkKsIRDtP
0	8		S195-p	EkAPVkKsIRDtPAk
0	1		D198	PVkKsIRDtPAkNAQ
15	33		T199-p	VkKsIRDtPAkNAQK
0	2		K202-u	sIRDtPAkNAQKSNQ
1	34		K212-a	QKSNQNGkDskPsst
0	2		S214-p	SNQNGkDskPsstPR
1	1		K215-a	NQNGkDskPsstPRs
0	1		S217-p	NGkDskPsstPRskG
0	10		S218-p	GkDskPsstPRskGQ
1	25		T219-p	kDskPsstPRskGQE
0	2		S222-p	kPsstPRskGQEsFk
0	2		K223	PsstPRsKGQEsFkk
0	1		K223-u	PsstPRskGQEsFkk
0	6		S227-p	PRskGQEsFkkQEKt
1	105		K229-a	skGQEsFkkQEKtPK
0	1		K229-u	skGQEsFkkQEKtPK
1	5		K230-a	kGQEsFkkQEKtPKt
3	0		K230-s	kGQEsFkkQEKtPKt
4	20		T234-p	sFkkQEKtPKtPkGP
4	25		T237-p	kQEKtPKtPkGPssV
0	3		K239-u	EKtPKtPkGPssVED
0	4		S242-p	PKtPkGPssVEDIkA
0	21		S243-p	KtPkGPssVEDIkAk
0	14		K248-u	PssVEDIkAkMQAsI
0	9		K250-u	sVEDIkAkMQAsIEk
0	24		S254-p	IkAkMQAsIEkGGsL
1	3		K257-a	kMQAsIEkGGsLPkV
0	10		K257-u	kMQAsIEkGGsLPkV
0	11		S260-p	AsIEkGGsLPkVEAk
0	2		K263-u	EkGGsLPkVEAkFIN
3	0		K263-s	EkGGsLPkVEAkFIN
3	123		K267-a	sLPkVEAkFINYVkN
0	37		K267-u	sLPkVEAkFINYVkN
1	15		K273-a	AkFINYVkNCFRMtD
0	18		K273-u	AkFINYVkNCFRMtD
0	11		T279-p	VkNCFRMtDQEAIQD
1	1		K292-a	QDLWQWRksL_____
0	9		S293-p	DLWQWRksL______

	NPM1 iso2
S4	____MEDSMDMDMSP
S10	DSMDMDMSPLRPQNY
Y17	SPLRPQNYLFGCELK
K27	GCELKADKDyHFKVD
Y29-p	ELKADKDyHFKVDND
K32	ADKDyHFKVDNDENE
K32	ADKDyHFKVDNDENE
S43	DENEHQLSLRTVSLG
K54	VSLGAGAKDELHIVE
K54	VSLGAGAKDELHIVE
Y67	VEAEAMNYEGSPIKV
S70	EAMNYEGSPIKVTLA
T75	EGSPIKVTLATLKMS
T78	PIKVTLATLKMSVQP
K80	KVTLATLKMSVQPTV
S82	TLATLKMSVQPTVSL
S88	MSVQPTVSLGGFEIt
T95-p	SLGGFEItPPVVLRL
S106	VLRLKCGSGPVHISG
S112	GSGPVHISGQHLVAV
S125	AVEEDAESEDEEEED
S137-p	EEDVKLLsISGkRsA
S139	DVKLLsISGkRsAPG
K141-a	KLLsISGkRsAPGGG
K141	KLLsISGKRsAPGGG
S143-p	LsISGkRsAPGGGSk
K150-a	sAPGGGSkVPQkkVK
K150	sAPGGGSKVPQkkVK
K154-a	GGSkVPQkkVKLAAD
K154	GGSkVPQKkVKLAAD
K155-a	GSkVPQkkVKLAADE
K155	GSkVPQkKVKLAADE
K157	kVPQkkVKLAADEDD
A186	DDFDDEEAEEKAPVK
K189	DDEEAEEKAPVKKGQ
K193	AEEKAPVKKGQEsFk
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
K194	EEKAPVKKGQEsFkK
S198-p	PVKKGQEsFkKQEKT
K200-a	KKGQEsFkKQEKTPK
K200	KKGQEsFKKQEKTPK
K201	KGQEsFkKQEKTPKT
K201	KGQEsFkKQEKTPKT
T205	sFkKQEKTPKTPKGP
T208	KQEKTPKTPKGPSSV
K210	EKTPKTPKGPSSVED
S213	PKTPKGPSSVEDIKA
S214	KTPKGPSSVEDIKAK
K219	PSSVEDIKAKMQASI
K221	SVEDIKAKMQASIEK
S225	IKAKMQASIEKGGSL
K228	KMQASIEKGGSLPKV
K228	KMQASIEKGGSLPKV
S231	ASIEKGGSLPKVEAk
K234	EKGGSLPKVEAkFIN
K234	EKGGSLPKVEAkFIN
K238-a	SLPKVEAkFINYVKN
K238	SLPKVEAKFINYVKN
K244	AkFINYVKNCFRMtD
K244	AkFINYVKNCFRMtD
T250-p	VKNCFRMtDQEAIQD
K263	QDLWQWRKSL_____
S264	DLWQWRKSL______

	NPM1 iso3
S4	____MEDSMDMDMSP
S10	DSMDMDMSPLRPQNY
Y17	SPLRPQNYLFGCELK
K27	GCELKADKDYHFKVD
Y29	ELKADKDYHFKVDND
K32	ADKDYHFKVDNDENE
K32	ADKDYHFKVDNDENE
S43	DENEHQLSLRTVSLG
K54	VSLGAGAKDELHIVE
K54	VSLGAGAKDELHIVE
Y67	VEAEAMNYEGSPIKV
S70	EAMNYEGSPIKVTLA
T75	EGSPIKVTLATLKMS
T78	PIKVTLATLKMSVQP
K80	KVTLATLKMSVQPTV
S82	TLATLKMSVQPTVSL
S88	MSVQPTVSLGGFEIT
T95	SLGGFEITPPVVLRL
S106	VLRLKCGSGPVHISG
S112	GSGPVHISGQHLVAV
S125	AVEEDAESEDEEEED
S137	EEDVKLLSISGKRSA
S139	DVKLLSISGKRSAPG
K141	KLLSISGKRSAPGGG
K141	KLLSISGKRSAPGGG
S143	LSISGKRSAPGGGSK
K150	SAPGGGSKVPQKKVK
K150	SAPGGGSKVPQKKVK
K154	GGSKVPQKKVKLAAD
K154	GGSKVPQKKVKLAAD
K155	GSKVPQKKVKLAADE
K155	GSKVPQKKVKLAADE
K157	KVPQKKVKLAADEDD
A186	DDFDDEEAEEKAPVK
K189	DDEEAEEKAPVKKSI
K193	AEEKAPVKKSIRDTP
S195	EKAPVKKSIRDTPAK
D198	PVKKSIRDTPAKNAQ
T199	VKKSIRDTPAKNAQK
K202	SIRDTPAKNAQKSNQ
K212	QKSNQNGKDSKPSST
S214	SNQNGKDSKPSSTPR
K215	NQNGKDSKPSSTPRS
S217	NGKDSKPSSTPRSKG
S218	GKDSKPSSTPRSKGQ
T219	KDSKPSSTPRSKGQE
S222	KPSSTPRSKGQESFK
K223	PSSTPRSKGQESFKK
K223	PSSTPRSKGQESFKK
S227	PRSKGQESFKKQEKT
K229	SKGQESFKKQEKTPK
K229	SKGQESFKKQEKTPK
K230	KGQESFKKQEKTPKT
K230	KGQESFKKQEKTPKT
T234	SFKKQEKTPKTPKGP
T237	KQEKTPKTPKGPSSV
K239	EKTPKTPKGPSSVED
S242	PKTPKGPSSVEDIKA
S243	KTPKGPSSVEDIKAK
K248	PSSVEDIKAKMQAsI
K250	SVEDIKAKMQAsIEk
S254-p	IKAKMQAsIEkAH__
K257-a	KMQAsIEkAH_____
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse
S4-p	____MEDsMDMDMsP
S10-p	DsMDMDMsPLRPQNy
Y17-p	sPLRPQNyLFGCELK
K27-u	GCELKADkDyHFkVD
Y29-p	ELKADkDyHFkVDND
K32-a	ADkDyHFkVDNDENE
K32-u	ADkDyHFkVDNDENE
S43-p	DENEHQLsLRTVSLG
K54	VSLGAGAKDELHIVE
K54-u	VSLGAGAkDELHIVE
Y67-p	VEAEAMNyEGsPIKV
S70-p	EAMNyEGsPIKVtLA
T75-p	EGsPIKVtLATLKMs
T78	PIKVtLATLKMsVQP
K80	KVtLATLKMsVQPTV
S82-p	tLATLKMsVQPTVSL
S88	MsVQPTVSLGGFEIT
T95	SLGGFEITPPVVLRL
S106-p	VLRLKCGsGPVHIsG
S112-p	GsGPVHIsGQHLVAV
S125-p	AVEEDAEsEDEDEED
G137	EEDVKLLGMsGkRsA
S139-p	DVKLLGMsGkRsAPG
K141-a	KLLGMsGkRsAPGGG
K141-u	KLLGMsGkRsAPGGG
S143-p	LGMsGkRsAPGGGNk
K150-a	sAPGGGNkVPQkkVK
K150	sAPGGGNKVPQkkVK
K154-a	GGNkVPQkkVKLDED
K154-u	GGNkVPQkkVKLDED
K155-a	GNkVPQkkVKLDEDD
K155	GNkVPQkKVKLDEDD
K157	kVPQkkVKLDEDDED
T185-p	DDFDEEEtEEKVPVK
K188	DEEEtEEKVPVKKsV
K192	tEEKVPVKKsVRdtP
S194-p	EKVPVKKsVRdtPAK
D197-ca	PVKKsVRdtPAKNAQ
T198-p	VKKsVRdtPAKNAQK
K201	sVRdtPAKNAQKSNQ
K211-a	QKSNQNGkDLKPstP
L213	SNQNGkDLKPstPRS
K214	NQNGkDLKPstPRSk
-	gap
S216-p	NGkDLKPstPRSkGQ
T217-p	GkDLKPstPRSkGQE
S220	LKPstPRSkGQEsFk
K221-a	KPstPRSkGQEsFkk
K221	KPstPRSKGQEsFkk
S225-p	PRSkGQEsFkkQEKt
K227-a	SkGQEsFkkQEKtPK
K227	SkGQEsFKkQEKtPK
K228-a	kGQEsFkkQEKtPKt
K228	kGQEsFkKQEKtPKt
T232-p	sFkkQEKtPKtPkGP
T235-p	kQEKtPKtPkGPssV
K237-u	EKtPKtPkGPssVED
S240-p	PKtPkGPssVEDIkA
S241-p	KtPkGPssVEDIkAk
K246-u	PssVEDIkAkMQAsI
K248-u	sVEDIkAkMQAsIEk
S252-p	IkAkMQAsIEkGGsL
K255-a	kMQAsIEkGGsLPkV
K255-u	kMQAsIEkGGsLPkV
S258-p	AsIEkGGsLPkVEAk
K261-u	EkGGsLPkVEAkFIN
K261	EkGGsLPKVEAkFIN
K265-a	sLPkVEAkFINYVkN
K265-u	sLPkVEAkFINYVkN
K271-a	AkFINYVkNCFRMTD
K271-u	AkFINYVkNCFRMTD
T277	VkNCFRMTDQEAIQD
K290	QDLWQWRKSL_____
S291	DLWQWRKSL______

	rat
S4	____MEDSMDMDMSP
S10	DSMDMDMSPLRPQNY
Y17	SPLRPQNYLFGCELK
K27	GCELKADKDYHFKVD
Y29	ELKADKDYHFKVDND
K32	ADKDYHFKVDNDENE
K32	ADKDYHFKVDNDENE
S43	DENEHQLSLRTVSLG
K54	VSLGAGAKDELHIVE
K54	VSLGAGAKDELHIVE
Y67-p	VEAEAMNyEGsPIKV
S70-p	EAMNyEGsPIKVTLA
T75	EGsPIKVTLATLKMS
T78	PIKVTLATLKMSVQP
K80	KVTLATLKMSVQPTV
S82	TLATLKMSVQPTVSL
S88	MSVQPTVSLGGFEIT
T95	SLGGFEITPPVVLRL
S106-p	VLRLKCGsGPVHISG
S112	GsGPVHISGQHLVAV
S125-p	AVEEDAEsEDEDEED
G137	EEDVKLLGMSGKRSA
S139	DVKLLGMSGKRSAPG
K141	KLLGMSGKRSAPGGG
K141	KLLGMSGKRSAPGGG
S143	LGMSGKRSAPGGGNK
K150	SAPGGGNKVPQKKVK
K150	SAPGGGNKVPQKKVK
K154	GGNKVPQKKVKLDED
K154	GGNKVPQKKVKLDED
K155	GNKVPQKKVKLDEDD
K155	GNKVPQKKVKLDEDD
K157	KVPQKKVKLDEDDDE
T185	DDFDEEETEEKVPVK
K188	DEEETEEKVPVKKSV
K192	TEEKVPVKKSVRDTP
S194	EKVPVKKSVRDTPAK
D197	PVKKSVRDTPAKNAQ
T198	VKKSVRDTPAKNAQK
K201	SVRDTPAKNAQKSNQ
K211	QKSNQNGKDLKPSTP
L213	SNQNGKDLKPSTPRS
K214	NQNGKDLKPSTPRSK
-	gap
S216	NGKDLKPSTPRSKGQ
T217	GKDLKPSTPRSKGQE
S220	LKPSTPRSKGQESFK
K221	KPSTPRSKGQESFKK
K221	KPSTPRSKGQESFKK
S225	PRSKGQESFKKQEKT
K227	SKGQESFKKQEKTPK
K227	SKGQESFKKQEKTPK
K228	KGQESFKKQEKTPKt
K228	KGQESFKKQEKTPKt
T232	SFKKQEKTPKtPKGP
T235-p	KQEKTPKtPKGPSsV
K237	EKTPKtPKGPSsVED
S240	PKtPKGPSsVEDIKA
S241-p	KtPKGPSsVEDIKAK
K246	PSsVEDIKAKMQASI
K248	sVEDIKAKMQASIEK
S252	IKAKMQASIEKGGsL
K255	KMQASIEKGGsLPKV
K255	KMQASIEKGGsLPKV
S258-p	ASIEKGGsLPKVEAk
K261	EKGGsLPKVEAkFIN
K261	EKGGsLPKVEAkFIN
K265-a	sLPKVEAkFINYVKN
K265	sLPKVEAKFINYVKN
K271	AkFINYVKNCFRMTD
K271	AkFINYVKNCFRMTD
T277	VKNCFRMTDQEAIQD
K290	QDLWQWRKSL_____
S291	DLWQWRKSL______

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