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Protein Page:
TORC1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TORC1 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons. Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax. Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. Belongs to the TORC family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: cytoplasm; nucleolus; plasma membrane; nucleus
Molecular Function: protein binding; cAMP response element binding protein binding
Biological Process: transcription, DNA-dependent; viral reproduction; activation of CREB transcription factor; positive regulation of transcription from RNA polymerase II promoter; protein homotetramerization
Reference #:  Q6UUV9 (UniProtKB)
Alt. Names/Synonyms: CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; CRTC1; FLJ14027; KIAA0616; MECT1; mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; TORC1; Transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1; WAMTP1
Gene Symbols: CRTC1
Molecular weight: 67,300 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TORC1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K47-u AARLQLQkSQyLQLG
0 3 Y50-p LQLQkSQyLQLGPSR
0 2 S64-p RGQYYGGsLPNVNQI
0 1 S113-p RERGRLGsPHRRPLS
0 3 Y133 RQADSCPYGTMYLsP
0 10 S139-p PYGTMYLsPPADTSW
0 13 S151-p TSWRRTNsDsALHQS
0 1 S153-p WRRTNsDsALHQSTM
0 1 T161-p ALHQSTMtPTQPESF
0 1 T163 HQSTMtPTQPESFSS
1 0 S167 MtPTQPESFSSGsQD
0 3 S172-p PESFSSGsQDVHQKR
0 3 S330-p QQASPTLsPLSPITQ
3359 : Phospho-Torc1/Crtc1 (Ser151) Antibody
  mouse

 
K47 AARLQLQKSQYLQLG
Y50 LQLQKSQYLQLGPSR
S64-p RGQYYGGsLPNVNQI
S113 RERGRLGSPHRRPLS
Y133-p RQADSCPyGTVYLsP
S139-p PyGTVYLsPPADTSW
S151-p TSWRRTNsDSALHQS
S153 WRRTNsDSALHQSTM
T161 ALHQSTMTPsQAESF
S163-p HQSTMTPsQAESFTG
S167 MTPsQAESFTGGSQD
S172 AESFTGGSQDAHQKR
S329 QQVSPTLSPLSPITQ
3359 : Phospho-Torc1/Crtc1 (Ser151) Antibody
  rat

 
K47 AARLQLQKSQYLQLG
Y50 LQLQKSQYLQLGPSR
S64 RGQYYGGSLPNVNQI
S113 RERGRLGSPHRRPLS
Y133 RQADSCPYGTVYLSP
S139 PYGTVYLSPPADTSW
S151 TSWRRTNSDSALHQS
S153 WRRTNSDSALHQSTM
T161 ALHQSTMTPTQAEsF
T163 HQSTMTPTQAEsFTG
S167-p MTPTQAEsFTGGPQD
P172 AEsFTGGPQDAHQKR
S329 QQVPPTLSPLSPITQ
3359 : Phospho-Torc1/Crtc1 (Ser151) Antibody
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