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Overview |
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PIP5K1A
Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs. Interacts with RAC1. Interacts with TUT1. Forms a complex with CDH1/E-cadherin, CTNNB1/beta-catenin and CTNND1 at the plasma membrane upon calcium stimulation. Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; EC 2.7.1.68; Kinase, lipid |
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Cellular Component: lamellipodium; cytoplasm; nucleolus; plasma membrane; nuclear speck; mRNA cleavage and polyadenylation specificity factor complex; nucleus; cytosol
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Molecular Function: protein binding; 1-phosphatidylinositol-4-phosphate 5-kinase activity; kinase binding; ATP binding
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Biological Process: keratinocyte differentiation; focal adhesion formation; cell migration; activation of Rac GTPase; phospholipid metabolic process; actin cytoskeleton reorganization; phosphatidylinositol biosynthetic process; glycerophospholipid metabolic process; signal transduction; phosphorylation; phagocytosis; phospholipid biosynthetic process
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Reference #:
Q99755 (UniProtKB)
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| Alt. Names/Synonyms: 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha; Phosphatidylinositol-4-phosphate 5-kinase type I alpha; Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PI51A; PIP5K1-alpha; PIP5K1A; PIP5KIalpha; PtdIns(4)P-5-kinase 1 alpha |
| Gene Symbols: PIP5K1A |
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Molecular weight: 62,633 Da
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Basal Isoelectric point: 8.41
Predict pI for various phosphorylation states
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CST Pathways:
PI3K/Akt Signaling
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Regulation of Actin Dynamics
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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Select Structure to View Below |
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PIP5K1A |
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