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Protein Page:
GALNT3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GALNT3 an enzyme that catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. A single-pass type II membrane protein that localizes to the Golgi apparatus membrane. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Plays a central role in phosphate homeostasis. Mutations cause cause familial tumoral calcinosis, a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Overexpressed in many differentiated carcinomas, suggesting that it may serve as a marker of tumor differentiation. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transferase; EC 2.4.1.41; Membrane protein, integral; Glycan Metabolism - O-glycan biosynthesis
Cellular Component: Golgi membrane; Golgi apparatus; membrane; perinuclear region of cytoplasm; integral to membrane
Molecular Function: manganese ion binding; polypeptide N-acetylgalactosaminyltransferase activity; calcium ion binding
Biological Process: cellular protein metabolic process; O-glycan processing; carbohydrate metabolic process; protein amino acid O-linked glycosylation via threonine; post-translational protein modification; protein amino acid O-linked glycosylation via serine
Reference #:  Q14435 (UniProtKB)
Alt. Names/Synonyms: DKFZp686C10199; GalNAc transferase 3; GalNAc-T3; GALNT3; GALT3; HFTC; HHS; MGC61909; Polypeptide GalNAc transferase 3; polypeptide GalNAc-transferase T3; Polypeptide N-acetylgalactosaminyltransferase 3; pp-GaNTase 3; Protein-UDP acetylgalactosaminyltransferase 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
Gene Symbols: GALNT3
Molecular weight: 72,610 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
Select Structure to View Below

GALNT3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T130-ga ASGKAFKttNLSVEE
0 1 T131-ga SGKAFKttNLSVEEQ
0 1 S368 TFAGGLFSISKEYFE
0 1 S370 AGGLFSISKEYFEYI
0 1 K460-ac RRNTDAAkIVKQKAF
0 1 K472-ac KAFGDLSkRFEIKHR
0 1 Y598-p IQKDQLLyNPFLKMC
0 1 K626-ac NPSDPLQkWILSQND
  mouse

 
I130 ASGKPFKITHLSPEE
T131 SGKPFKITHLSPEEQ
S368-p TFAGGLFsIsKKYFE
S370-p AGGLFsIsKKYFEHI
K460 RRNTDAAKIVKQKSF
K472 KSFGDLSKRFEIKKR
Y598 IRKDQLLYNPLFKMC
K626 DATDLLQKWIFSQND
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