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GALNT3
an enzyme that catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. A single-pass type II membrane protein that localizes to the Golgi apparatus membrane. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Plays a central role in phosphate homeostasis. Mutations cause cause familial tumoral calcinosis, a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Overexpressed in many differentiated carcinomas, suggesting that it may serve as a marker of tumor differentiation. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Transferase; Membrane protein, integral; Glycan Metabolism - O-glycan biosynthesis; EC 2.4.1.41 |
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Cellular Component: Golgi membrane; Golgi apparatus; membrane; perinuclear region of cytoplasm; cytoplasm; integral to membrane; nucleus
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Molecular Function: polypeptide N-acetylgalactosaminyltransferase activity; manganese ion binding; calcium ion binding
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Biological Process: cellular protein metabolic process; O-glycan processing; carbohydrate metabolic process; protein amino acid O-linked glycosylation via threonine; post-translational protein modification; protein amino acid O-linked glycosylation via serine
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Reference #:
Q14435 (UniProtKB)
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| Alt. Names/Synonyms: DKFZp686C10199; GalNAc transferase 3; GalNAc-T3; GALNT3; GALT3; HFTC; HHS; MGC61909; Polypeptide GalNAc transferase 3; polypeptide GalNAc-transferase T3; Polypeptide N-acetylgalactosaminyltransferase 3; pp-GaNTase 3; Protein-UDP acetylgalactosaminyltransferase 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) |
| Gene Symbols: GALNT3 |
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Molecular weight: 72,610 Da
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Basal Isoelectric point: 8.2
Predict pI for various phosphorylation states
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