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Protein Page:
FGFR3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGFR3 a receptor tyrosine kinase of the highly-conserved FGFR family that binds fibroblast growth factor (FGF). Mutations are associated with thanatophoric dysplasia (TD), craniosynostosis Adelaide type, many craniosynostotic syndromes and bone malformations. Three splice-variant isoforms have been described. Activating point mutations cause dwarfism, including achondroplasia, hypochrondroplasia and thanatophoric dysplasia, and facial and other morphogenetic disorders, including Crouzon syndrome, craniosynostosis Adelaide type, San Diego skeletal displasia and Muenke syndrome. Translocations t(4;14) involving the IgH region are common in multiple myeloma and frequently involve FGFR3. Activated FGFR3 found in 30% of bladder cancers and several cervical cancers, but not in other tumors. Two mutations found in colorectal cancer. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; TK group; FGFR family
Cellular Component: internal side of plasma membrane; focal adhesion; cell surface; integral to plasma membrane; lysosome; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; extracellular region; plasma membrane; nucleus
Molecular Function: protein binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; somatic stem cell maintenance; protein amino acid autophosphorylation; negative regulation of transcription from RNA polymerase II promoter; bone mineralization; positive regulation of tyrosine phosphorylation of Stat3 protein; substantia nigra development; positive regulation of MAPKKK cascade; cell-cell signaling; inner ear receptor cell differentiation; positive regulation of neuron apoptosis; positive regulation of cell proliferation; morphogenesis of an epithelium; chondrocyte differentiation; response to axon injury; skeletal development; negative regulation of epithelial cell proliferation; endochondral ossification; epidermal growth factor receptor signaling pathway; negative regulation of developmental growth; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; myelination in the central nervous system; MAPKKK cascade; positive regulation of phosphoinositide 3-kinase activity; digestive tract morphogenesis; JAK-STAT cascade; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of protein ubiquitination; negative regulation of smoothened signaling pathway; negative regulation of astrocyte differentiation; negative regulation of mitosis; insulin receptor signaling pathway; innate immune response; positive regulation of endothelial cell proliferation; lens morphogenesis in camera-type eye; positive regulation of cell differentiation
Reference #:  P22607 (UniProtKB)
Alt. Names/Synonyms: ACH; achondroplasia, thanatophoric dwarfism; CD333; CEK2; FGFR-3; FGFR3; Fibroblast growth factor receptor 3; HSFGFR3EX; JTK4; tyrosine kinase JTK4
Gene Symbols: FGFR3
Molecular weight: 87,710 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FGFR3

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: Y577‑p, Y724‑p, Y760‑p, Y770‑p
transcription, altered: Y724‑p
enzymatic activity, induced: Y724‑p, Y760‑p
molecular association, regulation: Y724‑p, Y760‑p
phosphorylation: Y724‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S408-p PPKKGLGsPTVHKIS
0 1 S424 FPLKRQVSLESNASM
0 1 S430 VSLESNASMSSNTPL
0 1 T435 NASMSSNTPLVRIAR
0 8 S444-p LVRIARLssGEGPTL
0 9 S445-p VRIARLssGEGPTLA
0 1 K530-ac VSEMEMMkMIGKHKN
0 2 Y552 CTQGGPLYVLVEYAA
1 10 Y577-p RRPPGLDysFDTCKP
0 1 S578-p RPPGLDysFDTCKPP
0 12 Y599-p KDLVSCAyQVARGME
0 2 Y607-p QVARGMEyLASQKCI
0 1 K632-ub VTEDNVMkIADFGLA
1 47 Y647-p RDVHNLDyyKKTTNG
1 18 Y648-p DVHNLDyyKKTTNGR
2 3 Y724-p ANCTHDLyMIMRECW
2 0 Y760-p TVTSTDEyLDLSAPF
1 0 Y770-p LSAPFEQySPGGQDt
0 2 T777-p ySPGGQDtPSSSSSG
0 2 S787-p SSSSGDDsVFAHDLL
  FGFR3 iso3  
- gap
S312 YVTVLKVSLESNAsM
S318-p VSLESNAsMSSNtPL
T323-p NAsMSSNtPLVRIAR
S332 LVRIARLSSGEGPTL
S333 VRIARLSSGEGPTLA
K418 VSEMEMMKMIGKHKN
Y440 CTQGGPLYVLVEYAA
Y465 RRPPGLDYSFDTCKP
S466 RPPGLDYSFDTCKPP
Y487 KDLVSCAYQVARGME
Y495 QVARGMEYLASQKCI
K520 VTEDNVMKIADFGLA
Y535 RDVHNLDYYKKTTNG
Y536 DVHNLDYYKKTTNGR
Y612 ANCTHDLYMIMRECW
Y648 TVTSTDEYLDLSAPF
Y658 LSAPFEQYSPGGQDT
T665 YSPGGQDTPSSSSSG
S675 SSSSGDDSVFAHDLL
  mouse

 
S402 PPKKGLGSPTVHKVS
S418-p FPLKRQVsLESNSSM
S424 VsLESNSSMNSNTPL
T429 NSSMNSNTPLVRIAR
S438-p LVRIARLssGEGPVL
S439-p VRIARLssGEGPVLA
K524 VSEMEMMKMIGKHKN
Y546-p CTQGGPLyVLVEYAA
Y571 RRPPGMDYSFDACRL
S572 RPPGMDYSFDACRLP
Y593-p KDLVSCAyQVARGME
Y601 QVARGMEYLASQKCI
K626 VTEDNVMKIADFGLA
Y641-p RDVHNLDyyKKTTNG
Y642-p DVHNLDyyKKTTNGR
Y719 ASCTHDLYMIMRECW
Y755 TVTSTDEYLDLSVPF
Y765 LSVPFEQYSPGGQDT
T772 YSPGGQDTPSSSSSG
S782 SSSSGDDSVFTHDLL
  rat

 
S402 PPKKGLGSPTVHKVS
S418 FPLKRQVSLESNSSM
S424 VSLESNSSMNSNTPL
T429 NSSMNSNTPLVRIAR
S438-p LVRIARLssGEGPVL
S439-p VRIARLssGEGPVLA
K524 VSEMEMMKMIGKHKN
Y546 CTQGGPLYVLVEYAA
Y571 RRPPGMDYSFDACRL
S572 RPPGMDYSFDACRLP
Y593 KDLVSCAYQVARGME
Y601 QVARGMEYLASQKCI
K626 VTEDNVMKIADFGLA
Y641-p RDVHNLDyyKKTTNG
Y642-p DVHNLDyyKKTTNGR
Y718 ANCTHDLYMIMRECW
Y754 TVTSTDEYLDLSVPF
Y764 LSVPFEQYSPGGQDT
T771 YSPGGQDTPSSSSSG
S781 SSSSGDDSVFTHDLL
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