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FGFR3
a receptor tyrosine kinase of the highly-conserved FGFR family that binds fibroblast growth factor (FGF). Mutations are associated with thanatophoric dysplasia (TD), craniosynostosis Adelaide type, many craniosynostotic syndromes and bone malformations. Three splice-variant isoforms have been described. Activating point mutations cause dwarfism, including achondroplasia, hypochrondroplasia and thanatophoric dysplasia, and facial and other morphogenetic disorders, including Crouzon syndrome, craniosynostosis Adelaide type, San Diego skeletal displasia and Muenke syndrome. Translocations t(4;14) involving the IgH region are common in multiple myeloma and frequently involve FGFR3. Activated FGFR3 found in 30% of bladder cancers and several cervical cancers, but not in other tumors. Two mutations found in colorectal cancer. Note: This description may include information from UniProtKB.
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| Protein type: Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Membrane protein, integral; Protein kinase, TK; TK group; FGFR family |
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Cellular Component: internal side of plasma membrane; focal adhesion; perinuclear region of cytoplasm; endoplasmic reticulum; integral to plasma membrane; lysosome; cytoplasmic membrane-bound vesicle; plasma membrane
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Molecular Function: protein binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding
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Biological Process: peptidyl-tyrosine phosphorylation; apoptosis; somatic stem cell maintenance; positive regulation of apoptosis; protein amino acid autophosphorylation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of apoptosis; substantia nigra development; inner ear receptor cell differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; morphogenesis of an epithelium; chondrocyte differentiation; response to axon injury; skeletal development; endochondral ossification; negative regulation of epithelial cell proliferation; negative regulation of developmental growth; fibroblast growth factor receptor signaling pathway; myelination in the central nervous system; MAPKKK cascade; positive regulation of phosphoinositide 3-kinase activity; digestive tract morphogenesis; JAK-STAT cascade; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of protein ubiquitination; negative regulation of smoothened signaling pathway; negative regulation of astrocyte differentiation; negative regulation of mitosis; insulin receptor signaling pathway; lens morphogenesis in camera-type eye; positive regulation of endothelial cell proliferation; positive regulation of cell differentiation; negative regulation of apoptosis
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Reference #:
P22607 (UniProtKB)
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| Alt. Names/Synonyms: ACH; achondroplasia, thanatophoric dwarfism; CD333; CEK2; FGFR-3; FGFR3; Fibroblast growth factor receptor 3; HSFGFR3EX; hydroxyaryl-protein kinase; JTK4; tyrosine kinase JTK4 |
| Gene Symbols: FGFR3 |
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Molecular weight: 87,710 Da
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Basal Isoelectric point: 5.59
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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ESC Pluripotency and Differentiation
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Tyrosine Kinases
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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