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Protein Page:
POLH (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
POLH DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Interacts with REV1. Interacts with monoubiquitinated PCNA, but not unmodified PCNA. Interacts with POLI. Belongs to the DNA polymerase type-Y family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transferase; EC 2.7.7.7; DNA repair, damage
Cellular Component: nucleoplasm
Molecular Function: protein binding; metal ion binding; DNA-directed DNA polymerase activity; damaged DNA binding
Biological Process: regulation of DNA repair; DNA synthesis during DNA repair; postreplication repair; pyrimidine dimer repair; DNA-dependent DNA replication; DNA repair; response to UV-C
Reference #:  Q9Y253 (UniProtKB)
Alt. Names/Synonyms: DNA polymerase eta; FLJ16395; FLJ21978; POLH; polymerase (DNA directed), eta; RAD30; RAD30 homolog A; RAD30A; Xeroderma pigmentosum variant type protein; XP-V; XPV
Gene Symbols: POLH
Molecular weight: 78,413 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Select Structure to View Below

POLH

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S601‑p
cell growth, altered: S587‑p, T617‑p
intracellular localization: S587‑p, T617‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K131-u AVQERLQkLQGQPIS
0 5 S379-p VQGDKRLssLRRCCA
0 6 S380-p QGDKRLssLRRCCAL
0 1 K462-u PVTSSEAkTQGSGPA
1 0 S587-p GVSKLEEsSKATPAE
1 1 S601-p EMDLAHNsQSMHASS
1 0 T617-p SKSVLEVtQKATPNP
0 8 K682-u SAVSHQGkRNPKsPL
0 8 S687-p QGkRNPKsPLACTNK
  mouse

 
K131 AVQERLQKLQGQPIS
S378-p FQGDRRLssLRRCCA
S379-p QGDRRLssLRRCCAL
R461 PIASSETRTQGSGPA
S577 DGAVKPVSSKAVSTE
S591 EMNVAGDSPNVLDSP
T606 AYNSQEVTQRATEDQ
K663 PAVSPQGKRNPKsPS
S668-p QGKRNPKsPSASSSK
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