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Protein Page:
CYP4V2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CYP4V2 Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). May have a role in fatty acid and steroid metabolism in the eye. Defects in CYP4V2 are a cause of Bietti crystalline corneoretinal dystrophy (BCD). BCD is an autosomal recessive retinal dystrophy characterized by multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most cases have similar crystals at the corneoscleral limbus. Clinically, BCD is progressive. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, patients develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.-.-; Membrane protein, integral; EC 1.14.13.-; Oxidoreductase
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding; monooxygenase activity
Biological Process: visual perception; response to stimulus; fatty acid omega-oxidation
Reference #:  Q6ZWL3 (UniProtKB)
Alt. Names/Synonyms: BCD; CP4V2; CYP4AH1; CYP4V2; Cytochrome P450 4V2; cytochrome P450, family 4, subfamily V, polypeptide 2; FLJ18432; MGC43534
Gene Symbols: CYP4V2
Molecular weight: 60,724 Da
Basal Isoelectric point: 7.19  Predict pI for various phosphorylation states
Select Structure to View Below

CYP4V2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K116 EVILTSSKQIDkSSM
0 1 K120-ac TSSKQIDkSSMYkFL
0 1 K120 TSSKQIDKSSMYkFL
0 1 K125-ac IDkSSMYkFLEPWLG
0 1 Q259 WEHKKSLQILHTFTN
0 1 N277 AERANEMNANEDCRG
0 1 K354 SNPEVQKKVDHELDD
0 16 K376 PATVEDLKKLRYLEC
0 1 K376 PATVEDLKKLRYLEC
0 1 R379 VEDLKKLRYLECVIK
0 1 K386 RYLECVIKETLRLFP
0 2 S403 PLFARSVSEDCEVAG
0 1 Y411-p EDCEVAGyRVLKGTE
0 1 R412 DCEVAGyRVLKGTEA
0 1 K415 VAGyRVLKGTEAVII
0 1 K471 PRNCIGQKFAVMEEK
0 1 K471 PRNCIGQKFAVMEEK
0 1 K495 FWIESNQKREELGLE
  mouse

 
K116-ub EVILTSSkQIDkSFL
K120 TSSkQIDKSFLYKFL
K120-ub TSSkQIDkSFLYKFL
K125 IDkSFLYKFLQPWLG
K259-ub RDHKRGLkCLHTFTN
K277-ub AERVKERkAEEDWTG
K354-ub TNPEVQRkVDQELDE
K376-ac PVTLEDLkKLkYLDC
K376-ub PVTLEDLkKLkYLDC
K379-ub LEDLkKLkYLDCVIk
K386-ub kYLDCVIkETLRVFP
S403-p PLFARSLsEDCEVGG
Y411 EDCEVGGYkVTkGTE
K412-ub DCEVGGYkVTkGTEA
K415-ub VGGYkVTkGTEAIII
K471-ac PRNCIGQkFAVMEEK
K471-ub PRNCIGQkFAVMEEK
K495-ub FWVESNQkREELGLA
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