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Protein Page:
SDHB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SDHB Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHB are a cause of susceptibility to pheochromocytoma (PCC). A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. Defects in SDHB are the cause of paragangliomas type 4 (PGL4). A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas are most commonly located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear. Defects in SDHB are a cause of paraganglioma and gastric stromal sarcoma (PGGSS); also called Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance. Defects in SDHB are a cause of Cowden-like syndrome (CWDLS). Cowden-like syndrome is a cancer predisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus. Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1
Cellular Component: mitochondrial respiratory chain complex II; mitochondrion; mitochondrial inner membrane
Molecular Function: 2 iron, 2 sulfur cluster binding; ubiquinone binding; protein binding; succinate dehydrogenase (ubiquinone) activity; electron carrier activity; 4 iron, 4 sulfur cluster binding; metal ion binding; 3 iron, 4 sulfur cluster binding
Biological Process: succinate metabolic process; cellular metabolic process; tricarboxylic acid cycle; aerobic respiration
Reference #:  P21912 (UniProtKB)
Alt. Names/Synonyms: DHSB; FLJ92337; Ip; Iron-sulfur subunit of complex II; PGL4; SDH; SDH1; SDH2; SDHB; SDHIP; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Symbols: SDHB
Molecular weight: 31,630 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Select Structure to View Below

SDHB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K41 ATAPRIKKFAIYRWD
0 1 K51 IYRWDPDKAGDKPHM
0 1 K55 DPDKAGDKPHMQTYE
0 5 Y61 DKPHMQTYEVDLNKC
0 1 K67 TYEVDLNKCGPMVLD
0 1 T119-p ACTRRIDtNLNkVSk
0 1 K123 RIDtNLNKVSkIYPL
0 1 K123-ub RIDtNLNkVSkIYPL
0 1 K126 tNLNkVSKIYPLPHM
0 1 K126-sc tNLNkVSkIYPLPHM
0 1 K151 SNFYAQYKSIEPYLk
0 1 K151 SNFYAQYKSIEPYLk
0 1 K158-sc KSIEPYLkKKDESQE
0 1 Y206 YWWNGDKYLGPAVLM
0 2 Y216-p PAVLMQAyRWMIDsR
0 3 S222-p AyRWMIDsRDDFTEE
0 1 K233 FTEERLAKLQDPFSL
0 3 K233-ub FTEERLAkLQDPFSL
0 1 K267 GKAIAEIKKMMATYK
0 1 K267-ub GKAIAEIkKMMATYK
0 1 K276 MMATYKEKKASV___
  mouse

 
K43-ac AAAPRIKkFAIYRWD
K53-ac IYRWDPDkTGDkPRM
K57-ac DPDkTGDkPRMQTYE
Y63 DkPRMQTYEVDLNkC
K69-ac TYEVDLNkCGPMVLD
T121 ACTRRIDTDLSkVSk
K125-ac RIDTDLSkVSkIYPL
K125 RIDTDLSKVSkIYPL
K128-ac TDLSkVSkIYPLPHM
K128-sc TDLSkVSkIYPLPHM
K153-ac SNFYAQYkSIEPYLk
K153-sc SNFYAQYkSIEPYLk
K160-sc kSIEPYLkKKDESQE
Y208-p YWWNGDKyLGPAVLM
Y218-p PAVLMQAyRWMIDsR
S224-p AyRWMIDsRDDFTEE
K235-ac FTEERLAkLQDPFSV
K235-ub FTEERLAkLQDPFSV
K269-ac GKAIAEIkKMMATYK
K269 GKAIAEIKKMMATYK
K278-ac MMATYKEkRALA___
  rat

 
T43 AAAPRIKTFAIYRWD
K53 IYRWDPDKAGDKPRM
K57 DPDKAGDKPRMQTyK
Y63-p DKPRMQTyKVDLNKC
K69 TyKVDLNKCGPMVLD
T121 ACTRRIDTDLGKVSK
K125 RIDTDLGKVSKIYPL
K125 RIDTDLGKVSKIYPL
K128 TDLGKVSKIYPLPHM
K128 TDLGKVSKIYPLPHM
K153 SNFYAQYKSIEPYLK
K153 SNFYAQYKSIEPYLK
K160 KSIEPYLKKKDESQE
Y208 YWWNGDKYLGPAVLM
Y218 PAVLMQAYRWMIDSR
S224 AYRWMIDSRDEFTEE
K235 FTEERLAKLQDPFSL
K235 FTEERLAKLQDPFSL
K269 GKAIAEIKKMMATYK
K269 GKAIAEIKKMMATYK
K278 MMATYKEKRALA___
  pig

 
K41 ATAPRIKKFAIYRWD
K51 IYRWDPDKTGDKPHM
K55 DPDKTGDKPHMQTYE
Y61 DKPHMQTYEIDLNNC
N67 TYEIDLNNCGPMVLD
T119 ACTRRIDTNLDKVSK
K123 RIDTNLDKVSKIYPL
K123 RIDTNLDKVSKIYPL
K126 TNLDKVSKIYPLPHM
K126 TNLDKVSKIYPLPHM
K151 SNFYAQYKSIEPYLK
K151 SNFYAQYKSIEPYLK
K158 KSIEPYLKKKDESQE
Y206 YWWNGDKYLGPAVLM
Y216 PAVLMQAYRWMIDSR
S222 AYRWMIDSRDDFTEE
K233 FTEERLAKLQDPFSL
K233 FTEERLAKLQDPFSL
K267 GKAIAEIKKMMATYK
K267 GKAIAEIKKMMATYK
K276 MMATYKEKKASA___
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