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Protein Page:
MMAA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MMAA Probable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Defects in MMAA are the cause of methylmalonic aciduria type cblA (MMAA); also known as methylmalonic aciduria type A or vitamin B12-responsive methylmalonicaciduria of cblA complementation type. MMAA is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive. Belongs to the ArgK family. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.-.-; Chaperone
Chromosomal Location of Human Ortholog: 4q31.21
Cellular Component: mitochondrial matrix
Molecular Function: GTP binding; nucleoside-triphosphatase activity
Biological Process: fatty acid beta-oxidation; vitamin metabolic process; cobalamin biosynthetic process; short-chain fatty acid catabolic process; cobalamin metabolic process; cellular lipid metabolic process; water-soluble vitamin metabolic process
Reference #:  Q8IVH4 (UniProtKB)
Alt. Names/Synonyms: cblA; methylmalonic aciduria (cobalamin deficiency) cblA type; methylmalonic aciduria type A; Methylmalonic aciduria type A protein, mitochondrial; MGC120010; MGC120011; MGC120012; MGC120013; MMAA
Gene Symbols: MMAA
Molecular weight: 46,538 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
Select Structure to View Below

MMAA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S110-p EAITLVEstHsRKKE
0 1 T111-p AITLVEstHsRKKEL
0 1 S113-p TLVEstHsRKKELAQ
0 3 K140 QEQSNKGKPLAFRVG
0 1 S149 LAFRVGLSGPPGAGK
0 1 S157 GPPGAGKSTFIEYFG
0 1 T158 PPGAGKSTFIEYFGK
0 2 K165 TFIEYFGKMLTERGH
0 1 S189-p SSCTSGGsLLGDKTR
0 2 Y207 LSRDMNAYIRPSPTR
0 1 S331-p VIRISARsGEGIsEM
0 1 S336-p ARsGEGIsEMWDKMK
0 1 S352-p FQDLMLAsGELTAKR
  mouse

 
S107 EAITLVESTHTRKRE
T108 AITLVESTHTRKREL
T110 TLVESTHTRKRELAQ
K137-ac QELRNQGkPLTFRVG
S146-p LTFRVGLsGPPGAGK
S154-p GPPGAGKstFIECFG
T155-p PPGAGKstFIECFGk
K162-ac tFIECFGkMLTEQGH
S186 SSCTSGGSLLGDKTR
Y204 LSRDMNAYIRPSPTS
S328 VIRISARSGEGITEM
T333 ARSGEGITEMWDTMR
S349 FQHQMLASGELAAKR
  rat

 
S107 EAITLVESTHTRKKE
T108 AITLVESTHTRKKEL
T110 TLVESTHTRKKELAQ
K137-ac RELQNHGkPFTFRVG
S146 FTFRVGLSGPPGAGK
S154 GPPGAGKSTFIECFG
T155 PPGAGKSTFIECFGK
K162 TFIECFGKMLTERGH
S186 SSCTSGGSLLGDKTR
Y204-p LSRDMNAyIRPSPTS
S328 VIRISARSGEGITEM
T333 ARSGEGITEMWDIMR
S349 FQHRMLASGELAAKR
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