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GLRX5 (human)

Overview GLRX5 Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. Defects in GLRX5 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA). A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. Belongs to the glutaredoxin family. Monothiol subfamily. Note: This description may include information from UniProtKB. Protein type: Oxidoreductase Cellular Component: mitochondrion; nucleus Molecular Function: 2 iron, 2 sulfur cluster binding; electron carrier activity; metal ion binding; protein disulfide oxidoreductase activity Biological Process: cell redox homeostasis; hemopoiesis Reference #:  Q86SX6 (UniProtKB) Alt. Names/Synonyms: C14orf87; FLB4739; GLRX5; glutaredoxin 5; glutaredoxin 5 homolog; glutaredoxin-related protein 5; Glutaredoxin-related protein 5, mitochondrial; GRX5; MGC14129; Monothiol glutaredoxin-5; PR01238; PRO1238 Gene Symbols: GLRX5 Molecular weight: 16,628 Da Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states

Select Structure to View Below GLRX5 2WUL - A/D/C/B=35-150 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE 205950 609588  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S41-p	SGAGGGGsAEQLDAL
0	2		S145-p	LKKLGIHsALLDEKK
0	2		S156	DEKKDQDSk______
0	23		K157-a	EKKDQDSk_______

	mouse
Q37	RAASSGGQAEQLDAL
S141	LKKLGIRSALVDEKD
S151-p	VDEKDQDsk______
K152-a	DEKDQDsk_______

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