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Protein Page:
GLRX5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GLRX5 Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. Defects in GLRX5 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA). A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. Belongs to the glutaredoxin family. Monothiol subfamily. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase
Cellular Component: mitochondrion; nucleus
Molecular Function: 2 iron, 2 sulfur cluster binding; electron carrier activity; metal ion binding; protein disulfide oxidoreductase activity
Biological Process: cell redox homeostasis; hemopoiesis
Reference #:  Q86SX6 (UniProtKB)
Alt. Names/Synonyms: C14orf87; FLB4739; GLRX5; glutaredoxin 5; glutaredoxin 5 homolog; glutaredoxin-related protein 5; Glutaredoxin-related protein 5, mitochondrial; GRX5; MGC14129; Monothiol glutaredoxin-5; PR01238; PRO1238
Gene Symbols: GLRX5
Molecular weight: 16,628 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
Select Structure to View Below

GLRX5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S41-p SGAGGGGsAEQLDAL
0 1 K59 DKVVVFLKGTPEQPQ
0 2 S145-p LKKLGIHsALLDEKK
0 2 S156 DEKKDQDSk______
0 23 K157-ac EKKDQDSk_______
  mouse

 
Q37 RAASSGGQAEQLDAL
K55-sc DKVVVFLkGTPEQPQ
S141 LKKLGIRSALVDEKD
S151-p VDEKDQDsk______
K152-ac DEKDQDsk_______
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