Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
EGR1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
EGR1 Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. By growth factors. Belongs to the EGR C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein; C2H2-type zinc finger protein
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: histone acetyltransferase binding; protein binding; DNA binding; sequence-specific DNA binding; metal ion binding; double-stranded DNA binding; transcription factor activity; transcription factor binding
Biological Process: regulation of long-term neuronal synaptic plasticity; transcription from RNA polymerase II promoter; circadian rhythm; response to nutrient levels; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; response to amphetamine; negative regulation of transcription from RNA polymerase II promoter; response to cocaine; BMP signaling pathway; response to ethanol; learning and/or memory; cellular response to insulin stimulus; positive regulation of neuron apoptosis; response to glucose stimulus; oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; response to electrical stimulus; T cell differentiation; regulation of protein sumoylation; negative regulation of apoptosis
Reference #:  P18146 (UniProtKB)
Alt. Names/Synonyms: AT225; early growth response 1; Early growth response protein 1; EGR-1; EGR1; G0S30; KROX-24; KROX24; Nerve growth factor-induced protein A; NGFI-A; TIS8; Transcription factor ETR103; Transcription factor Zif268; ZIF-268; Zinc finger protein 225; Zinc finger protein Krox-24; ZNF225
Gene Symbols: EGR1
Molecular weight: 57,507 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EGR1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
transcription, altered: S104‑p, T148‑p, S196‑p, S301‑p, S378‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S12-p KAEMQLMsPLQISDP
0 7 S26-p PFGSFPHsPTMDNYP
1 0 S104-p YEHLTAEsFPDISLN
0 2 S120-gl EKVLVETsYPSQTTR
1 0 T148-p PAPNSGNtLWPEPLF
1 0 S196-p PLSCAVPsNDSSPIY
1 0 S301-p AFATQSGsQDLKALN
1 0 S378-p RICMRNFsRSDHLTT
  mouse

 
S12 KAEMQLMSPLQISDP
S26 PFGSFPHSPTMDNYP
S101 YEHLTTESFSDIALN
S117-gl EKAMVETsYPSQTTR
T145 PAPNSGNTLWPEPLF
S194 PLSCAVPSNDSSPIY
S299 AFATQSGSQDLKALN
S376 RICMRNFSRSDHLTT
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.