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EGR1 (human)

Overview EGR1 Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. By growth factors. Belongs to the EGR C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor; C2H2-type zinc finger protein Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function: histone acetyltransferase binding; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; BMP signaling pathway; regulation of long-term neuronal synaptic plasticity; learning and/or memory; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; T cell differentiation; regulation of protein sumoylation; response to insulin stimulus Reference #:  P18146 (UniProtKB) Alt. Names/Synonyms: AT225; early growth response 1; Early growth response protein 1; EGR-1; EGR1; G0S30; KROX-24; KROX24; Nerve growth factor-induced protein A; NGFI-A; TIS8; Transcription factor ETR103; Transcription factor Zif268; ZIF-268; Zinc finger protein 225; Zinc finger protein Krox-24; ZNF225 Gene Symbols: EGR1 Molecular weight: 57,507 Da Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below EGR1 1A1F - A=333-421 (mouse) 1A1G - A=333-421 (mouse) 1A1H - A=333-421 (mouse) 1A1I - A=333-421 (mouse) 1A1J - A=333-421 (mouse) 1A1K - A=333-421 (mouse) 1A1L - A=333-421 (mouse) 1AAY - A=333-421 (mouse) 1F2I - G/H/I/J/K/L=334-389 (mouse) 1G2D - C/F=333-421 (mouse) 1G2F - C/F=333-421 (mouse) 1JK1 - A=333-421 (mouse) 1JK2 - A=333-421 (mouse) 1LLM - C/D=364-415 (mouse) 1P47 - A/B=333-419 (mouse) 1ZAA - C=332-418 (mouse)

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	Sites Implicated In
transcription, altered: S104‑p, T148‑p, S196‑p, S301‑p, S378‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S12-p	KAEMQLMsPLQISDP
0	7		S26-p	PFGSFPHsPTMDNYP
1	0		S104-p	YEHLTAEsFPDISLN
0	2		S120-g	EKVLVETsYPSQTTR
1	0		T148-p	PAPNSGNtLWPEPLF
1	0		S196-p	PLSCAVPsNDSSPIY
1	0		S301-p	AFATQSGsQDLKALN
1	0		S378-p	RICMRNFsRSDHLTT

	mouse
S12	KAEMQLMSPLQISDP
S26	PFGSFPHSPTMDNYP
S101	YEHLTTESFSDIALN
S117-g	EKAMVETsYPSQTTR
T145	PAPNSGNTLWPEPLF
S194	PLSCAVPSNDSSPIY
S299	AFATQSGSQDLKALN
S376	RICMRNFSRSDHLTT

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