Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. By growth factors. Belongs to the EGR C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor; C2H2-type zinc finger protein
Molecular Function: histone acetyltransferase binding; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; BMP signaling pathway; regulation of long-term neuronal synaptic plasticity; learning and/or memory; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; T cell differentiation; regulation of protein sumoylation; response to insulin stimulus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.