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Protein Page:
ABCC4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ABCC4 a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter; Transporter, ABC family; Membrane protein, multi-pass
Cellular Component: membrane; integral to membrane; plasma membrane; platelet dense granule membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ATP binding
Biological Process: ATP catabolic process; platelet activation; platelet degranulation; blood coagulation; transmembrane transport
Reference #:  O15439 (UniProtKB)
Alt. Names/Synonyms: ABCC4; ATP-binding cassette sub-family C member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); canalicular multispecific organic anion transporter (ABC superfamily); EST170205; MOAT-B; MOATB; MRP/cMOAT-related ABC transporter; MRP4; Multi-specific organic anion transporter B; Multidrug resistance-associated protein 4; multispecific organic anion transporter B
Gene Symbols: ABCC4
Molecular weight: 149,527 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ABCC4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y45-p RLEEDDMySVLPEDR
0 4 Q54 VLPEDRSQHLGEELQ
0 1 K66-ub ELQGFWDkEVLRAEN
0 2 K77-ub RAENDAQkPSLTRAI
0 1 S182-p YRKALRLsNMAMGKT
0 1 K264-ub LFSSLRSkTATFTDA
0 1 K293-ub IKMYAWEkSFSNLIT
0 1 K304-ub NLITNLRkKEISKIL
0 1 T388-p VSIRRIQtFLLLDEI
0 1 S404-p QRNRQLPsDGKKMVH
0 2 K515-ub IKACALKkDLQLLED
0 1 K540-ub TTLSGGQkARVNLAR
0 1 S601-p LQYLKAAsQILILkD
0 1 K607-ub AsQILILkDGKMVQk
0 1 K614-ub kDGKMVQkGTYTEFL
0 4 K622-ub GTYTEFLkSGIDFGs
0 1 S629-p kSGIDFGsLLkkDNE
0 1 K632-ub IDFGsLLkkDNEESE
0 1 K633-ub DFGsLLkkDNEESEQ
0 3 P641 DNEESEQPPVPGtPt
0 8 P642 NEESEQPPVPGtPtL
0 44 T646-p EQPPVPGtPtLRNRt
0 4 T648-p PPVPGtPtLRNRtFs
0 1 T653-p tPtLRNRtFsESSVW
0 6 S655-p tLRNRtFsESSVWsQ
0 6 S661-p FsESSVWsQQsSRPs
0 2 S664-p SSVWsQQsSRPsLkD
0 2 S665 SVWsQQsSRPsLkDG
0 7 S668-p sQQsSRPsLkDGALE
0 1 K670-ub QsSRPsLkDGALEsQ
0 1 S676-p LkDGALEsQDTENVP
0 1 K695-ub EENRSEGkVGFQAYk
0 1 K702-ub kVGFQAYkNYFRAGA
0 1 K807-ac KMFESILkAPVLFFD
0 1 T913-p SSLQGLWtIRAYkAE
0 1 K918-ub LWtIRAYkAEERCQE
0 1 K1021-ub IEYTDLEkEAPWEYQ
0 1 K1070-ub ALIKSQEkVGIVGRT
0 1 K1165-ub TIEDLPGkMDTELAE
0 1 T1168 DLPGkMDTELAESGS
0 1 S1173 MDTELAESGSNFSVG
0 1 K1253-ub VLDSGRLkEyDEPyV
0 2 Y1255-p DSGRLkEyDEPyVLL
0 5 Y1259-p LkEyDEPyVLLQNkE
0 2 K1265-ub PyVLLQNkESLFYkM
0 1 K1271-ub NkESLFYkMVQQLGk
0 2 K1278-ub kMVQQLGkAEAAALT
0 1 K1289-ub AALTETAkQVYFKRN
  mouse

 
F45 RLEEDDMFSVLPEDR
K54-ub VLPEDRSkHLGEELQ
K66 ELQRYWDKELLRAKK
K77 RAKKDSRKPSLTKAI
S182 YRKALRLSNSAMGKT
K264 LFSSLRSKTAAFTDA
K293 IKMYAWEKSFADLIA
K304 DLIANLRKKEISKIL
N388 VSIRRIKNFLLLDEL
S404 QRKAHVPSDGKAIVH
K515-ub IKACALKkDLQLLED
K540 ATLSGGQKARVNLAR
S601 LQYLKAASHILILKD
K607 ASHILILKDGEMVQK
K614 KDGEMVQKGTYTEFL
K622-ub GTYTEFLkSGVDFGS
S629 kSGVDFGSLLKKENE
K632 VDFGSLLKKENEEAE
K633 DFGSLLKKENEEAEP
S641-p ENEEAEPstAPGtPt
T642-p NEEAEPstAPGtPtL
T646-p EPstAPGtPtLRKRT
T648-p stAPGtPtLRKRTFs
T653 tPtLRKRTFsEASIW
S655-p tLRKRTFsEASIWsQ
S661-p FsEASIWsQQssRPs
S664-p ASIWsQQssRPsLKD
S665-p SIWsQQssRPsLKDG
S668-p sQQssRPsLKDGAPE
K670 QssRPsLKDGAPEGQ
G676 LKDGAPEGQDAENTQ
R695 EESRSEGRIGFKAYK
K702 RIGFKAYKNCFSAGA
K807 RMFESILKAPVLFFD
T913 SSLQGLWTIRAYKAE
K918 LWTIRAYKAEERCQE
K1021 IEYTDLEKEAPWECK
K1070 ALIKSREKVGIVGRT
K1165 AIEDLPGKMDtELAE
T1168-p DLPGKMDtELAEsGS
S1173-p MDtELAEsGSNFSVG
K1253 VLDSGRLKEYDEPYV
Y1255 DSGRLKEYDEPYVLL
Y1259 LKEYDEPYVLLQNPE
P1265 PYVLLQNPESLFYKM
K1271 NPESLFYKMVQQLGk
K1278-ub KMVQQLGkGEAAALT
K1289 AALTETAKQVYFRRN
  rat

 
F45 RLEEDDMFSVLPEDR
K54 VLPEDRSKHLGEELQ
K66 ELQGYWDKEVLRAKK
K77 RAKKDARKPSLTKAI
S182 YRKALRLSNSAMGKT
K264 LFSSLRSKTAAFTDA
K293 IKMYAWEKSFADLIT
K304 DLITNLRKKEISKIL
N388 VSVRRIKNFLLLDEL
S404 ERKAQEPSDGKAIVH
K515 IKACALKKDLQLLED
K540 ATLSGGQKARVNLAR
S601 LQYLKAASHILILKD
K607 ASHILILKDGEMVQK
K614 KDGEMVQKGTYTEFL
K622 GTYTEFLKSGVDFGS
S629 KSGVDFGSLLKKENE
K632 VDFGSLLKKENEEAE
K633 DFGSLLKKENEEAEP
S641-p ENEEAEPsPVPGtPT
P642 NEEAEPsPVPGtPTL
T646-p EPsPVPGtPTLRNRT
T648 sPVPGtPTLRNRTFS
T653 tPTLRNRTFSEASIW
S655 TLRNRTFSEASIWSQ
S661 FSEASIWSQQSSRPs
S664 ASIWSQQSSRPsLKD
S665 SIWSQQSSRPsLKDG
S668-p SQQSSRPsLKDGVPD
K670 QSSRPsLKDGVPDAQ
A676 LKDGVPDAQDAENTQ
R695 EESRSEGRIGFKAYK
K702 RIGFKAYKNYFSAGA
K807 RMFESILKAPVLFFD
T913 SSLQGLWTIRAYKAE
K918 LWTIRAYKAEERCQE
K1021 IEYTDLEKEAPWECR
K1070 ALIKSREKVGIVGRT
K1165 AIEDLPGKMDTELAE
T1168 DLPGKMDTELAESGS
S1173 MDTELAESGSNFSVG
R1253 VLDSGRLREYDEPYV
Y1255 DSGRLREYDEPYVLL
Y1259 LREYDEPYVLLQNPE
P1265 PYVLLQNPESLFYKM
K1271 NPESLFYKMVQQLGK
K1278 KMVQQLGKGEAAALT
K1289 AALTETAKQVYFRRN
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