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Protein Page:
ABCC4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ABCC4 a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, ABC family
Chromosomal Location of Human Ortholog: 13q32
Cellular Component: membrane; basolateral plasma membrane; plasma membrane; integral to membrane; platelet dense granule membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ATP binding
Biological Process: response to drug; platelet activation; platelet degranulation; positive regulation of smooth muscle cell proliferation; response to organic nitrogen; blood coagulation; response to organic cyclic substance; transmembrane transport
Reference #:  O15439 (UniProtKB)
Alt. Names/Synonyms: ABCC4; ATP-binding cassette sub-family C member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); canalicular multispecific organic anion transporter (ABC superfamily); EST170205; MOAT-B; MOATB; MRP/cMOAT-related ABC transporter; MRP4; Multi-specific organic anion transporter B; Multidrug resistance-associated protein 4; multispecific organic anion transporter B
Gene Symbols: ABCC4
Molecular weight: 149,527 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ABCC4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y45-p RLEEDDMySVLPEDR
0 4 Q54 VLPEDRSQHLGEELQ
0 1 K66-ub ELQGFWDkEVLRAEN
0 2 K77-ub RAENDAQkPSLTRAI
0 1 S182-p YRKALRLsNMAMGKT
0 1 K264-ub LFSSLRSkTATFTDA
0 1 K293-ub IKMYAWEkSFSNLIT
0 1 K304-ub NLITNLRkKEISKIL
0 1 T388-p VSIRRIQtFLLLDEI
0 2 S404-p QRNRQLPsDGKKMVH
0 2 K515-ub IKACALKkDLQLLED
0 1 K540-ub TTLSGGQkARVNLAR
0 1 S601-p LQYLKAAsQILILkD
0 1 K607-ub AsQILILkDGKMVQk
0 1 K614-ub kDGKMVQkGTYTEFL
0 4 K622-ub GTYTEFLkSGIDFGs
0 1 S629-p kSGIDFGsLLkkDNE
0 1 K632-ub IDFGsLLkkDNEESE
0 1 K633-ub DFGsLLkkDNEESEQ
0 4 P641 DNEESEQPPVPGtPt
0 10 P642 NEESEQPPVPGtPtL
0 49 T646-p EQPPVPGtPtLRNRt
0 4 T648-p PPVPGtPtLRNRtFs
0 1 T653-p tPtLRNRtFsESSVW
0 6 S655-p tLRNRtFsESSVWsQ
0 1 S658 NRtFsESSVWsQQsS
0 6 S661-p FsESSVWsQQsSRPs
0 3 S664-p SSVWsQQsSRPsLkD
0 3 S665 SVWsQQsSRPsLkDG
0 10 S668-p sQQsSRPsLkDGALE
0 1 K670-ub QsSRPsLkDGALEsQ
0 1 S676-p LkDGALEsQDTENVP
0 1 K695-ub EENRSEGkVGFQAYk
0 1 K702-ub kVGFQAYkNYFRAGA
0 1 K807-ac KMFESILkAPVLFFD
0 1 T913-p SSLQGLWtIRAYkAE
0 1 K918-ub LWtIRAYkAEERCQE
0 1 K1021-ub IEYTDLEkEAPWEYQ
0 1 K1070-ub ALIKSQEkVGIVGRT
0 1 K1165-ub TIEDLPGkMDTELAE
0 1 T1168 DLPGkMDTELAESGS
0 1 S1173 MDTELAESGSNFSVG
0 1 K1253-ub VLDSGRLkEyDEPyV
0 2 Y1255-p DSGRLkEyDEPyVLL
0 5 Y1259-p LkEyDEPyVLLQNkE
0 2 K1265-ub PyVLLQNkESLFYkM
0 1 K1271-ub NkESLFYkMVQQLGk
0 2 K1278-ub kMVQQLGkAEAAALT
0 1 K1289-ub AALTETAkQVYFKRN
  ABCC4 iso2  
Y45 RLEEDDMYSVLPEDR
Q54 VLPEDRSQHLGEELQ
K66 ELQGFWDKEVLRAEN
K77 RAENDAQKPSLTRAI
S182 YRKALRLSNMAMGKT
K264 LFSSLRSKTATFTDA
K293 IKMYAWEKSFSNLIT
K304 NLITNLRKKEISKIL
T388 VSIRRIQTFLLLDEI
S404 QRNRQLPSDGKKMVH
K515 IKACALKKDLQLLED
K540 TTLSGGQKARVNLAR
S601 LQYLKAASQILILKD
K607 ASQILILKDGKMVQK
K614 KDGKMVQKGTYTEFL
K622 GTYTEFLKSGIDFGS
S629 KSGIDFGSLLKKDNE
K632 IDFGSLLKKDNEESE
K633 DFGSLLKKDNEESEQ
P641 DNEESEQPPVPGTPT
P642 NEESEQPPVPGTPTL
T646 EQPPVPGTPTLRNRT
T648 PPVPGTPTLRNRTFS
T653 TPTLRNRTFSESSVW
S655 TLRNRTFSESSVWSQ
S658 NRTFSESSVWSQQSS
S661 FSESSVWSQQSSRPS
S664 SSVWSQQSSRPSLKD
S665 SVWSQQSSRPSLKDG
S668 SQQSSRPSLKDGALE
K670 QSSRPSLKDGALESQ
S676 LKDGALESQDVAYVL
- gap
- gap
K760 KMFESILKAPVLFFD
T866 SSLQGLWTIRAYKAE
K871 LWTIRAYKAEERCQE
K974 IEYTDLEKEAPWEYQ
K1023 ALIKSQEKVGIVGRT
K1118 TIEDLPGKMDTELAE
T1121 DLPGKMDTELAESGS
S1126 MDTELAESGSNFSVG
K1206 VLDSGRLKEYDEPYV
Y1208 DSGRLKEYDEPYVLL
Y1212 LKEYDEPYVLLQNKE
K1218 PYVLLQNKESLFYKM
K1224 NKESLFYKMVQQLGK
K1231 KMVQQLGKAEAAALT
K1242 AALTETAKQVYFKRN
  mouse

 
F45 RLEEDDMFSVLPEDR
K54-ub VLPEDRSkHLGEELQ
K66 ELQRYWDKELLRAKK
K77 RAKKDSRKPSLTKAI
S182 YRKALRLSNSAMGKT
K264 LFSSLRSKTAAFTDA
K293 IKMYAWEKSFADLIA
K304 DLIANLRKKEISKIL
N388 VSIRRIKNFLLLDEL
S404-p QRKAHVPsDGKAIVH
K515-ub IKACALKkDLQLLED
K540 ATLSGGQKARVNLAR
S601 LQYLKAASHILILKD
K607 ASHILILKDGEMVQK
K614 KDGEMVQKGTYTEFL
K622-ub GTYTEFLkSGVDFGS
S629 kSGVDFGSLLKKENE
K632 VDFGSLLKKENEEAE
K633 DFGSLLKKENEEAEP
S641-p ENEEAEPstAPGtPt
T642-p NEEAEPstAPGtPtL
T646-p EPstAPGtPtLRKRT
T648-p stAPGtPtLRKRTFs
T653 tPtLRKRTFsEAsIW
S655-p tLRKRTFsEAsIWsQ
S658-p KRTFsEAsIWsQQss
S661-p FsEAsIWsQQssRPs
S664-p AsIWsQQssRPsLKD
S665-p sIWsQQssRPsLKDG
S668-p sQQssRPsLKDGAPE
K670 QssRPsLKDGAPEGQ
G676 LKDGAPEGQDAENTQ
R695 EESRSEGRIGFKAYK
K702 RIGFKAYKNCFSAGA
K807 RMFESILKAPVLFFD
T913 SSLQGLWTIRAYKAE
K918 LWTIRAYKAEERCQE
K1021 IEYTDLEKEAPWECK
K1070 ALIKSREKVGIVGRT
K1165 AIEDLPGKMDtELAE
T1168-p DLPGKMDtELAEsGS
S1173-p MDtELAEsGSNFSVG
K1253 VLDSGRLKEYDEPYV
Y1255 DSGRLKEYDEPYVLL
Y1259 LKEYDEPYVLLQNPE
P1265 PYVLLQNPESLFYKM
K1271 NPESLFYKMVQQLGk
K1278-ub KMVQQLGkGEAAALT
K1289 AALTETAKQVYFRRN
  rat

 
F45 RLEEDDMFSVLPEDR
K54 VLPEDRSKHLGEELQ
K66 ELQGYWDKEVLRAKK
K77 RAKKDARKPSLTKAI
S182 YRKALRLSNSAMGKT
K264 LFSSLRSKTAAFTDA
K293 IKMYAWEKSFADLIT
K304 DLITNLRKKEISKIL
N388 VSVRRIKNFLLLDEL
S404 ERKAQEPSDGKAIVH
K515 IKACALKKDLQLLED
K540 ATLSGGQKARVNLAR
S601 LQYLKAASHILILKD
K607 ASHILILKDGEMVQK
K614 KDGEMVQKGTYTEFL
K622 GTYTEFLKSGVDFGS
S629 KSGVDFGSLLKKENE
K632 VDFGSLLKKENEEAE
K633 DFGSLLKKENEEAEP
S641-p ENEEAEPsPVPGtPT
P642 NEEAEPsPVPGtPTL
T646-p EPsPVPGtPTLRNRT
T648 sPVPGtPTLRNRTFS
T653 tPTLRNRTFSEASIW
S655 TLRNRTFSEASIWSQ
S658 NRTFSEASIWSQQSS
S661 FSEASIWSQQSSRPs
S664 ASIWSQQSSRPsLKD
S665 SIWSQQSSRPsLKDG
S668-p SQQSSRPsLKDGVPD
K670 QSSRPsLKDGVPDAQ
A676 LKDGVPDAQDAENTQ
R695 EESRSEGRIGFKAYK
K702 RIGFKAYKNYFSAGA
K807 RMFESILKAPVLFFD
T913 SSLQGLWTIRAYKAE
K918 LWTIRAYKAEERCQE
K1021 IEYTDLEKEAPWECR
K1070 ALIKSREKVGIVGRT
K1165 AIEDLPGKMDTELAE
T1168 DLPGKMDTELAESGS
S1173 MDTELAESGSNFSVG
R1253 VLDSGRLREYDEPYV
Y1255 DSGRLREYDEPYVLL
Y1259 LREYDEPYVLLQNPE
P1265 PYVLLQNPESLFYKM
K1271 NPESLFYKMVQQLGK
K1278 KMVQQLGKGEAAALT
K1289 AALTETAKQVYFRRN
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