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ABCC4 (human)

Overview ABCC4 a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Transporter Cellular Component: membrane; integral to membrane; plasma membrane; platelet dense granule membrane Molecular Function: ATPase activity, coupled to transmembrane movement of substances; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ATP binding Biological Process: platelet activation; platelet degranulation; blood coagulation; transmembrane transport Reference #:  O15439 (UniProtKB) Alt. Names/Synonyms: ABCC4; ATP-binding cassette sub-family C member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); canalicular multispecific organic anion transporter (ABC superfamily); EST170205; MOAT-B; MOATB; MRP/cMOAT-related ABC transporter; MRP4; Multi-specific organic anion transporter B; Multidrug resistance-associated protein 4; multispecific organic anion transporter B Gene Symbols: ABCC4 Molecular weight: 149,527 Da Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ABCC4

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y45-p	RLEEDDMySVLPEDR
0	4		Q54	VLPEDRSQHLGEELQ
0	1		K66-u	ELQGFWDkEVLRAEN
0	2		K77-u	RAENDAQkPSLTRAI
0	1		S182-p	YRKALRLsNMAMGKT
0	1		K264-u	LFSSLRSkTATFTDA
0	1		K293-u	IKMYAWEkSFSNLIT
0	1		K304-u	NLITNLRkKEISKIL
0	1		S313-p	EISKILRssCLRGMN
0	1		S314-p	ISKILRssCLRGMNL
0	1		S404-p	QRNRQLPsDGKKMVH
0	2		K515-u	IKACALKkDLQLLED
0	1		K540-u	TTLSGGQkARVNLAR
0	1		S601-p	LQYLKAAsQILILkD
0	1		K607-u	AsQILILkDGKMVQk
0	1		K614-u	kDGKMVQkGTYTEFL
0	4		K622-u	GTYTEFLkSGIDFGS
0	1		K632-u	IDFGSLLkkDNEESE
0	1		K633-u	DFGSLLkkDNEESEQ
0	3		P641	DNEESEQPPVPGtPt
0	8		P642	NEESEQPPVPGtPtL
0	34		T646-p	EQPPVPGtPtLRNRT
0	2		T648-p	PPVPGtPtLRNRTFS
0	5		S655	tLRNRTFSESSVWsQ
0	6		S661-p	FSESSVWsQQSSRPs
0	1		S664	SSVWsQQSSRPsLkD
0	2		S665	SVWsQQSSRPsLkDG
0	4		S668-p	sQQSSRPsLkDGALE
0	1		K670-u	QSSRPsLkDGALESQ
0	1		K695-u	EENRSEGkVGFQAYk
0	1		K702-u	kVGFQAYkNYFRAGA
0	1		K807-a	KMFESILkAPVLFFD
0	1		T913-p	SSLQGLWtIRAYkAE
0	1		K918-u	LWtIRAYkAEERCQE
0	1		K1021-u	IEYTDLEkEAPWEYQ
0	1		K1070-u	ALIKSQEkVGIVGRT
0	1		K1165-u	TIEDLPGkMDTELAE
0	1		T1168	DLPGkMDTELAESGS
0	1		S1173	MDTELAESGSNFSVG
0	1		K1253-u	VLDSGRLkEyDEPyV
0	2		Y1255-p	DSGRLkEyDEPyVLL
0	5		Y1259-p	LkEyDEPyVLLQNkE
0	2		K1265-u	PyVLLQNkESLFYkM
0	1		K1271-u	NkESLFYkMVQQLGk
0	2		K1278-u	kMVQQLGkAEAAALT
0	1		K1289-u	AALTETAkQVYFKRN

	mouse
F45	RLEEDDMFSVLPEDR
K54-u	VLPEDRSkHLGEELQ
K66	ELQRYWDKELLRAKK
K77	RAKKDSRKPSLTKAI
S182	YRKALRLSNSAMGKT
K264	LFSSLRSKTAAFTDA
K293	IKMYAWEKSFADLIA
K304	DLIANLRKKEISKIL
S313	EISKILGSSYLRGMN
S314	ISKILGSSYLRGMNM
S404	QRKAHVPSDGKAIVH
K515-u	IKACALKkDLQLLED
K540	ATLSGGQKARVNLAR
S601	LQYLKAASHILILKD
K607	ASHILILKDGEMVQK
K614	KDGEMVQKGTYTEFL
K622-u	GTYTEFLkSGVDFGS
K632	VDFGSLLKKENEEAE
K633	DFGSLLKKENEEAEP
S641-p	ENEEAEPstAPGtPT
T642-p	NEEAEPstAPGtPTL
T646-p	EPstAPGtPTLRKRT
T648	stAPGtPTLRKRTFs
S655-p	TLRKRTFsEASIWsQ
S661-p	FsEASIWsQQssRPs
S664-p	ASIWsQQssRPsLKD
S665-p	SIWsQQssRPsLKDG
S668-p	sQQssRPsLKDGAPE
K670	QssRPsLKDGAPEGQ
R695	EESRSEGRIGFKAYK
K702	RIGFKAYKNCFSAGA
K807	RMFESILKAPVLFFD
T913	SSLQGLWTIRAYKAE
K918	LWTIRAYKAEERCQE
K1021	IEYTDLEKEAPWECK
K1070	ALIKSREKVGIVGRT
K1165	AIEDLPGKMDtELAE
T1168-p	DLPGKMDtELAEsGS
S1173-p	MDtELAEsGSNFSVG
K1253	VLDSGRLKEYDEPYV
Y1255	DSGRLKEYDEPYVLL
Y1259	LKEYDEPYVLLQNPE
P1265	PYVLLQNPESLFYKM
K1271	NPESLFYKMVQQLGk
K1278-u	KMVQQLGkGEAAALT
K1289	AALTETAKQVYFRRN

	rat
F45	RLEEDDMFSVLPEDR
K54	VLPEDRSKHLGEELQ
K66	ELQGYWDKEVLRAKK
K77	RAKKDARKPSLTKAI
S182	YRKALRLSNSAMGKT
K264	LFSSLRSKTAAFTDA
K293	IKMYAWEKSFADLIT
K304	DLITNLRKKEISKIL
S313	EISKILGSSYLRGMN
S314	ISKILGSSYLRGMNM
S404	ERKAQEPSDGKAIVH
K515	IKACALKKDLQLLED
K540	ATLSGGQKARVNLAR
S601	LQYLKAASHILILKD
K607	ASHILILKDGEMVQK
K614	KDGEMVQKGTYTEFL
K622	GTYTEFLKSGVDFGS
K632	VDFGSLLKKENEEAE
K633	DFGSLLKKENEEAEP
S641-p	ENEEAEPsPVPGtPT
P642	NEEAEPsPVPGtPTL
T646-p	EPsPVPGtPTLRNRT
T648	sPVPGtPTLRNRTFS
S655	TLRNRTFSEASIWSQ
S661	FSEASIWSQQSSRPS
S664	ASIWSQQSSRPSLKD
S665	SIWSQQSSRPSLKDG
S668	SQQSSRPSLKDGVPD
K670	QSSRPSLKDGVPDAQ
R695	EESRSEGRIGFKAYK
K702	RIGFKAYKNYFSAGA
K807	RMFESILKAPVLFFD
T913	SSLQGLWTIRAYKAE
K918	LWTIRAYKAEERCQE
K1021	IEYTDLEKEAPWECR
K1070	ALIKSREKVGIVGRT
K1165	AIEDLPGKMDTELAE
T1168	DLPGKMDTELAESGS
S1173	MDTELAESGSNFSVG
R1253	VLDSGRLREYDEPYV
Y1255	DSGRLREYDEPYVLL
Y1259	LREYDEPYVLLQNPE
P1265	PYVLLQNPESLFYKM
K1271	NPESLFYKMVQQLGK
K1278	KMVQQLGKGEAAALT
K1289	AALTETAKQVYFRRN

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