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Protein Page:
AMACR (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
AMACR Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. Belongs to the CaiB/BaiF CoA-transferase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - primary bile acid biosynthesis; Mitochondrial; Isomerase; EC 5.1.99.4
Cellular Component: peroxisomal matrix; mitochondrion; cytoplasm; peroxisome
Molecular Function: alpha-methylacyl-CoA racemase activity; receptor binding
Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; bile acid metabolic process; cellular lipid metabolic process
Reference #:  Q9UHK6 (UniProtKB)
Alt. Names/Synonyms: 2-methylacyl-CoA racemase; Alpha-methylacyl-CoA racemase; AMACR; CBAS4; RACE; RM
Gene Symbols: AMACR
Molecular weight: 42,387 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AMACR

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S39 VRVDRPGSRYDVSRL
0 32 K58 RSLVLDLKQPRGAAV
0 1 K87 FRRGVMEKLQLGPEI
0 1 R101 ILQRENPRLIYARLS
0 1 R118 GQSGSFCRLAGHDIN
0 1 R118 GQSGSFCRLAGHDIN
0 1 K135 ALSGVLSKIGRSGEN
0 1 - gap
0 3 - gap
  AMACR iso2  
S39 VRVDRPGSRYDVSRL
K58 RSLVLDLKQPRGAAV
K87 FRRGVMEKLQLGPEI
R101 ILQRENPRLIYARLS
R118 GQSGSFCRLAGHDIN
R118 GQSGSFCRLAGHDIN
- gap
- gap
- gap
  mouse

 
S39-p VRVNRLGsTGENFLA
K57-a RSLALDLkRSQGVTV
K86-a FRCGVMEkLQLGPET
K100-u TLLQDNPkLIYARLS
K117-u GQSGIFSkVAGHDIN
K117-a GQSGIFSkVAGHDIN
K134-u ALSGVLSkIGRSGEN
K204-u TQPMGLWkQPRGQNI
K276-a KFADVFAkKTKAEWC
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