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AMACR (human)

Overview AMACR Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. Belongs to the CaiB/BaiF CoA-transferase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Mitochondrial; Isomerase; Lipid Metabolism - primary bile acid biosynthesis; EC 5.1.99.4 Cellular Component: peroxisomal matrix; mitochondrion; cytoplasm; peroxisome Molecular Function: alpha-methylacyl-CoA racemase activity; receptor binding Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; bile acid metabolic process; cellular lipid metabolic process Reference #:  Q9UHK6 (UniProtKB) Alt. Names/Synonyms: 2-methylacyl-CoA racemase; Alpha-methylacyl-CoA racemase; AMACR; CBAS4; RACE; RM Gene Symbols: AMACR Molecular weight: 42,387 Da Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AMACR

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE 214950 604489  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S39	VRVDRPGSRYDVSRL
0	32		K58-a	RSLVLDLkQPRGAAV
0	1		K87	FRRGVMEKLQLGPEI
0	1		R101	ILQRENPRLIYARLS
0	1		R118	GQSGSFCRLAGHDIN
0	1		R118	GQSGSFCRLAGHDIN
0	1		K135	ALSGVLSKIGRSGEN
0	1		E205	TQKLSLWEAPRGQNM
0	3		E277	KFADVFAEKTKAEWC
0	1		-	gap

	AMACR iso2
S39	VRVDRPGSRYDVSRL
K58	RSLVLDLKQPRGAAV
K87	FRRGVMEKLQLGPEI
R101	ILQRENPRLIYARLS
R118	GQSGSFCRLAGHDIN
R118	GQSGSFCRLAGHDIN
-	under review
-	under review
-	gap
T153-p	EIESVGStSRTEHVG

	mouse
S39-p	VRVNRLGsTGENFLA
K57-a	RSLALDLkRSQGVTV
K86-a	FRCGVMEkLQLGPET
K100-u	TLLQDNPkLIYARLS
K117-u	GQSGIFSkVAGHDIN
K117-a	GQSGIFSkVAGHDIN
K134-u	ALSGVLSkIGRSGEN
K204-u	TQPMGLWkQPRGQNI
K276-a	KFADVFAkKTKAEWC
-	gap

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