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Protein Page:
CCNE1 (human)

Overview
CCNE1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Activator protein; Nuclear receptor co-regulator
Cellular Component: nucleoplasm; cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleus
Molecular Function: protein binding; androgen receptor binding; transcription coactivator activity; kinase activity; cyclin-dependent protein kinase regulator activity; protein kinase binding
Biological Process: G1/S-specific transcription in mitotic cell cycle; Wnt receptor signaling pathway; DNA replication initiation; cell division; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; protein amino acid phosphorylation; G1/S transition of mitotic cell cycle
Reference #:  P24864 (UniProtKB)
Alt. Names/Synonyms: CCNE; CCNE1; cyclin E1; cyclin Es; cyclin Et; G1/S-specific cyclin-E1
Gene Symbols: CCNE1
Molecular weight: 47,077 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Select Structure to View Below

CCNE1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: T395‑p
intracellular localization: S399‑p
molecular association, regulation: T77‑p, T395‑p, S399‑p
protein degradation: T77‑p, S387‑p, T395‑p, S399‑p
ubiquitination: T395‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S59-p TARDQCGsQPWDNNA
1 0 S73-p AVCADPCsLIPtPDK
5 1 T77-p DPCsLIPtPDKEDDD
1 0 S90-p DDRVYPNsTCKPRII
1 8 S103-p IIAPSRGsPLPVLSW
0 2 S381-p RAKKAMLsEQNRAsP
2 7 S387-p LsEQNRAsPLPSGLL
12 5 T395-p PLPSGLLtPPQsGKK
4 3 S399-p GLLtPPQsGKKQSSG
4136 : Phospho-Cyclin E (Thr62) Antibody
  mouse

 
S56 TVKSEDSSQPWDDNS
S70 SACVDPCSFIPtPNK
T74-p DPCSFIPtPNKEEDN
T88 NELEYPRTAFQPRKI
S101-p KIRPPRAsPLPVLNW
S379 QAKKAILSEQNRIsP
S385-p LSEQNRIsPPPSVVL
T393-p PPPSVVLtPPPSSKK
S397 VVLtPPPSSKKQSSE
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