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CCNE1 (human)

Overview CCNE1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Nuclear receptor co-regulator; Activator protein Cellular Component: nucleoplasm; centrosome; nucleolus; cyclin-dependent protein kinase holoenzyme complex; nucleus; cytosol Molecular Function: protein binding; androgen receptor binding; transcription coactivator activity; kinase activity; cyclin-dependent protein kinase regulator activity; protein kinase binding Biological Process: response to purine; response to drug; organ regeneration; Wnt receptor signaling pathway; DNA replication initiation; antral ovarian follicle growth; positive regulation of transcription, DNA-dependent; cellular response to nutrient; liver development; protein amino acid phosphorylation; response to estradiol stimulus; G1/S-specific transcription in mitotic cell cycle; response to vitamin E; response to ethanol; cell division; response to cytokine stimulus; response to methylmercury; androgen receptor signaling pathway; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; response to progesterone stimulus; positive regulation of cell differentiation; response to corticosterone stimulus; G1/S transition of mitotic cell cycle Reference #:  P24864 (UniProtKB) Alt. Names/Synonyms: CCNE; CCNE1; cyclin E1; cyclin Es; cyclin Et; G1/S-specific cyclin-E1 Gene Symbols: CCNE1 Molecular weight: 47,077 Da Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint

Select Structure to View Below CCNE1 1W98 - B=96-378 (human)

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	Sites Implicated In
cell cycle regulation: T395‑p intracellular localization: S399‑p molecular association, regulation: T77‑p, T395‑p, S399‑p protein degradation: T77‑p, S387‑p, T395‑p, S399‑p ubiquitination: T395‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S59-p	TARDQCGsQPWDNNA
1	0		S73-p	AVCADPCsLIPtPDK
5	1		T77-p	DPCsLIPtPDKEDDD
1	0		S90-p	DDRVYPNsTCKPRII
1	7		S103-p	IIAPSRGsPLPVLSW
0	2		S381-p	RAKKAMLsEQNRAsP
2	6		S387-p	LsEQNRAsPLPSGLL
12	5		T395-p	PLPSGLLtPPQsGKK
4	3		S399-p	GLLtPPQsGKKQSSG

	mouse
S56	TVKSEDSSQPWDDNS
S70	SACVDPCSFIPtPNK
T74-p	DPCSFIPtPNKEEDN
T88	NELEYPRTAFQPRKI
S101-p	KIRPPRAsPLPVLNW
S379	QAKKAILSEQNRIsP
S385-p	LSEQNRIsPPPSVVL
T393-p	PPPSVVLtPPPSSKK
S397	VVLtPPPSSKKQSSE

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