a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator
Molecular Function: protein binding; androgen receptor binding; transcription coactivator activity; protein complex binding; kinase activity; cyclin-dependent protein kinase regulator activity; protein kinase binding
Biological Process: response to purine; DNA replication initiation; regulation of cell cycle; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; response to estradiol stimulus; response to vitamin E; response to methylmercury; response to corticosterone stimulus; response to drug; organ regeneration; Wnt receptor signaling pathway; antral ovarian follicle growth; cellular response to nutrient; liver development; G1/S-specific transcription in mitotic cell cycle; response to ethanol; cell division; response to cytokine stimulus; androgen receptor signaling pathway; mitotic cell cycle; response to progesterone stimulus; regulation of protein kinase activity; positive regulation of cell differentiation; G1/S transition of mitotic cell cycle
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.