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Protein Page:
CCND1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CCND1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Activator protein
Cellular Component: nucleoplasm; tight junction; membrane; transcriptional repressor complex; cyclin-dependent protein kinase holoenzyme complex; nucleolus; intracellular; cytosol; nucleus
Molecular Function: protein binding; enzyme binding; histone deacetylase binding; protein complex binding; cyclin-dependent protein kinase regulator activity; protein kinase binding; transcription corepressor activity; transcription factor binding; protein kinase activity
Biological Process: G1 DNA damage checkpoint; fat cell differentiation; lactation; re-entry into mitotic cell cycle; negative regulation of Wnt receptor signaling pathway; positive regulation of cyclin-dependent protein kinase activity; positive regulation of mammary gland epithelial cell proliferation; negative regulation of epithelial cell differentiation; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; response to magnesium ion; response to vitamin E; Leydig cell differentiation; response to iron ion; response to corticosterone stimulus; response to X-ray; response to drug; Notch signaling pathway; organ regeneration; transcription, DNA-dependent; unfolded protein response; mammary gland epithelial cell proliferation; liver development; response to organic nitrogen; response to ethanol; response to estrogen stimulus; cell division; mitotic cell cycle; positive regulation of protein amino acid phosphorylation; response to calcium ion; response to DNA damage stimulus; G1/S transition of mitotic cell cycle
Reference #:  P24385 (UniProtKB)
Alt. Names/Synonyms: B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; BCL1; CCND1; CycD1; cyclin D1; D11S287E; G1/S-specific cyclin D1; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31
Gene Symbols: CCND1
Molecular weight: 33,729 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCND1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: T286‑p
cell growth, altered: T286‑p
intracellular localization: T286‑p, T288‑p
molecular association, regulation: T286‑p
protein degradation: T286‑p, T288‑p
ubiquitination: T286‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 K33-ub RVLRAMLkAEETCAP
0 12 K46-ub APSVSYFkCVQkEVL
0 2 K50-ub SYFkCVQkEVLPSMR
1 0 S90-p NYLDRFLsLEPVkkS
0 4 K95-ub FLsLEPVkkSRLQLL
0 1 K96-ub LsLEPVkkSRLQLLG
0 1 S111-p ATCMFVAsKMkETIP
0 1 K114-ub MFVAsKMkETIPLTA
0 1 S131-p LCIYTDNsIRPEELL
0 1 K167-ub FIEHFLSkMPEAEEN
0 5 K175-ub MPEAEENkQIIRKHA
1 0 S197-p ATDVKFIsNPPSMVA
0 1 Y226-p SPNNFLSyYRLTRFL
1 0 S234-p YRLTRFLsRVIkCDP
0 8 K238-ub RFLsRVIkCDPDCLR
1 0 K269-ub AQQNMDPkAAEEEEE
26 4 T286-p EEVDLACtPtDVRDV
5 0 T288-p VDLACtPtDVRDVDI
3300 : Phospho-Cyclin D1 (Thr286) (D29B3) XP(R) Rabbit mAb
8497 : Phospho-Cyclin D1 (Thr286) (D29B3) XP(R) Rabbit mAb (PE Conjugate)
  mouse

 
K33 RVLRAMLKTEETCAP
K46-ub APSVSYFkCVQKEIV
K50 SYFkCVQKEIVPSMR
S90 NYLDRFLSLEPLKKS
K95 FLSLEPLKKSRLQLL
K96 LSLEPLKKSRLQLLG
S111 ATCMFVASKMKETIP
K114 MFVASKMKETIPLTA
S131 LCIYTDNSIRPEELL
K167 FIEHFLSKMPEADEN
K175 MPEADENKQTIRKHA
S197 ATDVKFISNPPSMVA
C226 SPNNFLSCYRTTHFL
S234 YRTTHFLSRVIkCDP
K238-ub HFLSRVIkCDPDCLR
K269 AQQNVDPKATEEEGE
T286-p EEAGLACtPtDVRDV
T288-p AGLACtPtDVRDVDI
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