Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CCNB1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CCNB1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Complexes with cdc2 to form the maturation-promoting factor (MPF). Two alternatively spliced isoforms have been found, a constitutively expressed form and a cell cycle-regulated form that is expressed predominantly during G2/M phase. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Activator protein
Cellular Component: nucleoplasm; spindle pole; centrosome; membrane; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; patched binding; kinase activity; protein kinase binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of histone phosphorylation; regulation of cell cycle; ventricular cardiac muscle cell development; mitotic nuclear envelope disassembly; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of mRNA 3'-end processing; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; negative regulation of protein amino acid phosphorylation; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; tissue regeneration; protein complex assembly; G2/M transition of mitotic cell cycle; positive regulation of cardiac muscle cell proliferation; response to drug; in utero embryonic development; mitotic metaphase plate congression; oocyte maturation; response to DDT; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; gut development; response to mechanical stimulus; spermatogenesis; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; mitotic spindle stabilization; G1/S transition of mitotic cell cycle
Reference #:  P14635 (UniProtKB)
Alt. Names/Synonyms: CCNB; CCNB1; cyclin B1; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1
Gene Symbols: CCNB1
Molecular weight: 48,337 Da
Basal Isoelectric point: 7.09  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCNB1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
intracellular localization: S116‑p, S126‑p, S128‑p, S133‑p, S147‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S9-p ALRVTRNsKINAENK
0 8 K25-ac KINMAGAkRVPTAPA
0 1 K25-ub KINMAGAkRVPTAPA
0 3 S35-p PTAPAATsKPGLRPR
0 1 K51 ALGDIGNKVSEQLQA
0 2 S53 GDIGNKVSEQLQAKM
0 1 S69-p MKKEAKPsATGkVID
0 1 K73-ac AKPsATGkVIDKKLP
2 1 S116-p PVKEEKLsPEPILVD
7 1 S126-p PILVDTAsPsPMETs
5 1 S128-p LVDTAsPsPMETsGC
6 1 S133-p sPsPMETsGCAPAEE
6 1 S147-p EDLCQAFsDVILAVN
0 2 Y177-p YVKDIYAyLRQLEEE
0 2 K190-ub EEQAVRPkYLLGREV
0 1 K257 TAMFIASKYEEMYPP
0 1 K279-ub VTDNTYTkHQIRQME
0 1 K311-ub HFLRRASkIGEVDVE
0 1 T321-p EVDVEQHtLAKYLME
0 1 T362-p ILDNGEWtPTLQHYL
0 1 T395-p VMVNQGLtKHMTVKN
0 1 S413-p TSKHAKIsTLPQLNS
0 1 K428 ALVQDLAKAVAKV__
13495 : Phospho-Cyclin B1 (Ser116) Antibody
4133 : Phospho-Cyclin B1 (Ser133) (9E3) Rabbit mAb
4131 : Phospho-Cyclin B1 (Ser147) Antibody
  mouse

 
T9 ALRVTRNTKINAENK
K25-ac KVSMAGAkRVPVTVT
K25 KVSMAGAKRVPVTVT
S35 PVTVTAASKPGLRPR
K51-ub ALGDIGNkVsEELQA
S53-p GDIGNkVsEELQARV
L69 LKREAKTLGTGKGTV
K73 AKTLGTGKGTVKALP
S113 HVREEKLSPEPILVD
S123 PILVDNPSPSPMETS
S125 LVDNPSPSPMETSGC
S130 SPSPMETSGCAPAEE
S144-p EYLCQAFsDVILAVS
Y174 YVKDIYAYLRQLEEE
K187 EEQSVRPKYLQGREV
K254-ac TAMFIASkYEEMYPP
K276 VTNNTYTKHQIRQME
K308 HFLRRASKVGEVDVE
T318 EVDVEQHTLAKYLME
T359 ILDNGEWTPTLQHYL
T392 VMVNCGLTKHMTVKN
S410 ASKHAKISTLAQLNC
K425-ub TLVQNLSkAVTKA__
4131 : Phospho-Cyclin B1 (Ser147) Antibody
  rat

 
T9 ALRVTRNTKINTENK
K25 KVSMAGAKRVPVAVA
K25 KVSMAGAKRVPVAVA
S34 VPVAVAASkPLLRSR
K50 ALGDIGNKVSEQSRI
S52 GDIGNKVSEQSRIPL
L66 LKKETKKLGSGTVTV
T70 TKKLGSGTVTVKALP
S106 PVMEVKHSPEPILVD
S116 PILVDTPSPSPMETS
S118 LVDTPSPSPMETSGC
S123 SPSPMETSGCAPAEE
S137 EYLCQAFSDVILAVS
Y167 YVKDIYAYLRQLEEE
K180 EEQSVRPKYLLGREV
K247 TAMFIASKYEEMYPP
K269 VTNNTYTKHQIRQME
K301 HFLRRASKIGEVDVE
T311 EVDVEQHTLAKYLME
T352 ILDNGEWTPTLQHYL
T385 VMVNRGLTKHMTIKN
S403 TSKHAKISTLAQLNC
K418 TLVQNLSKAVTKA__
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.