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Protein Page:
CCNB1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CCNB1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Complexes with cdc2 to form the maturation-promoting factor (MPF). Two alternatively spliced isoforms have been found, a constitutively expressed form and a cell cycle-regulated form that is expressed predominantly during G2/M phase. Note: This description may include information from UniProtKB.
Protein type: Activator protein; Cell cycle regulation
Cellular Component: nucleoplasm; spindle pole; centrosome; membrane; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; patched binding; kinase activity; protein kinase binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of histone phosphorylation; regulation of cell cycle; ventricular cardiac muscle cell development; positive regulation of attachment of spindle microtubules to kinetochore; mitotic nuclear envelope disassembly; positive regulation of mRNA 3'-end processing; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; negative regulation of protein amino acid phosphorylation; tissue regeneration; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; protein complex assembly; G2/M transition of mitotic cell cycle; positive regulation of cardiac muscle cell proliferation; response to drug; in utero embryonic development; oocyte maturation; mitotic metaphase plate congression; response to DDT; gut development; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; response to mechanical stimulus; spermatogenesis; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; mitotic spindle stabilization; G1/S transition of mitotic cell cycle
Reference #:  P14635 (UniProtKB)
Alt. Names/Synonyms: CCNB; CCNB1; cyclin B1; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1
Gene Symbols: CCNB1
Molecular weight: 48,337 Da
Basal Isoelectric point: 7.09  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCNB1

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S116‑p, S126‑p, S128‑p, S133‑p, S147‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S9-p ALRVTRNsKINAENK
0 8 K25-a KINMAGAkRVPTAPA
0 2 S35-p PTAPAATsKPGLRPR
0 1 S53 GDIGNKVSEQLQAKM
0 1 S69-p MKKEAKPsATGkVID
0 1 K73-a AKPsATGkVIDKKLP
2 1 S116-p PVKEEKLsPEPILVD
7 1 S126-p PILVDTAsPsPMETs
5 1 S128-p LVDTAsPsPMETsGC
6 1 S133-p sPsPMETsGCAPAEE
6 1 S147-p EDLCQAFsDVILAVN
0 2 Y177-p YVKDIYAyLRQLEEE
0 2 K190-u EEQAVRPkYLLGREV
0 1 K279-u VTDNTYTkHQIRQME
0 1 K311-u HFLRRASkIGEVDVE
0 1 T321-p EVDVEQHtLAKYLME
13495 : Phospho-Cyclin B1 (Ser116) Antibody
4133 : Phospho-Cyclin B1 (Ser133) (9E3) Rabbit mAb
4131 : Phospho-Cyclin B1 (Ser147) Antibody
  mouse

 
T9 ALRVTRNTKINAENK
K25-a KVSMAGAkRVPVTVT
S35 PVTVTAASKPGLRPR
S53-p GDIGNKVsEELQARV
L69 LKREAKTLGTGKGTV
K73 AKTLGTGKGTVKALP
S113 HVREEKLSPEPILVD
S123 PILVDNPSPSPMETS
S125 LVDNPSPSPMETSGC
S130 SPSPMETSGCAPAEE
S144-p EYLCQAFsDVILAVS
Y174 YVKDIYAYLRQLEEE
K187 EEQSVRPKYLQGREV
K276 VTNNTYTKHQIRQME
K308 HFLRRASKVGEVDVE
T318 EVDVEQHTLAKYLME
4131 : Phospho-Cyclin B1 (Ser147) Antibody
  rat

 
T9 ALRVTRNTKINTENK
K25 KVSMAGAKRVPVAVA
S34 VPVAVAASKPLLRSR
S52 GDIGNKVSEQSRIPL
L66 LKKETKKLGSGTVTV
T70 TKKLGSGTVTVKALP
S106 PVMEVKHSPEPILVD
S116 PILVDTPSPSPMETS
S118 LVDTPSPSPMETSGC
S123 SPSPMETSGCAPAEE
S137 EYLCQAFSDVILAVS
Y167 YVKDIYAYLRQLEEE
K180 EEQSVRPKYLLGREV
K269 VTNNTYTKHQIRQME
K301 HFLRRASKIGEVDVE
T311 EVDVEQHTLAKYLME
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