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Protein Page:
CIITA (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CIITA a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; PML body; cell surface
Molecular Function: protein C-terminus binding; protein binding; DNA binding; transcription activator binding; transcription coactivator activity; protein complex binding; ATP binding
Biological Process: transcription, DNA-dependent; negative regulation of collagen biosynthetic process; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; response to antibiotic; positive regulation of MHC class II biosynthetic process; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of MHC class I biosynthetic process; negative regulation of transcription, DNA-dependent; inflammatory response; aging
Reference #:  P33076 (UniProtKB)
Alt. Names/Synonyms: C2TA; CIITA; CIITAIV; class II transactivator; class II, major histocompatibility complex, transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA; NLR family, acid domain containing; NLRA; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
Gene Symbols: CIITA
Molecular weight: 123,514 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CIITA

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S286‑p, S288‑p, S293‑p, S834‑p, S1050‑p
transcription, induced: S280‑p
transcription, inhibited: S373‑p
activity, inhibited: S288‑p, S373‑p
intracellular localization: S286‑p, S288‑p, S293‑p
molecular association, regulation: S280‑p, S288‑p, S373‑p
protein degradation: S280‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K141-a MPAEVGQkSQkRPFP
1 0 K144-a EVGQkSQkRPFPEEL
2 0 S280-p TVHGLPTsPDRPGsT
1 0 S286-p TsPDRPGsTsPFAPs
2 0 S288-p PDRPGsTsPFAPsAT
1 0 S293-p sTsPFAPsATDLPSM
1 0 K315-u RANMTEHkTSPTQCP
1 0 K330-u AAGEVSNkLPkWPEP
1 0 K333-u EVSNkLPkWPEPVEQ
1 0 S373-p VQARLERsSSKSLER
1 0 S834-p QELPGRLsFLGTRLT
1 0 S1050-p AASLLRLsLYNNCIC
  mouse

 
K219 IPVEAGQKPQKRRFP
K222 EAGQKPQKRRFPEEH
S306 SIPSLPESPDRPGST
S312 ESPDRPGSTSPFTPS
S314 PDRPGSTSPFTPSAA
S319 STSPFTPSAADLPSM
- gap
K355 EGPESSIKLPKWPEA
K358 ESSIKLPKWPEAVER
G398 VRARLERGSNKSQER
S859 HQLPGHLSFLGTRLT
S1075 AKSLLRLSLYNNCIC
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