Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CIITA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CIITA a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; PML body; cell surface
Molecular Function: protein C-terminus binding; protein binding; DNA binding; transcription activator binding; transcription coactivator activity; protein complex binding; ATP binding
Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; negative regulation of collagen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; response to antibiotic; positive regulation of MHC class II biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of MHC class I biosynthetic process; immune response; inflammatory response; negative regulation of transcription, DNA-dependent; aging
Reference #:  P33076 (UniProtKB)
Alt. Names/Synonyms: C2TA; CIITA; CIITAIV; class II transactivator; class II, major histocompatibility complex, transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA; NLR family, acid domain containing; NLRA; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
Gene Symbols: CIITA
Molecular weight: 123,514 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CIITA

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Sites Implicated In
transcription, altered: S286‑p, S288‑p, S293‑p, S834‑p, S1050‑p
transcription, induced: S280‑p
transcription, inhibited: S373‑p
activity, inhibited: S288‑p, S373‑p
intracellular localization: S286‑p, S288‑p, S293‑p
molecular association, regulation: S280‑p, S288‑p, S373‑p
protein degradation: S280‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K141-ac MPAEVGQkSQkRPFP
1 0 K144-ac EVGQkSQkRPFPEEL
2 0 S280-p TVHGLPTsPDRPGsT
1 0 S286-p TsPDRPGsTsPFAPs
2 0 S288-p PDRPGsTsPFAPsAT
1 0 S293-p sTsPFAPsATDLPSM
1 0 K315-ub RANMTEHkTSPTQCP
1 0 K330-ub AAGEVSNkLPkWPEP
1 0 K333-ub EVSNkLPkWPEPVEQ
1 0 S373-p VQARLERsSSKSLER
0 1 S427-p GKAGQGKsyWAGAVs
0 1 Y428-p KAGQGKsyWAGAVsR
0 1 S434-p syWAGAVsRAWACGR
0 1 T546-p RGCTLLLtARPRGRL
1 1 S834-p QELPGRLsFLGtRLT
0 1 T838-p GRLsFLGtRLTPPDA
0 1 T947-p TRSSSEDtAGELPAV
0 1 K959-ac PAVRDLKkLEFALGP
1 0 S1050-p AASLLRLsLYNNCIC
0 1 S1073-p RVLPDMVsLRVMDVQ
  mouse

 
K219 IPVEAGQKPQKRRFP
K222 EAGQKPQKRRFPEEH
S306 SIPSLPESPDRPGST
S312 ESPDRPGSTSPFTPS
S314 PDRPGSTSPFTPSAA
S319 STSPFTPSAADLPSM
- gap
K355 EGPESSIKLPKWPEA
K358 ESSIKLPKWPEAVER
G398 VRARLERGSNKSQER
S452 GKAGQGKSHWARTVS
H453 KAGQGKSHWARTVSH
S459 SHWARTVSHTWACGQ
T571 RGCTLLLTARPRGRL
S859 HQLPGHLSFLGTRLT
T863 GHLSFLGTRLTPPDV
A972 LRNPSEDAAKDLPAI
K984 PAIRDLKKLEFALGP
S1075 AKSLLRLSLYNNCIC
S1098 QVLPDMVSLRVMDVQ
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.