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CIITA
a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor; DNA binding protein |
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Cellular Component: nucleoplasm
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Molecular Function: protein C-terminus binding; protein binding; DNA binding; transcription activator binding; transcription coactivator activity; protein complex binding; ATP binding
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Biological Process: response to antibiotic; transcription, DNA-dependent; positive regulation of MHC class II biosynthetic process; negative regulation of collagen biosynthetic process; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; immune response; positive regulation of MHC class I biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
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Reference #:
P33076 (UniProtKB)
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| Alt. Names/Synonyms: C2TA; CIITA; CIITAIV; class II transactivator; class II, major histocompatibility complex, transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA; NLR family, acid domain containing; NLRA; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing |
| Gene Symbols: CIITA |
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Molecular weight: 123,514 Da
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Basal Isoelectric point: 5.3
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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