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Protein Page:
C/EBP-beta (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
C/EBP-beta a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-alpha, -delta and -gamma. Involved in immune and inflammatory responses. Specifically binds to regulatory regions of genes encoding IL-6, other cytokines and several acute-phase proteins. There are two forms of C/EBPbeta, the 38kDa liver activating protein (LAP) and the 20kDa liver inhibitory protein (LIP) which may be products of alternative translation. LAP is a transcriptional activator while LIP may inhibit C/EBPbeta transcriptional activity. Phosphorylated and activated by ERK1/2. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Motility/polarity/chemotaxis; Transcription factor
Cellular Component: nucleoplasm; nuclear matrix; nuclear chromatin; cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor binding; transcription factor activity; glucocorticoid receptor binding
Biological Process: transcription from RNA polymerase II promoter; embryonic placenta development; regulation of interleukin-6 biosynthetic process; mammary gland epithelial cell proliferation; response to lipopolysaccharide; neuron differentiation; positive regulation of osteoblast differentiation; regulation of transcription, DNA-dependent; brown fat cell differentiation; acute-phase response; positive regulation of fat cell differentiation; immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron apoptosis; negative regulation of transcription, DNA-dependent; inflammatory response
Reference #:  P17676 (UniProtKB)
Alt. Names/Synonyms: C/EBP beta; C/EBP-beta; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; CEBPB; CRP2; IL6DBP; interleukin 6-dependent DNA-binding protein; LAP; Liver activator protein; liver-enriched transcriptional activator protein; MGC32080; NF-IL6; Nuclear factor NF-IL6; nuclear factor of interleukin 6; TCF-5; TCF5; Transcription factor 5
Gene Symbols: CEBPB
Molecular weight: 36,106 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Growth And Differentiation Control by MAPKs  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

C/EBP-beta

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y78‑p
cell cycle regulation: Y78‑p
cell differentiation, altered: T235‑p
transcription, altered: T235‑p
transcription, induced: S76‑p, Y78‑p, T235‑p, S325‑p
activity, induced: T235‑p
intracellular localization: S288‑p
molecular association, regulation: T235‑p, T266‑p
protein conformation: S223‑p
protein stabilization: Y78‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 R3-m2 _____MQrLVAWDPA
3 0 K43 LAAAYGGKAAPAAPP
1 0 K43 LAAAYGGKAAPAAPP
7 1 S76-p HERAIDFsPyLEPLG
1 0 Y78-p RAIDFsPyLEPLGAP
5 0 A135 GKNCKKPAEyGyVsL
0 5 Y137-p NCKKPAEyGyVsLGR
1 4 Y139-p KKPAEyGyVsLGRLG
1 2 S141-p PAEyGyVsLGRLGAA
0 1 R144 yGyVsLGRLGAAKGA
1 0 K149 LGRLGAAKGALHPGC
2 0 K174-sm PPPPAELkAEPGFEP
0 1 V216 AYLGYQAVPsGSSGs
0 1 S218-p LGYQAVPsGSSGsLS
0 1 S221 QAVPsGSSGsLSTSS
2 1 S223-p VPsGSSGsLSTSSSS
6 1 T226 GSSGsLSTSSSSsPP
2 0 S227 SSGsLSTSSSSsPPG
1 0 S227 SSGsLSTSSSSsPPG
0 1 S228 SGsLSTSSSSsPPGt
1 0 S228 SGsLSTSSSSsPPGt
0 2 S230 sLSTSSSSsPPGtPS
8 6 S231-p LSTSSSSsPPGtPSP
28 4 T235-p SSSsPPGtPSPADAK
4 0 K264-ac SQVKSKAkktVDkHS
4 1 K265-ac QVKSKAkktVDkHSD
4 0 T266-p VKSKAkktVDkHSDE
0 1 K269-ac KAkktVDkHSDEYKI
3 0 S288-p NNIAVRKsRDKAKMR
1 2 S321 QKKVEQLSRELsTLR
1 0 S325-p EQLSRELsTLRNLFK
3084 : Phospho-C/EBPbeta (Thr235) Antibody
  mouse

 
R3 _____MHRLLAWDAA
K39-ac DCLAYGAkAARAAPR
K39-me DCLAYGAkAARAAPR
S64-p HERAIDFsPYLEPLA
Y66 RAIDFsPYLEPLAPA
A104 AKPSKKPADYGYVSL
Y106 PSKKPADYGYVSLGR
Y108 KKPADYGYVSLGRAG
S110 PADYGYVSLGRAGAk
R113 YGYVSLGRAGAkAAP
K117-ac SLGRAGAkAAPPACF
K133 PPPPAALKAEPGFEP
T169-p AYLGYQAtPSGSsGs
S171 LGYQAtPSGSsGsLS
S174-p QAtPSGSsGsLStss
S176-p tPSGSsGsLStssSs
T179-p GSsGsLStssSssPP
S180 SsGsLStSsSssPPG
S180-gl SsGsLStssSssPPG
S181-p sGsLStssSssPPGt
S181-gl sGsLStssSssPPGt
S183-p sLStssSssPPGtPS
S184-p LStssSssPPGtPSP
T188-p sSssPPGtPSPADAK
K215-ac APAKAKAkktVDKLS
K216-ac PAKAKAkktVDKLSD
T217-p AKAKAkktVDKLSDE
K220 KAkktVDKLSDEYKM
S239 NNIAVRKSRDKAKMR
S272-p QKKVEQLsRELSTLR
S276 EQLsRELSTLRNLFK
3084 : Phospho-C/EBPbeta (Thr235) Antibody
  rat

 
R3 _____MHRLLAWDAA
K39-ac DCLAYGAkAARAAPR
K39 DCLAYGAKAARAAPR
S64-p HERAIDFsPYLEPLA
Y66 RAIDFsPYLEPLAPA
S105-p AKPSKKPsDYGyVsL
Y107 PSKKPsDYGyVsLGr
Y109-p KKPsDYGyVsLGrAG
S111-p PsDYGyVsLGrAGAK
R114-m1 YGyVsLGrAGAKAAP
K118 sLGrAGAKAAPPACF
K134 PPPPAALKAEPGFEP
T170 AYLGYQATPSGSSGs
S172 LGYQATPSGSSGsLS
S175 QATPSGSSGsLSTsS
S177-p TPSGSSGsLSTsSSS
T180 GSSGsLSTsSSSsPP
S181-p SSGsLSTsSSSsPPG
S181 SSGsLSTSSSSsPPG
S182 SGsLSTsSSSsPPGt
S182 SGsLSTsSSSsPPGt
S184 sLSTsSSSsPPGtPS
S185-p LSTsSSSsPPGtPSP
T189-p SSSsPPGtPSPADAK
K216-ac APAKAKAkkAVDKLS
K217-ac PAKAKAkkAVDKLSD
A218 AKAKAkkAVDKLSDE
K221 KAkkAVDKLSDEYKM
S240-p NNIAVRKsRDKAKMR
S273-p QKKVEQLsRELSTLR
S277 EQLsRELSTLRNLFK
3081 : Phospho-C/EBPbeta (Ser105) Antibody (Rat Specific)
3084 : Phospho-C/EBPbeta (Thr235) Antibody
  chicken

 
R3 _____MQRLVAWDAA
K39 DCLAALNKLHPRAAG
K39-me DCLAALNkLHPRAAG
S65 HERAIDFSPYLDPLA
Y67 RAIDFSPYLDPLAAS
P120 GSGGGKKPDYTYISL
Y122 GGGKKPDYTYISLTR
Y124 GKKPDYTYISLTRHG
S126 KPDYTYISLTRHGHP
R129 YTYISLTRHGHPCGS
P133 SLTRHGHPCGSQSHK
K156 PPQIVETKVEPVFET
V201 SYLGYQSVPSGSSGN
S203 LGYQSVPSGSSGNLS
S206 QSVPSGSSGNLSTSS
N208 VPSGSSGNLSTSSSS
T211 GSSGNLSTSSSSSPP
S212 SSGNLSTSSSSSPPG
S212 SSGNLSTSSSSSPPG
S213 SGNLSTSSSSSPPGT
S213 SGNLSTSSSSSPPGT
S215 NLSTSSSSSPPGTPN
S216 LSTSSSSSPPGTPNP
T220 SSSSPPGTPNPSESS
K247 PAGKNKPKKCVDKHS
K248 AGKNKPKKCVDKHSD
C249 GKNKPKKCVDKHSDE
K252 KPKKCVDKHSDEYKL
S271 NNIAVRKSRDKAKMR
S304 QKKVEQLSRELSTLR
S308 EQLSRELSTLRNLFK
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