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PRDM1 (human)

Overview PRDM1 a transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene and can inhibit virus-mediated IFN-¿ production. Recruits chromatin-modifying enzymes including histone deacetylases and methyltransferases. Drives the maturation of B-lymphocytes into Ig secreting cells. Interacts with PRMT5. Expression of Blimp-1 is sufficient to drive terminal differentiation of BCL1 lymphoma cells into antibody secreting plasma cells, increasing the expression of the cell surface marker Syndecan-1. In the B-cell lineage, Blimp-1 is specifically expressed in antibody-secreting cells including activated B and plasma cells. In addition, Blimp-1 has been found during macrophage differentiation and in a subset of T-cells suggesting that it may play a wider role in homeostasis and differentiation. Target genes of Blimp-1 transcriptional repression with potential roles in differentiation include c-Myc, CIITA, Pax5, Spi-B, and Id3.Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transcription, coactivator/corepressor; Methyltransferase, protein lysine, predicted; Transcription regulation; C2H2-type zinc finger protein; DNA binding protein Cellular Component: cytoplasm; nucleus Molecular Function: zinc ion binding; sequence-specific DNA binding; histone deacetylase binding; transcription factor activity Biological Process: negative regulation of lipopolysaccharide-mediated signaling pathway; embryonic placenta development; cell fate commitment; transcription, DNA-dependent; positive regulation of B cell differentiation; negative regulation of B cell proliferation; negative regulation of transcription from RNA polymerase II promoter; maternal placenta development; germ cell development Reference #:  O75626 (UniProtKB) Alt. Names/Synonyms: B-lymphocyte-induced maturation protein 1; Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP-1; BLIMP1; MGC118922; MGC118923; MGC118924; MGC118925; Positive regulatory domain I-binding factor 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PR-domain zinc finger protein 1; PRDI-BF1; PRDI-binding factor 1; PRDI-binding factor-1; PRDM1 Gene Symbols: PRDM1 Molecular weight: 91,771 Da Basal Isoelectric point: 8.76  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PRDM1 3DAL - A/B=2-187 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S227-p	NLTQTQSsLKQPSTE
0	1		T534	HVVQPKATSAAMAAP
0	1		S641-p	QVCHKRFsSTSNLKT
0	6		K678-a	FVHLKLHkRLHTRER

	mouse
N259	NLTQTESNPKQYSSE
T565-p	HVVQPKAtSSVMAAP
S672	QVCHKRFSSTSNLKT
K709	FVHLKLHKRLHTRER

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