Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PRDM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PRDM1 a transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene and can inhibit virus-mediated IFN-┬┐ production. Recruits chromatin-modifying enzymes including histone deacetylases and methyltransferases. Drives the maturation of B-lymphocytes into Ig secreting cells. Interacts with PRMT5. Expression of Blimp-1 is sufficient to drive terminal differentiation of BCL1 lymphoma cells into antibody secreting plasma cells, increasing the expression of the cell surface marker Syndecan-1. In the B-cell lineage, Blimp-1 is specifically expressed in antibody-secreting cells including activated B and plasma cells. In addition, Blimp-1 has been found during macrophage differentiation and in a subset of T-cells suggesting that it may play a wider role in homeostasis and differentiation. Target genes of Blimp-1 transcriptional repression with potential roles in differentiation include c-Myc, CIITA, Pax5, Spi-B, and Id3.Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Methyltransferase, protein lysine, predicted; Transcription regulation; C2H2-type zinc finger protein; DNA binding protein
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cytoplasm; nucleus
Molecular Function: methyltransferase activity; protein binding; sequence-specific DNA binding; histone deacetylase binding; metal ion binding; transcription factor activity
Biological Process: methylation; negative regulation of lipopolysaccharide-mediated signaling pathway; eye photoreceptor cell development; cell fate commitment; transcription, DNA-dependent; positive regulation of B cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of B cell proliferation; germ cell development; maternal placenta development
Reference #:  O75626 (UniProtKB)
Alt. Names/Synonyms: B-lymphocyte-induced maturation protein 1; Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP-1; BLIMP1; MGC118922; MGC118923; MGC118924; MGC118925; Positive regulatory domain I-binding factor 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PR-domain zinc finger protein 1; PRDI-BF1; PRDI-binding factor 1; PRDI-binding factor-1; PRDM1
Gene Symbols: PRDM1
Molecular weight: 91,771 Da
Basal Isoelectric point: 8.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PRDM1

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S21-p LAAPKCNsStVRFQG
0 2 T23-p APKCNsStVRFQGLA
0 1 S227-p NLTQTQSsLKQPSTE
0 2 S272-p DLYRSNIsPLTSEKD
0 1 S351-p DQSLKSSsPHSsPGN
0 1 S355-p KSSsPHSsPGNtVsP
0 1 T359-p PHSsPGNtVsPVGPG
0 1 S361-p SsPGNtVsPVGPGSQ
0 2 S511-p SMKDKACsPTSGSPt
0 1 T518-p sPTSGSPtAGTAATA
0 1 T534 HVVQPKATSAAMAAP
0 1 S641-p QVCHKRFsSTSNLKT
0 6 K678-ac FVHLKLHkRLHTRER
  mouse

 
S54 QAAPKSSSGSVKFQG
S56 APKSSSGSVKFQGLA
N259 NLTQTESNPKQYSSE
S304 DIYRSNISPFTLEKD
S383 EQSLKSSSPHSSPGN
S387 KSSSPHSSPGNTVSP
T391 PHSSPGNTVSPLAPG
S393 SSPGNTVSPLAPGLP
S542 ASMKDESSPPSGSPT
T549 SPPSGSPTAGTAATS
T565-p HVVQPKAtSSVMAAP
S672 QVCHKRFSSTSNLKT
K709 FVHLKLHKRLHTRER
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.