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BAD (human)

Overview BAD a proapoptotic member of the Bcl-2 family. Displaces Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad inducing the phosphorylation of Bad by Akt and p90RSK. 14-3-3 proteins bind phosphorylated Bad, inhibiting its binding to Bcl-2 and Bcl-xL. Phosphorylation by mitochondria-anchored PKA in the BH3 domain can block the dimerization of Bad and Bcl-xL. Note: This description may include information from UniProtKB. Protein type: Apoptosis Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol Molecular Function: protein binding; protein heterodimerization activity; phospholipid binding; caspase activator activity; protein kinase binding; protein phosphatase binding; lipid binding Biological Process: caspase activation; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; apoptosis; positive regulation of apoptosis; cytokine and chemokine mediated signaling pathway; positive regulation of insulin secretion; positive regulation of caspase activity; ADP metabolic process; cellular process regulating host cell cycle in response to virus; glucose homeostasis; ATP metabolic process; glucose catabolic process; positive regulation of T cell differentiation; induction of apoptosis; pore complex biogenesis; positive regulation of B cell differentiation; regulation of mitochondrial membrane permeability; positive regulation of autophagy; positive regulation of epithelial cell proliferation; positive regulation of glucokinase activity Reference #:  Q92934 (UniProtKB) Alt. Names/Synonyms: BAD; BBC2; BBC6; Bcl-2-binding component 6; Bcl-2-like protein 8; BCL-X/BCL-2 binding protein; Bcl-XL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; BCL2-antagonist of cell death protein; BCL2-associated agonist of cell death; BCL2-binding component 6; BCL2-binding protein; Bcl2-L-8; BCL2L8 Gene Symbols: BAD Molecular weight: 18,392 Da Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BAD 1G5J - B=103-127 (human) 2BZW - B=137-163 (mouse)

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	Sites Implicated In
apoptosis, altered: S75‑p, S99‑p, S118‑p apoptosis, inhibited: S75‑p, S99‑p, S118‑p cell adhesion, altered: S75‑p cell growth, altered: S75‑p, S99‑p transcription, altered: S75‑p, S91‑p activation: S75‑p, S99‑p, T137‑p inhibition: S75‑p molecular association, regulation: S74‑p, S75‑p, S99‑p phosphorylation: S74‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		-	gap
0	3		S25-p	AERGLGPsPAGDGPs
0	1		S32-p	sPAGDGPsGsGkHHR
0	3		S34-p	AGDGPsGsGkHHRQA
0	1		K36-a	DGPsGsGkHHRQAPG
1	0		S57	HQQEQPTSSSHHGGA
1	0		S59	QEQPTSSSHHGGAGA
0	23		S71-p	AGAVEIRsRHssyPA
1	69		S74-p	VEIRsRHssyPAGtE
112	169		S75-p	EIRsRHssyPAGtED
0	44		Y76-p	IRsRHssyPAGtEDD
1	21		T80-p	HssyPAGtEDDEGMG
7	24		S91-p	EGMGEEPsPFRGRsR
1	17		S97-p	PsPFRGRsRsAPPNL
110	206		S99-p	PFRGRsRsAPPNLWA
0	1		Y110-p	NLWAAQRyGRELRRM
43	155		S118-p	GRELRRMsDEFVDsF
1	1		S124-p	MsDEFVDsFKKGLPR
6	8		S134-p	KGLPRPKsAGtATQM
2	0		T137-p	PRPKsAGtATQMRQS
0	1		S146-p	TQMRQSSsWTRVFQS
0	4		R161-m1	WWDRNLGrGSSAPSQ
3	0		A165	NLGrGSSAPSQ____

	mouse
S26-p	KSDPGIRsLGSDAGG
S67	TDRGLGPSLTEDQPG
G74	SLTEDQPGPyLAPGL
Y76-p	TEDQPGPyLAPGLLG
-	gap
T94-p	HQQGRAAtNsHHGGA
S96-p	QGRAAtNsHHGGAGA
S108-p	AGAMETRsRHssyPA
S111-p	METRsRHssyPAGtE
S112-p	ETRsRHssyPAGtEE
Y113-p	TRsRHssyPAGtEED
T117-p	HssyPAGtEEDEGME
S128-p	EGMEEELsPFRGRsR
S134-p	LsPFRGRsRsAPPNL
S136-p	PFRGRsRsAPPNLWA
Y147	NLWAAQRYGRELRRM
S155-p	GRELRRMsDEFEGSF
S161	MsDEFEGSFKGLPRP
S170-p	KGLPRPKsAGtATQM
T173-p	PRPKsAGtATQMRQS
G182	TQMRQSAGWTRIIQS
K197	WWDRNLGKGGStPSQ
T201-p	NLGKGGStPSQ____

	rat
S26	KSDPGIRSLGSDAGG
S67	TDRGLGPSLTEDQPG
G74	SLTEDQPGPYLAPGL
Y76	TEDQPGPYLAPGLLG
-	gap
N95	QQPGQAANNSHHGGA
S97	PGQAANNSHHGGAGT
S109	AGTMETRSRHSsYPA
S112	METRSRHSsYPAGtE
S113-p	ETRSRHSsYPAGtEE
Y114	TRSRHSsYPAGtEED
T118-p	HSsYPAGtEEDEGME
S129-p	EGMEEELsPFRGRSR
S135	LsPFRGRSRsAPPNL
S137-p	PFRGRSRsAPPNLWA
Y148	NLWAAQRYGRELRRM
S156-p	GRELRRMsDEFEGSF
S162	MsDEFEGSFKGLPRP
S171	KGLPRPKSAGTATQM
T174	PRPKSAGTATQMRQS
S183	TQMRQSASWTRIIQS
K198	WWDRNLGKGGSTPSQ
T202	NLGKGGSTPSQ____

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