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ATF-4
a transcription factor that is a member of the leucine zipper family. Isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). Involved in cisplatin resistance. Other members of the family include AP-1 transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein; Transcription factor |
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Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; plasma membrane; microtubule organizing center; nucleus
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Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity
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Biological Process: transcription from RNA polymerase II promoter; amino acid metabolic process; unfolded protein response, activation of signaling protein activity; regulation of transcription, DNA-dependent; unfolded protein response; positive regulation of neuron apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; gluconeogenesis
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Reference #:
P18848 (UniProtKB)
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| Alt. Names/Synonyms: Activating transcription factor 4; activating transcription factor 4 (tax-responsive enhancer element B67); ATF4; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB-2; CREB2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; Tax-responsive enhancer element-binding protein 67; TaxREB67; TXREB |
| Gene Symbols: ATF4 |
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Molecular weight: 38,590 Da
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Basal Isoelectric point: 4.83
Predict pI for various phosphorylation states
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CST Pathways:
MAPK/Erk in Growth and Differentiation
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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